Results 31 to 40 of about 87,553 (215)

PEGPH20, a PEGylated human hyaluronidase, induces radiosensitization by reoxygenation in pancreatic cancer xenografts. A molecular imaging study

Neoplasia: An International Journal for Oncology Research, 2022
Purpose: PEGylated human hyaluronidase (PEGPH20) enzymatically depletes hyaluronan, an important component of the extracellular matrix, increasing the delivery of therapeutic molecules.
Tomohiro Seki, Yu Saida, Shun Kishimoto, Jisook Lee, Yasunori Otowa, Kazutoshi Yamamoto, Gadisetti VR Chandramouli, Nallathamby Devasahayam, James B. Mitchell, Murali C. Krishna, Jeffery R. Brender   +10 more
doaj   +1 more source

Effect of red ginseng NaturalGEL on skin aging

Journal of Ginseng Research, 2020
Background: In aged skin, degradation of collagen fibers, which occupy the majority of the extracellular matrix in the dermis, and changes of aquaporin 3 (AQP3) and skin constituents, such as hyaluronic acid and ceramide, cause wrinkles and decrease skin
Ye Hyang Kim, Hye Rim Park, So Yoon Cha, So Hun Lee, Jung Wung Jo, Jung Nam Go, Kang Hyuk Lee, Su Yeon Lee, Song Seok Shin   +8 more
doaj   +1 more source

Bacillus subtilis Fermentation Augments the Anti-Inflammatory and Skin Moisture Improvement Activities of Tetragonia tetragonoides through the Upregulation of Antioxidant Components

Fermentation, 2023
This study demonstrates that the fermentation of Tetragonia tetragonioides (T. tetragonioides) by Bacillus subtilis (B. subtilis) subsp. spizizenii enhances its antioxidant, anti-inflammatory, and skin-moisturizing activities. Fermented T. tetragonioides
Hyun Kang, Jin-Woo Hwang, Sung-Gyu Lee
doaj   +1 more source

Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma [PDF]

BMC Cancer, 2010
Abstract Background Hyaluronan accumulation correlates with the degree of malignancy in many solid tumor types, including malignant endometrial carcinomas. To elucidate the mechanism of hyaluronan accumulation, we examined the expression levels of the hyaluronan synthases (HAS1, HAS2 and HAS3) and hyaluronidases ...
Kosma Veli-Matti, Hämäläinen Kirsi, Sironen Reijo, Tammi Raija H, Rilla Kirsi, Tammi Markku I, Nykopp Timo K, Heinonen Seppo, Anttila Maarit   +8 more
openaire   +3 more sources

Hydrostatic pressure mimicking diurnal spinal movements maintains anabolic turnover in bovine nucleus pulposus cells in vitro [PDF]

European Cells & Materials, 2021
Treatment strategies for progressive intervertebral-disc degeneration often alleviate pain and other symptoms. With the goal of developing strategies to promote the regeneration of the nucleus pulposus (NP), the present study tried to identify the ...
F Vieira, J Kang, L Ferreira, S Mizuno
doaj   +1 more source

Hyaluronan and Hyaluronidase, which is better for embryo development? [PDF]

, 2016
Our aim was to examine size-specific effects of Hyaluronan (HA) on preimplantation embryo development. We investigated the effects of Hyalovet (HA, 500–750 kDa; the size produced by HA synthase-3, which is abundant in the oviduct), or HA treated with ...
Ali A. Fouladi-Nashta, Aruffo, Aviles, Bastow, Bergqvist, Block, Bourguignon, Choudhary, Csoka, Dicker, Fenwick, Fouladi-Nashta, Furnus, Furnus, Georgiou, Hahnel, Hess, Kabir A. Raheem, Lane, Laurent, Lesley, Lloyd, Marei, Marei, Mariani, Matwee, Mazdak Salavati, Mehta, Mohey-Elsaeed, Muhammad Khalid, Neira, Oesterreicher, Ohno-Nakahara, Pandey, Pushpakumara, Raheem, Robinson, Rozen, Russell, Ryan, Saliba, Schmidt, Seytanoglu, Stern, Stevenson, Tienthai, Tina Tremaine, Tombolan, Toole, Torner, Ulbrich, Waleed F.A. Marei, Wang, Wathes, Watson, Way, Weigel, Xu, Yevdokimova, Yoon   +59 more
core   +2 more sources

Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia.

Experimental Cell Research, 2015
Previous studies have shown that overexpression of enzymatically active GFP-HAS induces the growth of long, slender protrusions that share many features of both filopodia and microvilli. These protrusions are dependent on continuing hyaluronan synthesis, and disrupt upon digestion of hyaluronan by hyaluronidase. However, complete understanding of their
Ville Koistinen, R. Kärnä, A. Koistinen, Antti Arjonen, M. Tammi, K. Rilla   +5 more
semanticscholar   +5 more sources

Growth inhibition associated with disruption of the actin cytoskeleton by Latrunculin A in rhabdomyosarcoma cells.

PLoS ONE, 2020
Functional genomic screening of KRAS-driven mouse sarcomas was previously employed to identify proliferation-relevant genes. Genes identified included Ubiquitin-conjugating enzyme E2 (Ube2c), Centromere Protein E (Cenpe), Hyaluronan Synthase 2 (Has2 ...
Julia Würtemberger, Daria Tchessalova, Carla Regina, Christoph Bauer, Michaela Schneider, Amy J Wagers, Simone Hettmer   +6 more
doaj   +2 more sources

Prognostic value of midkine, syndecan-1, hyaluronan synthase-2, sestrin-1, laminin subunit alpha-4 and fibulin-3 for malignant pleural mesothelioma

Archives of Medical Science, 2021
Introduction The prognosis of malignant pleural mesothelioma (MPM) is poor, with a limited survival time. In this study, we aimed to examine expression levels of genes selected from relevant literature and to utilize in silico methods to determine genes ...
Hakan Akgun, Selma Metintas, Guntulu Ak, Secil Demirkol Canlı, Murat Isbilen, Ali O. Gure, Muzaffer Metintas   +6 more
doaj   +1 more source

Fibroblast and keratinocyte gene expression following exposure to extracts of neem plant (Azadirachta indica)

Data in Brief, 2018
This data article provides gene expression profiles, determined by using real-time PCR, of fibroblasts and keratinocytes treated with 0.01% and 0.001% extracts of neem plant (Azadirachta indica), local name “Kohomba” in Sri Lanka, harvested in Sri Lanka.
Takao Someya, Katsura Sano, Kotaro Hara, Yoshimasa Sagane, Toshihiro Watanabe, R.G.S. Wijesekara   +5 more
doaj   +1 more source