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Functional Parameters of Hybridoma Cells: Methods of Evaluation and Biotechnological Relevance
AntibodiesHybridoma technology remains one of the most reliable and widely used platforms for generating highly specific monoclonal antibodies for use in diagnostics, fundamental research, and clinical practice. Moreover, the combination of unlimited proliferative
Tatiana Bezukladnikova +3 more
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Hybridoma-Derived Idiotype Vaccine for Lymphoma: Approval Must Wait
Pharmaceuticals, 2010 Hybridoma-derived idiotype vaccines have been used for the experimental treatment of human lymphoma over the last twenty years, providing evidence of biological efficacy, clinical efficacy and clinical benefit.
Maurizio Bendandi
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A study of antibody secretion from hybridoma cells [PDF]
, 1988 The secretion of monoclonal antibody in both batch and continuous cultures was studied. It was found that when hybridoma cells were continuously cultivated in a simple lab scale fermenter, they secreted less antibody than cells grown in stationary ...
Holland, P.N.
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Optimization of serum-free fermentation processes for antibody production [PDF]
, 1991 Büntemeyer H, Lütkemeyer D, Lehmann J. Optimization of serum-free fermentation processes for antibody production. Cytotechnology. 1991;5(1):57-67.Serum free fermentation procedures of cell cultures have got a wide application in production of ...
Lehmann, Jürgen +2 more
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mBio, 2011 Among the hemiascomycetes, only Candida albicans must switch from the white phenotype to the opaque phenotype to mate. In the recent evolution of this transition, mating-incompetent white cells acquired a unique response to mating pheromone, resulting in
Song Yi +8 more
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Optimal medium use for continuous high density perfusion processes [PDF]
, 1992 Büntemeyer H, Wallerius C, Lehmann J. Optimal medium use for continuous high density perfusion processes. Cytotechnology. 1992;9(1-3):59-67.For maintenance of high cell density in continuous perfusion processes not only feeding with substrates but also ...
Lehmann, Jürgen +2 more
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Design of a bubble-swarm bioreactor for animal cell culture [PDF]
, 1994 Gudermann F, Lütkemeyer D, Lehmann J. Design of a bubble-swarm bioreactor for animal cell culture. Cytotechnology. 1994;15(1-3):301-309.A stationary bubble-swarm has been used to aerate a mammalian cell culture bioreactor with an extremely low gas flow ...
Lehmann, Jürgen +2 more
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Novelty in Biomedicine, 2017 Background: Monomethyl auristatin E (MMAE) is a synthetic analog of dolastatin 10, a compound originally isolated from the marine mollusk. MMAE, as a highly potent microtubule inhibitor, exerts its potent cytotoxic effect by inhibiting microtubule ...
Meghdad Abdollahpour-Alitappeh +9 more
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Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]
, 1991 We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Schwirzke, Marina +4 more
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Novelty in Biomedicine, 2017 Background: Breast cancer is a heterogeneous disease characterized by differential responses to targeted and chemotherapeutic agents. Antibody-drug conjugates are one of the promising strategies for the treatment of breast cancer. Monomethyl auristatin E
Meghdad Abdollahpour-alitappeh +9 more
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