Results 51 to 60 of about 4,421 (175)

Two siblings with fetal hydantoin syndrome

The Turkish Journal of Pediatrics, 1998
An association between anticonvulsant drugs taken during pregnancy and congenital abnormalities was first identified by Meadow et al. in 1968. Manson and Frederic clarified teratogenic effects of hydantoin in their epidemiological studies in 1973.
F Ozkinay, A Yenigün, M Kantar, C Ozkinay, A Avanoğlu, I Ulman   +5 more
doaj  

Thermotolerant D‐Hydantoinases for Efficient and Stereoselective Intermediate Synthesis of (R)‐3‐Isobutylglutaric Acid Monoamide, a Key Intermediate in Pregabalin Production

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
We engineered thermo‐alkali‐stable D‐hydantoinases via mutagenesis (M63A/F65H/C317T) to resolve Pregabalin's challenging chiral splitting, achieving ee value > 97% for key intermediate (R)‐3‐isobutylglutaric acid monoamide (R‐IBM) synthesis under extreme conditions (pH 10, 70°C–80°C).
Jiujiuzi Zhang, Bin Zhi, Zhenyu Xie, Beibei Zhang, Ning Wang, Wanpeng Wang   +5 more
wiley   +1 more source

Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea

Beilstein Journal of Organic Chemistry, 2019
A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed.
Aleksandr I. Kobelev, Nikita A. Tretyakov, Ekaterina E. Stepanova, Maksim V. Dmitriev, Michael Rubin, Andrey N. Maslivets   +5 more
doaj   +1 more source

Anogenital Contact Dermatitis in Spain: A REIDAC Study of Patients Undergoing Patch Testing in 2019–2024

Contact Dermatitis, Volume 94, Issue 3, Page 272-285, March 2026.
Allergic contact dermatitis is very common in patients with anogenital lesions referred for patch testing in Spain. Key allergens include fragrances, preservatives and topical treatments like anaesthetics and steroids. Emerging sensitisers including benzisothiazolinone and sodium metabisulphite are also relevant.
Mercè Grau‐Pérez, Pedro Mercader‐García, Ana María Giménez‐Arnau, Tatiana Sanz‐Sánchez, Violeta Zaragoza Ninet, Susana Córdoba Guijarro, Francisco Javier Miquel Miquel, Juan Francisco Silvestre Salvador, Ricardo González‐Pérez, Inmaculada Ruíz González, Esther Serra Baldrich, José Manuel Carrascosa, Francisco Javier Ortiz de Frutos, Mercedes Rodríguez Serna, María Elena Gatica Ortega, Carmen Paredes Suárez, Francisco José Navarro Triviño, Pablo Chicharro, Marta Andreu, Araceli Sánchez Gilo, José Juan Pereyra Rodríguez, María Antonia Pastor Nieto, Gemma Melé‐Ninot, Paloma Sánchez‐Pedreño Guillén, Enrique Gómez de la Fuente, Marta Elosua‐González, Mónica Munera‐Campos, Fátima Tous Romero, Miguel Ángel Descalzo, Leopoldo Borrego   +29 more
wiley   +1 more source

3-Amino-5-methyl-5-(4-pyridyl)hydantoin

Acta Crystallographica Section E, 2009
The title compound, 3-amino-5-methyl-5-(4-pyridyl)imidazolidine-2,4-dione, C9H10N4O2, was obtained by reaction of 5-methyl-5-(4-pyridyl)hydantoin with hydrazine.
Alexander Roller, Adriana Bakalova, Rossen Buyukliev, Hristo Varbanov   +3 more
doaj   +1 more source

Propyl-2-(8-(3,4-difluorobenzyl)-2',5'-dioxo-8-azaspiro[bicyclo[3.2.1] octane-3,4'-imidazolidine]-1'-yl) acetate induces apoptosis in human leukemia cells through mitochondrial pathway following cell cycle arrest. [PDF]

PLoS ONE, 2013
BACKGROUND: Due to the functional defects in apoptosis signaling molecules or deficient activation of apoptosis pathways, leukemia has become an aggressive disease with poor prognosis.
Chandagirikoppal V Kavitha, Mridula Nambiar, Pavan B Narayanaswamy, Elizabeth Thomas, Ujjwal Rathore, Channapillekoppalu S Ananda Kumar, Bibha Choudhary, Kanchugarakoppal S Rangappa, Sathees C Raghavan   +8 more
doaj   +1 more source

Highly Substituted 1,4‐Benzodiazepin‐2‐ones: A Rapid Modular Approach From Arynes and Unsymmetrical Imides

ChemistryEurope, Volume 4, Issue 2, February 2026.
In this work, 1,4‐benzodiazepine‐2‐ones are synthesized starting from Kobayashi‐type aryne precursors and amino acid‐derived, unsymmetrical imides. Operationally simple protocols to access both the starting materials and the potential active pharmaceutical ingredients are presented.
Jasper Mindner, Julia Gartzke, Silas Wittmer, Tassilo Segerer, Burkhard Butschke, Daniel B. Werz   +5 more
wiley   +1 more source

Fetal Hydantoin Syndrome

Pediatric Neurology Briefs, 1990
In a prospective study of 19 pregnancies monitored by amniocentesis at the Center for Human Genetics and the Meyer Rehabilitation Institute, University of Nebraska, Omaha, an adverse outcome was predicted for four fetuses on the basis of low epoxide ...
J Gordon Millichap
doaj   +1 more source

3’-Methyl-4-thio-1H-tetrahydropyranspiro-5’-hydantoin platinum complex as a novel deoxyribonuclease I inhibitor [PDF]

Pharmacia
Deoxyribonuclease I (DNase I) is one of the main nucleases involved in deoxyribonucleic acid (DNA) degradation during apoptosis. It catalyzes the hydrolytic cleavage of DNA, producing 5‘-oligonucleotides.
Ana Marković, Mariyana Atanasova, Rossen Buyukliev, Adriana Bakalova, Andrija Šmelcerović, Emiliya Cherneva   +5 more
doaj   +3 more sources

Antiproliferative and antimigratory effects of 3-(4-substituted benzyl)-5- isopropyl-5-phenylhydantoin derivatives in human breast cancer cells

Saudi Pharmaceutical Journal, 2020
In this study, a series of synthesized 3-(4-substituted benzyl)-5-isopropyl-5-phenylhydantoin derivatives as a potential antiproliferative and antimigratory agents were investigated. The possible antitumor mechanisms of investigated hydantoin derivatives
Ana Obradović, Miloš Matić, Branka Ognjanović, Predrag Đurđević, Emilija Marinković, Gordana Ušćumlić, Bojan Božić, Biljana Božić Nedeljković   +7 more
doaj   +1 more source