Results 111 to 120 of about 59,454 (330)

A novel method of preparing rat-monoclonal antibody-producing hybridomas by using rat medial iliac lymph node cells.

Cell Structure and Function, 1995
A novel method of preparing hybridomas producing rat monoclonal antibodies was established. The enlarged medial iliac lymph nodes from rats injected via hind footpads with an emulsion of antigen and Freund's adjuvant were used for cell fusion.
Y. Kishiro, M. Kagawa, Ichiro Naito, Y. Sado   +3 more
semanticscholar   +1 more source

Acute introduction of monomeric or multimeric α‐synuclein induces distinct impacts on synaptic vesicle trafficking at lamprey giant synapses

The Journal of Physiology, EarlyView.
Abstract figure legend Monomeric and multimeric α‐synuclein were purified from HEK cells and delivered to lamprey reticulospinal (RS) synapses via axonal microinjection, followed by stimulation (20 Hz, 5 min). Ultrastructural analysis showed that both α‐synuclein species impaired intracellular vesicle trafficking, leading to synaptic vesicle loss and ...
Cristina Román‐Vendrell, Jaqulin N. Wallace, Aurelia Hays Watson, Meral Celikag, Tim Bartels, Jennifer R. Morgan   +5 more
wiley   +1 more source

Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response. [PDF]

, 1992
Although much has been learned about the molecular basis of immunoglobulin M (IgM) rheumatoid factors (RFs) in healthy individuals and in patients with mixed cryoglobulinemia and rheumatoid arthritis, little is known about the genetic origins of the ...
Carson, DA, Chen, PP, Deftos, M, Huang, DF, Kozin, F, Lu, EW, Olee, T, Soto-Gil, RW   +7 more
core  

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules [PDF]

, 1992
Recent studies have demonstrated that the CD3-ζ subunit of the T cell antigen receptor (TCR) complex is involved in signal transduction. However, the function of the remaining invariant subunits, CD3-γ, -δ, and , is still poorly understood.
Alarcon, Anderson, Baniyash, Bauer, Benhamou, Berkhout, Bernot, Bill, Blank, Blumberg, Bonifacino, Bonifacino, Cantrell, Chomczinski, Clayton, Clevers, Clevers, Cosson, De la Herra, Downward, Engel, Finkel, Frank, Gascoigne, Gillis, Goding, Gold, Green, Gunning, Gunter, Hartman, Haser, Herman, Hermanson, Hyman, Irving, Jacobson, Jin, June, Kappler, Kashiwamura, Klausner, Koning, Krissansen, Küster, Labit, Lanier, Leo, Letourneur, Letourneur, Malissen, Manolios, Mercép, Mustelin, Nakayama, O'Shea, Orloff, Orloff, Ortega, Park, Pullen, Ra, Reth, Reth, Romeo, Saito, Sakaguchi, Samelson, Samelson, Samelson, Samelson, Sharp, Siegel, Sussman, Van den Elsen, Vivier, Vivier, Weiss, Weissman, White, Zamoyska   +80 more
core   +2 more sources

V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice.

Journal of Immunology, 1993
Anti-Sm autoantibodies are unique to SLE, but are present in only 25% of patients with this disease. This response also occurs at a similar frequency in mice of the autoimmune MRL strains.
D. Bloom, J. Davignon, M. Retter, M. Shlomchik, David S. Pisetsky, Philip L. Cohen, Robert A. Eisenberg, Stephen H. Clarke   +7 more
semanticscholar   +1 more source

Volitional exercise elicits physiological and molecular improvements in the severe D2.mdx mouse model of Duchenne muscular dystrophy

The Journal of Physiology, EarlyView.
Abstract figure legend This study investigated the effects of volitional exercise on muscle health in the more severe D2.mdx model of Duchenne muscular dystrophy (DMD). We showed that 8–10 weeks of a relatively high volume of voluntary wheel running (VWR) in D2.mdx animals augmented select muscle mass and normalized ex vivo muscle force compared to ...
Stephanie R. Mattina, Sean Y. Ng, Andrew I. Mikhail, Derek W. Stouth, Cora E. Jornacion, Irena A. Rebalka, Thomas J. Hawke, Vladimir Ljubicic   +7 more
wiley   +1 more source

Development and characterization of murine monoclonal antibody specific for the P1.4 PorA proteins from strain B:4:P1.(7b).4. of Neisseria meningitidis

VacciMonitor, 2011
Neisseria meningitidis isolates are conventionally classified by serosubtyping that characterizes the reactivities of the PorA outer membrane protein variable-region epitopes with monoclonal antibodies.
María Elena Pérez, Ramón Barberá, Francisco Domínguez , Oscar Otero, Mercedes Gutiérrez, Gustavo Falero, Grethel Reyes, Franklin Sotolongo, Gustavo Sierra   +8 more
doaj  

Development and production of rabies virus-specific monoclonal antibodies and evaluation of their neutralizing and protective potentials [PDF]

Microbes and Infectious Diseases
Background:  Rabies is a severe viral infection that causes acute encephalomyelitis and has a case fatality rate of almost 100%. There is no cure for symptomatic rabies, but post-exposure prophylaxis (PEP), which comprises vaccines and anti-rabies ...
Rafik Soliman, Zeinb Hashem, Heidy Abo-Elyazeed, Hassan Aboul Ella   +3 more
doaj   +1 more source

Production of autoantibodies by human-human hybridomas.

Journal of Clinical Investigation, 1982
Peripheral blood lymphocytes and splenocytes of patients with autoimmune disease were used to prepare human-human hybridomas that produce autoantibodies. Because exogenous immunization was not used, the hybridoma antibodies were derived from B cells that
Y. Shoenfeld, S. Hsu-Lin, J. Gabriels, L. Silberstein, B. Furie, B. Furie, B. Stollar, R. Schwartz   +7 more
semanticscholar   +1 more source

Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females

The Journal of Physiology, EarlyView.
Abstract figure legend Twenty‐seven pre‐menopausal, untrained females performed a 12‐week resistance training programme to explore the association between androgen concentrations, androgen receptor signalling and skeletal muscle size and strength. Total testosterone was not associated with muscle mass or strength, nor with resistance training‐induced ...
Sarah E. Alexander, Briana Gatto, Olivia E. Knowles, Ross M. Williams, Kinga N. Fiebig, Paul Jansons, Paul A. Della Gatta, Andrew Garnham, Nir Eynon, Glenn D. Wadley, Brad Aisbett, Danielle Hiam, Séverine Lamon   +12 more
wiley   +1 more source