Results 121 to 130 of about 45,417 (262)
Production of CD4⁺ and CD8⁺ T cell hybridomas.
D. Canaday
semanticscholar +1 more source
Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors
ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings +6 more
wiley +1 more source
J. Snick +6 more
semanticscholar +1 more source
Aging Reshapes γ/δ T‐Cell Immunity Through a Type I Interferon–Foxo1 Axis
Aging reshapes the peripheral γ/δ T‐cell compartment by promoting the expansion and enhanced IL‐17–driven activity of innate‐like γ/δ T cells in secondary lymphoid organs. This remodeling is controlled by type I interferon–dependent downregulation of Foxo1, linking aging to heightened pro‐inflammatory γ/δ T‐cell responses.
Aurélie Durand +7 more
wiley +1 more source
A rapid glass‐substrate 3D microfabrication method creates anatomically accurate carotid artery‐on‐a‐chip models from stroke patient scans in 2 h. These miniaturized devices replicate patient‐specific blood vessel geometry and flow patterns, enabling real‐time imaging of clot formation under controlled injury.
Yunduo Charles Zhao +14 more
wiley +1 more source
The modular, versatile, and standardized cartridge‐based culture module allows to replicate gut and vascular barriers. Its conventional handling requirements facilitate adoption by non‐technical users, while the design allows safe manipulation and retrieval of samples for permeability assays and endpoint analysis.
Lorenzo Pietro Coppadoro +6 more
wiley +1 more source
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack +13 more
wiley +1 more source
Monoclonal antibodies (mAbs) against Fusion (F)2 protein of Newcastle disease virus (NDV) wereproduced for the detection of the viral antigen in infected chickens.
Nyoman Mantik Astawa +1 more
doaj

