Results 21 to 30 of about 19,597 (211)

Selective adhesion inhibition and hyaluronan envelope reduction of dermal tumor cells by cold plasma-activated medium

Cell Adhesion & Migration, 2023
The sensitivity to cold plasma is specific to tumor cells while leaving normal tissue cells unaffected. This is the desired challenge in cancer therapy. Therefore, the focus of this work was a comparative study concerning the plasma sensitivity of dermal
Anna-Christin Golz, Claudia Bergemann, Finja Hildebrandt, Steffen Emmert, Barbara Nebe, Henrike Rebl   +5 more
doaj   +1 more source

Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2 [PDF]

Advanced Materials, 2019
AbstractOsteoarthritis (OA) is a common joint degenerative disease that causes pain, joint damage, and dysfunction. External hyaluronic acid (HA) supplement is a common method for the management of osteoarthritis which requires multi‐injections. It is demonstrated that biodegradable mesoporous silica nanoparticles successfully deliver an enzyme ...
Huimin Li, Huilin Guo, Chang Lei, Li Liu, Liqin Xu, Yaping Feng, Jin Ke, Wei Fang, Hao Song, Chun Xu, Chengzhong Yu, Xing Long   +11 more
openaire   +3 more sources

TGF-β1 upregulates the expression of hyaluronan synthase 2 and hyaluronan synthesis in culture models of equine articular chondrocytes. [PDF]

J Vet Sci, 2018
We investigated the effect of transforming growth factor beta 1 (TGF-β1) on equine hyaluronan synthase 2 (HAS2) gene expression and hyaluronan (HA) synthesis in culture models of articular chondrocytes. Equine chondrocytes were treated with TGF-β1 at different concentrations and times in monolayer cultures.
Ongchai S, Somnoo O, Kongdang P, Peansukmanee S, Tangyuenyong S.   +4 more
europepmc   +3 more sources

Vulnerability to shear stress caused by altered peri-endothelial matrix is a key feature of Moyamoya disease

Scientific Reports, 2021
Moyamoya disease (MMD) is characterized by progressive bilateral stenotic changes in the terminal portion of the internal carotid arteries. Although RNF213 was identified as a susceptibility gene for MMD, the exact pathogenesis remains unknown ...
Muneaki Matsuo, Satomi Nadanaka, Minami Soga, Taku Sugiyama, Shota Serigano, Kenjiro Shimano, Fumio Ichinose, Takuji Nakamura, Toshiyuki Maeda, Kiyohiro Houkin, Takumi Era, Hiroshi Kitagawa   +11 more
doaj   +1 more source

Natural Antisense mRNAs to Hyaluronan Synthase 2 Inhibit Hyaluronan Biosynthesis and Cell Proliferation [PDF]

Journal of Biological Chemistry, 2005
We report the identification of a natural antisense mRNA of hyaluronan synthase 2 that we have chosen to designate as HASNT (for HA synthase 2 antisense) in human and mouse. HASNT is transcribed from the opposite strand of the HAS2 gene locus and is represented by several independent expressed sequence tags in human.
Hsu, Chao, Andrew P, Spicer
openaire   +2 more sources

The role of the multifaceted long non-coding RNAs: A nuclear-cytosolic interplay to regulate hyaluronan metabolism

Matrix Biology Plus, 2021
In the extracellular matrix (ECM), the glycosaminoglycan (GAG) hyaluronan (HA) has different physiological roles favouring hydration, elasticity and cell survival.
Arianna Parnigoni, Ilaria Caon, Paola Moretto, Manuela Viola, Evgenia Karousou, Alberto Passi, Davide Vigetti   +6 more
doaj   +1 more source

Hyaluronan synthase 2 protects skin fibroblasts against apoptosis induced by environmental stress. [PDF]

J Biol Chem, 2014
A balanced turnover of dermal fibroblasts is crucial for structural integrity and normal function of the skin. During recovery from environmental injury (such as UV exposure and physical wounding), apoptosis is an important mechanism regulating fibroblast turnover.
Wang Y, Lauer ME, Anand S, Mack JA, Maytin EV.   +4 more
europepmc   +4 more sources

Overexpression of Hyaluronan Synthase 2 Alters Hyaluronan Distribution and Function in Proximal Tubular Epithelial Cells [PDF]

Journal of the American Society of Nephrology, 2006
The functional consequences of increased renal cortical hyaluronan that is associated with both acute injury and progressive scarring are unclear. The aim of this study was to characterize hyaluronan synthase-2 (HAS2)-driven HA synthesis and determine its effect on renal proximal tubular epithelial cell (PTC) function, because this is known to be the ...
Selbi, Wisam, Day, Anthony J., Rugg, Marilyn S., Fülöp, Csaba, De La Motte, Carol A., Bowen, Timothy, Hascall, Vincent C., Phillips, Aled O.   +7 more
openaire   +2 more sources

HAS2-Ezrin-ER axis plays a role in acquired antiestrogen resistance of ER-positive breast cancer

Frontiers in Pharmacology, 2022
The development of endocrine resistance is a major clinical problem in estrogen receptor-positive (ER+) breast cancer (BrCa) treatment, in which how cancer cells acquire resistance remains obscure.
Xiaodan Sun, Xiaodan Sun, Fen Tang, Qian Guo, Yiwen Liu, Yiqing He, Yan Du, Feng Gao, Feng Gao, Guoliang Zhang, Guoliang Zhang, Cuixia Yang, Cuixia Yang   +12 more
doaj   +1 more source

Hyaluronan and Hyaluronidase, which is better for embryo development? [PDF]

, 2016
Our aim was to examine size-specific effects of Hyaluronan (HA) on preimplantation embryo development. We investigated the effects of Hyalovet (HA, 500–750 kDa; the size produced by HA synthase-3, which is abundant in the oviduct), or HA treated with ...
Ali A. Fouladi-Nashta, Aruffo, Aviles, Bastow, Bergqvist, Block, Bourguignon, Choudhary, Csoka, Dicker, Fenwick, Fouladi-Nashta, Furnus, Furnus, Georgiou, Hahnel, Hess, Kabir A. Raheem, Lane, Laurent, Lesley, Lloyd, Marei, Marei, Mariani, Matwee, Mazdak Salavati, Mehta, Mohey-Elsaeed, Muhammad Khalid, Neira, Oesterreicher, Ohno-Nakahara, Pandey, Pushpakumara, Raheem, Robinson, Rozen, Russell, Ryan, Saliba, Schmidt, Seytanoglu, Stern, Stevenson, Tienthai, Tina Tremaine, Tombolan, Toole, Torner, Ulbrich, Waleed F.A. Marei, Wang, Wathes, Watson, Way, Weigel, Xu, Yevdokimova, Yoon   +59 more
core   +2 more sources