Molecular evolution of the hyaluronan synthase 2 gene in mammals: implications for adaptations to the subterranean niche and cancer resistance. [PDF]
Biol Lett, 2015 The naked mole-rat (NMR) Heterocephalus glaber is a unique and fascinating mammal exhibiting many unusual adaptations to a subterranean lifestyle.
Faulkes CG +3 more
europepmc +4 more sources
Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis. [PDF]
Sci Transl Med, 2019 Hepatic stellate cells activated by hyaluronan synthase 2–mediated hyaluronan and Notch1 promote liver fibrosis, identifying a potential target.
Yang YM +19 more
europepmc +6 more sources
Requirement of Hyaluronan Synthase-2 in Craniofacial and Palate Development. [PDF]
J Dent Res, 2019 Cleft palate is a common major birth defect resulting from disruption of palatal shelf growth, elevation, or fusion during fetal palatogenesis. Whereas the molecular mechanism controlling palatal shelf elevation is not well understood, a prevailing hypothesis is that region-specific accumulation of hyaluronan, a predominant extracellular ...
Lan Y, Qin C, Jiang R.
europepmc +4 more sources
Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis. [PDF]
Matrix Biol, 2016 Dysregulated repair of lung injury often results in lung fibrosis characterized by unremitting deposition of matrix components including glycosaminoglycan hyaluronan (HA). HA is mainly produced by hyaluronan synthases (HAS) in mesenchymal cells.
Li Y +9 more
europepmc +3 more sources
Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development
Cells, 2021 The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons.
Emily S. Wilson, Karen Litwa
doaj +1 more source
Human Keratinocytes Respond to Extracellular UTP by Induction of Hyaluronan Synthase 2 Expression and Increased Hyaluronan Synthesis. [PDF]
J Biol Chem, 2017 The release of nucleotides into extracellular space is triggered by insults like wounding and ultraviolet radiation, resulting in stimulatory or inhibitory signals via plasma membrane nucleotide receptors. As similar insults are known to activate hyaluronan synthesis we explored the possibility that extracellular UTP or its breakdown products UDP and ...
Jokela T +7 more
europepmc +4 more sources
Hyaluronan synthase 2 (HAS2) overexpression diminishes the procatabolic activity of chondrocytes by a mechanism independent of extracellular hyaluronan. [PDF]
J Biol Chem, 2019 Osteoarthritis (OA) is a progressive degenerative disease of the joints caused in part by a change in the phenotype of resident chondrocytes within affected joints. This altered phenotype, often termed proinflammatory or procatabolic, features enhanced production of endoproteinases and matrix metallo-proteinases (MMPs) as well as secretion of ...
Ishizuka S +7 more
europepmc +4 more sources
EBioMedicine, 2022 Summary: Background: Since late 2019, SARS-CoV-2 infection has resulted in COVID-19 accompanied by diverse clinical manifestations. However, the underlying mechanism of how SARS-CoV-2 interacts with host and develops multiple symptoms is largely ...
Wei Li +28 more
doaj +1 more source
Salicylate suppresses the oncogenic hyaluronan network in metastatic breast cancer cells
Matrix Biology Plus, 2020 The oncogenic role of hyaluronan in several aspects of tumor biology has been well established. Recent studies by us and others suggest that inhibition of hyaluronan synthesis could represent an emerging therapeutic approach with significant clinical ...
Theodoros T. Karalis +6 more
doaj +1 more source
Reproductive Biology and Endocrinology, 2022 Background Hyaluronan is the main component of the cumulus-oocyte complex (COC) matrix, and it maintains the basic structure of the COC during ovulation.
Hsun-Ming Chang +3 more
doaj +1 more source