Results 51 to 60 of about 14,665,680 (294)
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
The hybrid nature of the e-HRM professional: an identity perspective [PDF]
, 2014 This paper provides insights into an under researched area of identity and identity work, that of the e-HRM Professional, drawing on scholarly work to date concerning career identity and hybrid identity.
Williams, H
core
The Influence of Proactive Personality on Innovative Work Behaviour in Hybrid Work Environment
Organizacijų Vadyba: Sisteminiai TyrimaiThere is a strategic need for organisations to design hybrid work environments in a way that promotes innovative behaviours in an increasingly prevalent hybrid work environment.
Škudienė Vida +2 more
doaj +1 more source
Transformative Response in Office Workplace: A Systematic Review of Post-Pandemic Changes
BuildingsThe COVID-19 pandemic has significantly redefined the workplace dynamics, necessitating a pivotal shift from traditional on-site work to remote work and hybrid models, leading to further transformations in office design and operational strategies ...
Huiying (Cynthia) Hou +1 more
doaj +1 more source
Pair Programming Practiced in Hybrid Work
2023 ACM/IEEE International Symposium on Empirical Software Engineering and Measurement (ESEM), 2023 Pair programming (PP) has been a widespread practice for decades and is known for facilitating knowledge exchange and improving the quality of software. Many agilists advocated the importance of collocation, face-to-face interaction, and physical artifacts incorporated in the shared workspace when pairing.
Anastasiia Tkalich +4 more
openaire +3 more sources
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Remote work and hybrid work organizations
, 2022 Remote work, especially working from home, has become the most common form of work in the third decade of the 21st century. What started at the beginning of the millennium as an experimental practice in some companies (mainly in the IT industry) has become widespread and unintentional in 2020 and 2021, due to Covid 19 pandemic.
openaire +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source