Results 101 to 110 of about 59,454 (330)
Epilepsia, EarlyView.Abstract Objective KCNB1 encodes an α‐subunit of the delayed‐rectifier voltage‐dependent potassium channel Kv2.1. De novo pathogenic variants of KCNB1 have been linked to developmental and epileptic encephalopathies (DEEs), diagnosed in early childhood and sharing limited treatment options.
Lauralee Robichon +7 more
wiley +1 more source
Monoclonal Antibodies which Discriminate Between Native and Oxidized Low Density Lipoproteins
Revista Cubana de Investigaciones Biomédicas, 2020 Introduction: Atherosclerosis is a chronic inflammatory disorder and oxidation of low density lipoproteins (LDL) is thought to play a central role in atherogenesis.
Kenia María Rodríguez Oropesa +2 more
doaj
Critical factors for flow cytometry analysis of the brain
The FEBS Journal, EarlyView.This study explored methods to isolate brain cells for flow cytometry, revealing that protease selection and developmental stage significantly affect cell viability and yield. Autofluorescence varies across brain regions, and neuron markers differ in identifying neuron types.
Mizuki Sadakata +6 more
wiley +1 more source
Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells. [PDF]
, 1989 We report here a mAb, 14-2, reactive with TCRs that include V beta 14. The frequency of V beta 14+ T cells varies with CD4 and CD8 subset and is controlled by the H-2 genes.
Liao, N, Maltzman, J, RAULET, David H.
core
Experimental Physiology, EarlyView.Abstract This study investigated whether performing a translatable murine model of concurrent training after tumour induction affects adaptations in juvenile male and female tumour‐bearing mice. Male and female Balb/c mice were injected bilaterally with colon‐26 adenocarcinoma (C26) cells or PBS at 8 weeks of age.
Stavroula Tsitkanou +10 more
wiley +1 more source
Variable major proteins of Borrelia hermsii. Epitope mapping and partial sequence analysis of CNBr peptides. [PDF]
, 1985 The variable major proteins (VMP) of serotypes 7 and 21 of the relapsing fever agent Borrelia hermsii were isolated by detergent extraction and high performance liquid chromatography.
Barbour, AG +3 more
core
Differential binding patterns of anti-sulfatide antibodies to glial membranes [PDF]
, 2018 Sulfatide is a major glycosphingolipid in myelin and a target for autoantibodies in autoimmune neuropathies. However neuropathy disease models have not been widely established, in part because currently available monoclonal antibodies to sulfatide may ...
Barrie, Jennifer A. +8 more
core +1 more source
The hybridoma-an immunochemical laser.
Clinical Chemistry, 1981 Abstract The advent of hybridoma technology has provided the immunotechnologist a finely tunable instrument that should permit a marked advance in the immunologic sciences. The ability to choose the precise antibody required and the virtually unlimited availability of easily purified antibodies have already resulted in the simultaneous ...
R Bartholomew +5 more
openaire +3 more sources
Presynaptic quantal size enhancement counteracts post‐tetanic release depression
The Journal of Physiology, EarlyView.Abstract figure legend Sustained high‐frequency stimulation decreases the number of synaptic vesicles that fuse per action potential at the Drosophila neuromuscular junction. However, the postsynaptic response remains largely unchanged. An increased postsynaptic response to individual vesicles, likely driven by an increase in vesicle size resulting ...
Anu G. Nair +5 more
wiley +1 more source
Aptamer-based therapeutics and their potential in radiopharmaceutical design [PDF]
, 2007 Aptamers, short, single stranded oligonucleotide entities, have been developed in the past 15 years against a plethora of targets and for a variety of applications.
Ferreira, Catia S. M. +1 more
core +3 more sources