Results 111 to 120 of about 60,260 (340)

Synthetic Cathepsin B Sensitive Adjuvant‐Peptide Conjugates to Target Intracellular Toll‐Like Receptors 7 and 8

ChemistryEurope, EarlyView.
Cathepsin B‐sensitive peptide–adjuvant conjugates are designed, synthesized, and evaluated to deliver an antigenic peptid and an adjuvant targeting Toll‐like receptors 7 and 8 (TLR7/8) to antigen presenting cells. The adjuvant is released by cathepsin B resulting in antigen presentation and TLR mediated T cell activation.
Marjolein M. E. Isendoorn, Giulia Castello, Nico J. Meeuwenoord, Martijn Verdoes, Jeroen D. C. Codée, Ferry Ossendorp, Dmitri V. Filippov   +6 more
wiley   +1 more source

Definition of Drosophila hemocyte subsets by cell-type specific antigens. [PDF]

, 2007
We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria.
Andó, István, Csorba, Kinga, Gateff, Elisabeth, Hultmark, Dan, Kurucz, Éva, Laurinyecz, Barbara, Márkus, Róbert, Vilmos, Péter, Váczi, Balázs, Zsámboki, János   +9 more
core   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Development and characterization of murine monoclonal antibody specific for the P1.4 PorA proteins from strain B:4:P1.(7b).4. of Neisseria meningitidis

VacciMonitor, 2011
Neisseria meningitidis isolates are conventionally classified by serosubtyping that characterizes the reactivities of the PorA outer membrane protein variable-region epitopes with monoclonal antibodies.
María Elena Pérez, Ramón Barberá, Francisco Domínguez , Oscar Otero, Mercedes Gutiérrez, Gustavo Falero, Grethel Reyes, Franklin Sotolongo, Gustavo Sierra   +8 more
doaj  

Important roles for E protein binding sites within the immunoglobulin kappa chain intronic enhancer in activating Vkappa Jkappa rearrangement. [PDF]

, 2004
The immunoglobulin kappa light chain intronic enhancer (iEkappa) activates kappa rearrangement and is required to maintain the earlier or more efficient rearrangement of kappa versus lambda (lambda).
Inlay, Matthew A, Lin, Tongxiang, Tian, Hua, Xu, Yang   +3 more
core  

Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane‐Fly Spermatocytes

Cytoskeleton, EarlyView.
ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos, Maral Janan, Martina Krüger, Aavo‐Valdur Mikelsaar, Arthur Forer, Rose Sheykhani   +5 more
wiley   +1 more source

An ultra scale-down analysis of the recovery by dead-end centrifugation of human cells for therapy. [PDF]

, 2014
An ultra scale-down method is described to determine the response of cells to recovery by dead-end (batch) centrifugation under commercially defined manufacturing conditions.
Delahaye, M, Hoare, M, Lawrence, K, Ward, SJ   +3 more
core   +1 more source

V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice.

Journal of Immunology, 1993
Anti-Sm autoantibodies are unique to SLE, but are present in only 25% of patients with this disease. This response also occurs at a similar frequency in mice of the autoimmune MRL strains.
D. Bloom, J. Davignon, M. Retter, M. Shlomchik, David S. Pisetsky, Philip L. Cohen, Robert A. Eisenberg, Stephen H. Clarke   +7 more
semanticscholar   +1 more source

Searching for Novel Antiviral Agents as COVID19 Treatments: Guanidino Diaryl Thioureas

ChemMedChem, EarlyView.
Structure of the "hit‐compound" found and the proposed interaction with the active site of the TMPRSS2 protease, involving a reversible mechanism of action, are shown. The COVID‐19 pandemic highlighted the urgent need for effective antiviral treatments targeting SARS‐CoV‐2.
Marco Minneci, Barbara Farkaš, Adeyemi Rahman, Amy Kempf, Inga Nehlmeier, Stefan Pöhlmann, Isabel Rozas   +6 more
wiley   +1 more source

Electrochemical Detection of SARS‐CoV‐2 in Saliva Using ZnO Nanorods Functionalized with Gold‐Conjugated Antireceptor‐Binding Domain Antibodies

ChemNanoMat, EarlyView.
An electrochemical immunosensor based on ZnO nanorods functionalized with gold nanoparticle‐conjugated anti‐receptor‐binding domain antibodies enables rapid, noninvasive, and selective detection of SARS‐CoV‐2 in saliva, providing a promising platform for point‐of‐care diagnostic applications.
Fabíola Lelis de Castro, Ana Cristina Honorato Castro‐Kochi, Marcos Roberto de Araújo Silva, Priscila Sabbag Ferreira, Sydney Ferreira Santos, Lídia Maria de Andrade, Mariano Venanzi, Francesca Cavalieri, Mariângela de Oliveira Silva, Isabela Pazotti Daher, Catarina Harumi Oda Ibrahim, Vivian Leite de Oliveira, Jorge Kalil, Tamires Lopes Silva, Silvia Beatriz Boscardin, Wendel Andrade Alves   +15 more
wiley   +1 more source