Results 121 to 130 of about 59,735 (325)

Acute introduction of monomeric or multimeric α‐synuclein induces distinct impacts on synaptic vesicle trafficking at lamprey giant synapses

The Journal of Physiology, EarlyView.
Abstract figure legend Monomeric and multimeric α‐synuclein were purified from HEK cells and delivered to lamprey reticulospinal (RS) synapses via axonal microinjection, followed by stimulation (20 Hz, 5 min). Ultrastructural analysis showed that both α‐synuclein species impaired intracellular vesicle trafficking, leading to synaptic vesicle loss and ...
Cristina Román‐Vendrell, Jaqulin N. Wallace, Aurelia Hays Watson, Meral Celikag, Tim Bartels, Jennifer R. Morgan   +5 more
wiley   +1 more source

Complete dissection of the Hb(64-76) determinant using T helper 1, T helper 2 clones, and T cell hybridomas.

Journal of Immunology, 1992
We have generated cloned Th1 cells, Th2 cells, and T cell hybridomas specific for the single immunogenic peptide from the beta-chain of murine hemoglobin (Hb(64-76)). The availability of these various types of T cells provided us an unique opportunity to
B. Evavold, S. G. Williams, B. L. Hsu, S. Buus, P. Allen   +4 more
semanticscholar   +1 more source

Volitional exercise elicits physiological and molecular improvements in the severe D2.mdx mouse model of Duchenne muscular dystrophy

The Journal of Physiology, EarlyView.
Abstract figure legend This study investigated the effects of volitional exercise on muscle health in the more severe D2.mdx model of Duchenne muscular dystrophy (DMD). We showed that 8–10 weeks of a relatively high volume of voluntary wheel running (VWR) in D2.mdx animals augmented select muscle mass and normalized ex vivo muscle force compared to ...
Stephanie R. Mattina, Sean Y. Ng, Andrew I. Mikhail, Derek W. Stouth, Cora E. Jornacion, Irena A. Rebalka, Thomas J. Hawke, Vladimir Ljubicic   +7 more
wiley   +1 more source

Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors

Cell Reports, 2018
Summary: The pathogenic potential of Mycobacterium tuberculosis largely depends on ESX secretion systems exporting members of the multigenic Esx, Esp, and PE/PPE protein families.
Fadel Sayes, Catherine Blanc, Louis S. Ates, Nathalie Deboosere, Mickael Orgeur, Fabien Le Chevalier, Matthias I. Gröschel, Wafa Frigui, Ok-Ryul Song, Richard Lo-Man, Florence Brossier, Wladimir Sougakoff, Daria Bottai, Priscille Brodin, Pierre Charneau, Roland Brosch, Laleh Majlessi   +16 more
doaj  

B cell growth factors and B cell differentiation factor from human T hybridomas. Two distinct kinds of B cell growth factor and their synergism in B cell proliferation

Journal of Experimental Medicine, 1983
Human T hybridomas secreting B cell growth factors (BCGF) and B cell differentiation factor (BCDF) have been established. Hybrid clones 77- A, 94-C, and 98-F secreted BCGF that induced proliferation of anti-IgM- stimulated normal B cells.
Masaji Okada, Nobuo Sakaguchi, N. Yoshimura, Hideki Hara, Kazuo Shimizu, Nobuaki Yoshida, Kazuyuki Yoshizaki, Susumu Kishimoto, Yuichi Yamamura, Tadamitsu Kishimoto   +9 more
semanticscholar   +1 more source

Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females

The Journal of Physiology, EarlyView.
Abstract figure legend Twenty‐seven pre‐menopausal, untrained females performed a 12‐week resistance training programme to explore the association between androgen concentrations, androgen receptor signalling and skeletal muscle size and strength. Total testosterone was not associated with muscle mass or strength, nor with resistance training‐induced ...
Sarah E. Alexander, Briana Gatto, Olivia E. Knowles, Ross M. Williams, Kinga N. Fiebig, Paul Jansons, Paul A. Della Gatta, Andrew Garnham, Nir Eynon, Glenn D. Wadley, Brad Aisbett, Danielle Hiam, Séverine Lamon   +12 more
wiley   +1 more source

Inhibition of ErbB2 mitigates secondary denervation after traumatic muscle injury

The Journal of Physiology, EarlyView.
Abstract figure legend Our study evaluated the therapeutic potential of ErbB2 inhibition (Herceptin) after volumetric muscle loss (VML) injury, primarily evaluating improvements at the neuromuscular junctions (NMJ). A full thickness model of VML injury to the tibialis anterior muscle of adult Lewis rats was used, and treatments included Herceptin, a ...
Jacob R. Sorensen, Daniel B. Hoffman, Christiana J. Raymond‐Pope, Thomas J. Lillquist, Amanda M. Russell, Benjamin T. Corona, Sarah M. Greising   +6 more
wiley   +1 more source

Bispecific antibodies and their use in applied research

Veterinary World, 2012
Bispecific antibodies (BsAb) can, by virtue of combining two binding specificities, improve the selectivity and efficacy of antibody-based treatment of human disease.
Harshit Verma, Durairajan Ramachandran, Ashabaree Samal   +2 more
doaj   +1 more source

Important roles for E protein binding sites within the immunoglobulin kappa chain intronic enhancer in activating Vkappa Jkappa rearrangement. [PDF]

, 2004
The immunoglobulin kappa light chain intronic enhancer (iEkappa) activates kappa rearrangement and is required to maintain the earlier or more efficient rearrangement of kappa versus lambda (lambda).
Inlay, Matthew A, Lin, Tongxiang, Tian, Hua, Xu, Yang   +3 more
core  

Inhibition of Influenza-Immune T Cell Effector Function by Virus-Specific Hybridoma Antibody [PDF]

, 1979
Rita B. Effros, Mark Frankel, Walter Gerhard, Peter C. Doherty   +3 more
openalex   +1 more source