Results 51 to 60 of about 569,346 (259)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

De la co-localisation à la co‑présence : penser le travail dans les organisations hybrides

Activités
Following the successive lockdowns of 2020-2021, new “hybrid” work arrangements have become extremely widespread in work environments. In practical terms, these new arrangements involve alternating between the office, the home or even a third location ...
Juliette Stéphan, Maria Ianeva, Emmanuel Poussard, Corinne Gaudart, Marc-Éric Bobillier Chaumon   +4 more
doaj   +1 more source

Healthy Work Environment Ecosystems for Teleworking and Hybrid Working

Procedia Computer Science
The COVID-19 pandemic has brought global physical, psychological, social and occupational health challenges. Telework and hybrid work have been a necessary response that has sustained and transformed companies and work at a global level. The main objective of this paper is to understand and characterize how ecosystems of healthy work environments in ...
Tânia Gaspar, Saúl Jesus, Ana Rita Farias, Margarida Gaspar de Matos   +3 more
openaire   +2 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

True nature of hybrid work

Frontiers in Organizational Psychology
IntroductionThis article reviews the discussion concerning hybrid work (HW) during and after the pandemic. We argue that understanding hybrid work as simply dividing working time between an office and another location limits the potential of organizing ...
Matti Vartiainen, Outi Vanharanta
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Making hybrid work work

, 2022
Während das Management virtueller- und klassischer Face-to-Face-Teams stark erforscht ist, gibt es nur wenig Literatur über hybride Teams. Da das Phänomen der hybriden Arbeit erst seit kurzem bekannt ist, werden in dieser Masterarbeit die häufigsten Probleme der hybriden Teamarbeit, die sich aus der massiven Verlagerung hin zu mehr Virtualität in Teams
openaire   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Global trends in work location, before, during, and after COVID-19: office, home, hybrid, and nomad

Urban, Planning and Transport Research
The COVID-19 pandemic led to a sudden shift to digital remote work for most office workers worldwide. This article aims to survey and interpret global data on the shares of four workplace location options that have been adopted since the pandemic ...
Aharon Kellerman
doaj   +1 more source