Results 71 to 80 of about 59,780 (293)

B cell growth factors and B cell differentiation factor from human T hybridomas. Two distinct kinds of B cell growth factor and their synergism in B cell proliferation

Journal of Experimental Medicine, 1983
Human T hybridomas secreting B cell growth factors (BCGF) and B cell differentiation factor (BCDF) have been established. Hybrid clones 77- A, 94-C, and 98-F secreted BCGF that induced proliferation of anti-IgM- stimulated normal B cells.
Masaji Okada, Nobuo Sakaguchi, N. Yoshimura, Hideki Hara, Kazuo Shimizu, Nobuaki Yoshida, Kazuyuki Yoshizaki, Susumu Kishimoto, Yuichi Yamamura, Tadamitsu Kishimoto   +9 more
semanticscholar   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Design and Evaluation of Eb4Mab‐7‐mG2a: A Dual‐Action Anti‐EphB4 Monoclonal Antibody for Targeted Breast Cancer Therapy

Cancer Science, EarlyView.
Eb4Mab‐7‐mG2a, an anti‐EphB4 monoclonal antibody, significantly suppressed tumor growth in the MCF‐7 xenograft model. Tumor volume and weight were markedly reduced in treated mice, demonstrating its antitumor efficacy against EphB4‐positive breast cancer.
Tomokazu Ohishi, Hiroyuki Suzuki, Mika K. Kaneko, Tomohiro Tanaka, Akiko Harakawa, Junjiro Yoshida, Daisuke Tatsuda, Yukinari Kato, Manabu Kawada   +8 more
wiley   +1 more source

Inhibition of Influenza-Immune T Cell Effector Function by Virus-Specific Hybridoma Antibody [PDF]

, 1979
Rita B. Effros, Mark Frankel, Walter Gerhard, Peter C. Doherty   +3 more
openalex   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Retinoic acids inhibit activation-induced apoptosis in T cell hybridomas and thymocytes.

Journal of Immunology, 1992
Apoptosis is induced in immature thymocytes and T cell hybridomas upon stimulation via the TCR/CD3 complex. This phenomenon appears to be related to negative selection of T cell clones in the thymus.
M. Iwata, M. Mukai, Y. Nakai, R. Iseki
semanticscholar   +1 more source

Antibody Polyreactivity: A Challenger of Immune Paradigms

Immunology, EarlyView.
This review article discusses the definition and functions of polyreactive antibodies, as well as their physiological roles. It also presents the concept of polyreactivity as a challenger of immunological dogmas. ABSTRACT Polyreactivity refers to the ability of antibodies to bind multiple unrelated antigens, encompassing polyspecificity and promiscuity.
Anastas D. Pashov, Jordan D. Dimitrov
wiley   +1 more source

Activation of acceptor-suppressor hybridoma with antigen-specific suppressor T cell factor of two-chain type: requirement of the antigen- and the I-J-restricting specificity. [PDF]

, 1984
Takayuki Sumida, Izumi Takei, Mitsutaka Taniguchi   +2 more
openalex   +1 more source

Complete dissection of the Hb(64-76) determinant using T helper 1, T helper 2 clones, and T cell hybridomas.

Journal of Immunology, 1992
We have generated cloned Th1 cells, Th2 cells, and T cell hybridomas specific for the single immunogenic peptide from the beta-chain of murine hemoglobin (Hb(64-76)). The availability of these various types of T cells provided us an unique opportunity to
B. Evavold, S. G. Williams, B. L. Hsu, S. Buus, P. Allen   +4 more
semanticscholar   +1 more source

Concomitant induction of the cell surface expression of Ia determinants and accessory cell function by a murine macrophage tumor cell line. [PDF]

, 1982
This study demonstrates that an uncharacterized soluble factor produced in concanavalin A-induced rat spleen cell suspensions has the capacity to induce the increased expression of cell surface H-2K and H-2D molecules and the expression of I-region gene ...
Lanier, LL, Walker, EB, Warner, NL
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