Hydrazides as Powerful Tools in Medicinal Chemistry: Synthesis, Reactivity, and Biological Applications [PDF]
MoleculesThe increase in drug resistance and the high toxicity of current drugs have inspired the scientific community to develop new drugs for various diseases. Hydrazides have become an attractive functional group to easily obtain a plethora of novel compounds ...
Sofia Teixeira +2 more
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Synthesis and characterization of FeCuAlO4 as a reusable heterogeneous acidic nanocatalyst for preparation of 2-amino-1,3,4-thiadiazole derivatives in water [PDF]
Scientific Reports2-amino-1,3,4-thiadiazole derivatives possess notable significance across therapeutic, agricultural, and industrial domains. The reaction of acid hydrazides and potassium thiocyanate in aqueous solution leads to the production of thiosemicarbazide ...
Abbas Nikoo
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Exploring the Synthesis, Anti-Inflammatory and Anti-Tumor Potential of 4-Maleimidylphenyl-Hydrazide Derivatives. [PDF]
MoleculesCloutier F +8 more
europepmc +3 more sources
Late-stage diversification strategy for the synthesis of peptide acids and amides using hydrazides [PDF]
Exploration of Drug Science, 2023 Aim: Modification of the C-terminus of a peptide to improve its properties, particularly after constructing the peptide chain, has great promise in the development of peptide therapeutics.
Shoko Tanaka +5 more
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Journal of Applied Pharmaceutical Research, 2022 Acid hydrazides are essential intermediates in organic synthesis. They conventionally require a two-step synthetic pathway; esterification and hydrazine hydrate treatment; to obtain the hydrazide. The microwave-assisted synthetic methodology was utilized
Sabah Mohamad +2 more
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Electrochemical Synthesis of Dibenzothiophene S,S-Dioxides from Biaryl Sulfonyl Hydrazides
Electrochemistry, 2023 The electrochemical synthesis of dibenzothiophene S,S-dioxides was achieved by the anodic oxidation of biaryl sulfonyl hydrazides. The use of Bu4NOTf as the electrolyte in HFIP/CH3NO2 (15 : 1) is essential.
Yasuyuki OKUMURA +3 more
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Molecules, 2021 Based on the broad spectrum of biological activity of hydrazide–hydrazones, trifluoromethyl compounds, and clinical usage of cholinesterase inhibitors, we investigated hydrazones obtained from 4-(trifluoromethyl)benzohydrazide and various benzaldehydes ...
Martin Krátký +4 more
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The synthesis and characterization of some novel 5-chloro-2-(substituted alkoxy)-N-phenylbenzamide derivatives [PDF]
Journal of the Serbian Chemical Society, 2009 To obtain biologically active compounds, the synthesis of some new derivatives with an o-hydroxybenzamide structure was performed. The ethyl esters 4–6 were obtained by the reaction of 5-chloro-2-hydroxy-N-phenylbenzamide and chloro-substituted acid ...
IOANA M. C. IENAŞCU +4 more
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Synthesis, Characterization and Antimicrobial Activity of Some New Tetrazole Derivatives from Hydrazones [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2022 In this investigation, a combination of Z1-Z5 hydrazone compounds is obtained from the reaction between 4-methylbenzohydrazide and aryl-aldehydes. A subsequent unique synthetic approach to the preparation of di-substituted tetrazoles T6-T10 was achieved ...
Ahmed Sajjad, Zainab Al Shuhaib
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Hydrazides in the reaction with hydroxypyrrolines: less nucleophilicity – more diversity
Beilstein Journal of Organic Chemistry, 2021 Expedient protocols for the synthesis of three types of highly functionalized azaheterocyclic scaffolds (dihydropyridazines, tetrahydropyridazines, and partially saturated tricyclic systems) from readily available hydroxypyrrolines and hydrazides are ...
Dmitrii A. Shabalin +4 more
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