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25-Hydroxycholesterol Effect on Membrane Structure and Mechanical Properties [PDF]
International Journal of Molecular Sciences, 2021 Cholesterol is responsible for the plasticity of plasma membranes and is involved in physiological and pathophysiological responses. Cholesterol homeostasis is regulated by oxysterols, such as 25-hydroxycholesterol.
Nuno C. Santos +2 more
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7α-Hydroxylation of 25-hydroxycholesterol and 27-hydroxycholesterol in human fibroblasts
Lipids and Lipid Metabolism, 1995The metabolism of 27-hydroxycholesterol and 25-hydroxycholesterol was studied in cultures of human diploid fibroblasts. Both steroids underwent 7 alpha-hydroxylation with subsequent oxidation to 7 alpha-hydroxy-3-oxo-delta 4 steroids. A minor fraction of the 27-hydroxysteroids was oxidized to acids.
Ola Larsson, Jan Sjövall
exaly +3 more sources
Atherosclerosis, 2000 In the present study, we characterize the early cytotoxic effects of 7β-hydroxycholesterol, a major cytotoxin in oxidized LDL, in human aortic smooth muscle cells. Within a few minutes after addition, 7β-hydroxycholesterol induced Ca 2+ oscillations with
Per-Olof Berggren +2 more
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Investigation on the synthesis of 24-(R)-hydroxycholesterol
Steroids, 2023A facile and novel strategy has been developed for synthesis of 24-(R)-hydroxycholesterol, a key intermediate of tacalcitol, starting from 24-dehydrocholesterol in seven steps with 48.2% overall yield and high diastereomer ratio. Photocatalytic oxidation of olefins by employing inexpensive Rose Bengal as photosensitizer and air as the sole oxidant for ...
Haiyun, Zhao +5 more
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General Pharmacology: The Vascular System, 1994
1. The bishemisuccinates of 7 alpha-hydroxycholesterol and 7 beta-hydroxycholesterol induced a dose-dependent decrease in the incorporation of [3H]thymidine into fibroblast cell line (3T3), macrophage-like cell line (P388D1) and rat hepatoma cell line (H35). Concomitantly there was a reduction in cell viability. 2.
W Y, Chan +4 more
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1. The bishemisuccinates of 7 alpha-hydroxycholesterol and 7 beta-hydroxycholesterol induced a dose-dependent decrease in the incorporation of [3H]thymidine into fibroblast cell line (3T3), macrophage-like cell line (P388D1) and rat hepatoma cell line (H35). Concomitantly there was a reduction in cell viability. 2.
W Y, Chan +4 more
openaire +2 more sources
Investigation on the synthesis of 25-hydroxycholesterol
Steroids, 2014A very efficient and environmentally benign method has been developed for the synthesis of 25-hydroxycholesterol. The reaction was performed in THF-water (4:1, v/v) using NBS as the brominating agent, followed by the easy reduction of C-Br with lithium aluminum hydride in THF, to yield the final product corresponding to a Markovnikov's rule.
Qian, Zhao +6 more
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Synthesis of ent-25-hydroxycholesterol
Steroids, 200625-Hydroxycholesterol (25-HC) appears to play a role in several important biological processes, including regulating cellular cholesterol levels and promoting apoptosis. However, in most cases the mechanisms by which 25-HC elicits its biological effects are not known.
Emily J, Westover, Douglas F, Covey
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Synthesis of (25R)-26-hydroxycholesterol
Steroids, 2002We describe the synthesis of (25R)-cholest-5-en-3beta,26-diol ((25R)-26-hydroxycholesterol) from diosgenin in four steps in 58% overall, yield via a modified Clemmensen reduction followed by a Barton deoxygenation reaction.
John R, Williams +2 more
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25-hydroxycholesterol: Gatekeeper of intestinal IgA
Immunity, 2021High levels of cholesterol and diets high in fat are associated with immune dysfunction and inflammatory disease. In this issue of Immunity, Trindade et al. (2021) report how the cholesterol metabolite 25-hydroxycholesterol restrains IgA plasma cell differentiation from germinal-center B cells in the Peyer's patches through regulation of the sterol ...
Christopher J M, Piper, Claudia, Mauri
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