Results 41 to 50 of about 14,665,680 (294)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Psychological Ownership and Resistance to Change in Hybrid Work Environments: An Internalization-Based Explanation

Administrative Sciences
Hybrid work has changed the behavioural foundations of organizational change. Employees are no longer continuously embedded in a common physical workplace where informal communication, shared routines, visible leadership and spontaneous peer sensemaking ...
Sura Sudarshan Sagar, Vidhu Gaur, Ajay K. Jain   +2 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Balancing autonomy and accountability: rethinking performance management in hybrid work

Frontiers in Organizational Psychology
PurposeThis study explores how managers and professional employees in the South African banking sector perceive the balance between autonomy and accountability in hybrid and remote work environments.
Calvin Mabaso
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Navigating Flexibility Through Stability: Emerging Practices in Hybrid Work Coordination [PDF]

Hybrid work arrangements have become widespread in today’s work environments, promising employees flexibility in choosing when and where to work. However, this flexibility introduces new coordination challenges as workgroups must navigate collaborative ...
Williams, Susan P., Gerbl, Jennifer
core   +1 more source

A Vision of Collaborative Verification-Driven Engineering of Hybrid Systems [PDF]

, 2013
Hybrid systems with both discrete and continuous dynamics are an important model for real-world physical systems. The key challenge is how to ensure their correct functioning w.r.t. safety requirements.
Stefan Mitsch, Grant Olney Passmore (5415671), Mitsch, Stefan, Platzer, André, Grant Olney Passmore, Andre Platzer (5363771), Passmore, Grant Olney, Stefan Mitsch (5415674), André Platzer   +8 more
core   +1 more source

The Role of Work Motivation as A Mediating Influence of Work Environment and Islamic Work Discipline on Lecturer Performance [PDF]

, 2023
This study aims to determine the role of work motivation as a mediating influence of work environment and Islamic work discipline on lecturer performance in the era of disruption. The study location is PTMA in the Jakarta and Banten areas.
Lutfi, Mohamad, Bariyah, Oneng Nurul, Koesmawan, Koesmawan, Priharta, Andry, Masyitoh, Masyitoh   +4 more
core   +1 more source

Hybrid work in contemporary organizations. A review of selected models for managing distributed teams and practical recommendations for implementation

Journal of Modern Science
Objectives The aim of this article is to provide an in-depth analysis of selected models of managing distributed teams and to formulate practical recommendations, that may support organizations in the effective adoption of hybrid work.
Małgorzata Sidor-Rządkowska, Magdalena Poroszewska   +1 more
doaj   +1 more source