Results 31 to 40 of about 19,597 (211)
Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity [PDF]
Experimental Cell Research, 2005 Osteosarcoma is a common malignant bone tumor associated with childhood and adolescence. The results of numerous studies have suggested that hyaluronan plays an important role in regulating the aggressive behavior of various types of cancer cells. However, no studies have addressed hyaluronan with respect to osteosarcomas.
Yoshihiro, Nishida +3 more
openaire +2 more sources
HAS2 (hyaluronan synthase 2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on HAS2 (hyaluronan synthase 2), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire +2 more sources
Data in Brief, 2018 This data article provides gene expression profiles, determined by using real-time PCR, of fibroblasts and keratinocytes treated with 0.01% and 0.001% extracts of neem plant (Azadirachta indica), local name “Kohomba” in Sri Lanka, harvested in Sri Lanka.
Takao Someya +5 more
doaj +1 more source
Frontiers in Immunology, 2022 HAS2 is a member of the gene family encoding the hyaluronan synthase 2, which can generate high-molecular-weight hyaluronan (HMW-HA). Our previous study identified HAS2 as a candidate gene for increased susceptibility to adult asthma.
Mingma Thsering Sherpa +10 more
doaj +1 more source
Hyaluronan: Biosynthesis and signaling [PDF]
, 2014 Background Hyaluronan is a critical component of extracellular matrix with several different roles. Besides the contribution to the tissue hydration, mechanical properties and correct architecture, hyaluronan plays important biological functions ...
De Luca, G. +5 more
core +1 more source
Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme [PDF]
Journal of Clinical Investigation, 2000 We identified hyaluronan synthase-2 (Has2) as a likely source of hyaluronan (HA) during embryonic development, and we used gene targeting to study its function in vivo. Has2(-/-) embryos lack HA, exhibit severe cardiac and vascular abnormalities, and die during midgestation (E9.5-10).
T D, Camenisch +8 more
openaire +2 more sources
The Malignant Phenotype of Breast Cancer Cells Is Reduced by COX-2 Silencing
Neoplasia: An International Journal for Oncology Research, 2008 The cyclooxygenase (COX) pathway is currently targeted for therapeutic intervention in different cancers. We have previously shown that silencing of COX-2 in the poorly differentiated metastatic breast cell line MDA-MB-231 by RNA interference markedly ...
Ioannis Stasinopoulos +2 more
doaj +1 more source
Synthesis of heparosan oligosaccharides by Pasteurella multocida PmHS2 single-action transferases [PDF]
, 2012 Pasteurella multocida heparosan synthase PmHS2 is a dual action glycosyltransferase that catalyzes the polymerization of heparosan polymers in a non-processive manner.
Boeriu, C.G. +3 more
core +2 more sources
Epidermal Growth Factor Activates Hyaluronan Synthase 2 in Epidermal Keratinocytes and Increases Pericellular and Intracellular Hyaluronan [PDF]
Journal of Biological Chemistry, 2001 Hyaluronan is an abundant and rapidly turned over matrix molecule between the vital cell layers of the epidermis. In this study, epidermal growth factor (EGF) induced a coat of hyaluronan and a 3-5-fold increase in its rate of synthesis in a rat epidermal keratinocyte cell line that has retained its ability for differentiation.
J P, Pienimaki +9 more
openaire +2 more sources
PP2B and ERK1/2 regulate hyaluronan synthesis of HT168 and WM35 human melanoma cell lines [PDF]
, 2015 Hyaluronan (HA) is the major glycosaminoglycan component of the extracellular matrix in either normal or malignant tissues and it may affect proliferation, motility and differentiation of various cell types.
Gergely, Pál +8 more
core +4 more sources