Results 1 to 10 of about 4,421 (175)

Novel Dual 5-HT₇ Antagonists and Sodium Channel Inhibitors as Potential Therapeutic Agents with Antidepressant and Anxiolytic Activities [PDF]

Pharmaceuticals
Background/Objectives: The study aimed to pharmacologically evaluate dually acting ligands, 5-HT7 antagonists and sodium channel inhibitors, as potential therapeutic agents for the treatment of depression, anxiety, and neuropathic pain. The designed dual
Anna Czopek, Paulina Koczurkiewicz-Adamczyk, Katarzyna Wójcik-Pszczoła, Daria Kornas, Wojciech Sitko, Adam Bucki, Michał Sapa, Krzysztof Kamiński, Grzegorz Satała, Beata Duszyńska, Andrzej J. Bojarski, Gniewomir Latacz, Jacek Czopek, Joanna Szpor, Pola Dryja, Kinga Sałat   +15 more
doaj   +2 more sources

Recent Applications of Hydantoins in Drug Discovery: Updates (2019~Present) [PDF]

Molecules
Hydantoins, exemplified by the imidazolidine-2,4-dione core, are privileged scaffolds in medicinal chemistry due to their compact structure, versatile hydrogen-bonding capacity, ability to fine-tune physicochemical properties for drug-like molecules, and
Jyoti Dnyaneshwar Palkhede, Eo-Jin Park, Om Darlami, Dongyun Shin   +3 more
doaj   +2 more sources

Design, Synthesis, Bioevaluation, and Bioinformatics Study of 5‐Benzylidene Hydantoin Derivatives as Novel Tyrosine Kinase Inhibitors [PDF]

ChemistryOpen
Tyrosine kinases regulate cellular growth, differentiation, and metabolism, and their dysregulation is implicated in malignancies, making them therapeutic targets.
Muhammad Naufal, Elvira Hermawati, Ade Danova, Ika Wiani Hidayat, Jamaludin Al‐Anshori   +4 more
doaj   +2 more sources

Hydantoin Derivatives of L- and D-amino acids: Synthesis and Evaluation of Their Antiviral and Antitumoral Activity

Molecules, 2006
3,5-Disubstituted hydantoin (1,3-imidazolidinedione) derivatives 5a-h wereprepared by base induced cyclization of the corresponding N-(1-benzotriazolecarbonyl)-L-and D-amino acid amides 4a-h.
Branka Zorc, Silvana Raić-Malić, Marijeta Kralj   +2 more
exaly   +3 more sources

Facile synthesis of hydantoin/1,2,4-oxadiazoline spiro-compounds via 1,3-dipolar cycloaddition of nitrile oxides to 5-iminohydantoins [PDF]

Beilstein Journal of Organic Chemistry
The cycloaddition of 1,3-dipoles at C=N bonds is a relatively rare process, in contrast to the widespread cycloaddition reactions at C=C, C≡C, and C=S bonds.
Juliana V. Petrova, Varvara T. Tkachenko, Victor A. Tafeenko, Anna S. Pestretsova, Vadim S. Pokrovsky, Maxim E. Kukushkin, Elena K. Beloglazkina   +6 more
doaj   +2 more sources

Sequential two-step, one-pot microwave-assisted Urech synthesis of 5-monosubstituted hydantoins from L-amino acids in water [PDF]

Beilstein Journal of Organic Chemistry
The hydantoin scaffold is renowned for its wide-ranging biological activities, including antibacterial, antiviral, anticancer, anti-inflammatory, and anticonvulsant effects.
Wei-Jin Chang, Sook Yee Liew, Thomas Kurz, Siow-Ping Tan   +3 more
doaj   +2 more sources

Hydantoins: Synthesis, properties and anticonvulsant activity [PDF]

Hemijska Industrija, 2009
Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical
Trišović Nemanja P., Ušćumlić Gordana S., Petrović Slobodan D.   +2 more
doaj   +1 more source

3′-Aminothiocyclohexanespiro-5′-hydantoin and Its Pt(II) Complex—Synthesis, Cytotoxicity and Xanthine Oxidase Inhibitory Activity

Inorganics, 2022
Herein, we report the synthesis of platinum(II) complex bearing 3′-aminothiocyclohexanespiro-5′-hydantoin as ligand. The complex was characterized by IR, NMR spectral analyses, elemental analyses and density functional theory (DFT) calculations ...
Emiliya Cherneva, Mariyana Atanasova, Žaklina Šmelcerović, Katarina Tomović, Rossen Buyukliev, Andrija Šmelcerović, Adriana Bakalova   +6 more
doaj   +1 more source

Hydantoin and hydrogen-bonding patterns in hydantoin derivatives [PDF]

Acta Crystallographica Section C Crystal Structure Communications, 2004
The structure of hydantoin (imidazolidine-2,4-dione), C3H4N2O2, has been determined from a twinned crystal. The two carbonyl bond lengths are nearly equal, even though one of them adjoins electron-donating NH groups to either side while the other is adjacent to only one.
Fang-Lei, Yu, Carl H, Schwalbe, David J, Watkin   +2 more
openaire   +2 more sources

3-(4-Chlorophenylsulfonyl)-8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione

Acta Crystallographica Section E, 2009
In the title compound, C15H17ClN2O4S, the atoms in the hydantoin ring are coplanar (r.m.s. deviation = 0.006 Å). The crystal structure is stabilized by intermolecular N—H...O hydrogen bonds which link the molecules into ...
M. Kalim Kashif, M. Khawar Rauf, Michael Bolte, Shahid Hameed   +3 more
doaj   +1 more source