Results 181 to 190 of about 17,936 (215)

Synthesis of 17α-hydroxycholesterol

Steroids, 1970
Abstract The known 16-dehydrocholesterol, upon treatment with a molar equivalent of m-chloroperbenzoic acid, gave in moderate yield the 16α,17α-oxido sterol. Treatment of this oxide with lithium aluminum hydride gave the desired 17α-hydroxycholesterol.
N.K. Chaudhuri, R.C. Nickolson, M. Gut
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Conversion of 20-a-hydroxycholesterol to pregnenolone

Biochemical and Biophysical Research Communications, 1961
20-a-Hydroxycholesterol was first reported by Solomon etal. (1956) to be an intermediate in the conversion of cholesterol to the adrenal steroids. Recently, Shimizu etal. (1960) have reported the formation of labeled isocaproic acid when 20-a-hydroxycholesterol-26-C14 was incubated with soluble adrenal extract in the presence of ATP, Mg++, DPN+, and ...
G, CONSTANTOPOULOS, T T, TCHEN
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Cholesterol, Hydroxycholesterols, and Bile Acids

Biochemical and Biophysical Research Communications, 2002
Although a variety of oxidation products of cholesterol occur in vitro, enzyme-catalyzed oxidations can occur at only 5 sites on the cholesterol molecule: C7alpha, C22R, C24S, C25, and C27. The genes coding for the synthesis of these enzymes were cloned, the tissue expressions of the mRNAs were identified, and the enzymes were characterized.
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Regulation of Hepatocyte Lipid Metabolism and Inflammatory Response by 25‐Hydroxycholesterol and 25‐Hydroxycholesterol‐3‐sulfate

Lipids, 2010
AbstractDysregulation of lipid metabolism is frequently associated with inflammatory conditions. The mechanism of this association is still not clearly defined. Recently, we identified a nuclear oxysterol, 25‐hydroxycholesterol‐3‐sulfate (25HC3S), as an important regulatory molecule involved in lipid metabolism in hepatocytes.
Leyuan, Xu, Qianming, Bai, Daniel, Rodriguez-Agudo, Phillip B, Hylemon, Douglas M, Heuman, William M, Pandak, Shunlin, Ren   +6 more
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Cholesterol and Hydroxycholesterol in the Brain

2011
The brain has higher concentration of cholesterol compared to other body parts (25% of the body’s free cholesterol) (Dietschy and Turley, 2004). In brain, cholesterol resides in two pools: one major pool associated with the myelin sheaths playing an important role in propagation of the electrical signals along the axons and the other minor pool ...
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Bile acid synthesis precursors in familial combined hyperlipidemia: The oxysterols 24S-hydroxycholesterol and 27-hydroxycholesterol

Biochemical and Biophysical Research Communications, 2014
Familial combined hyperlipidemia (FCHL), the most common inherited disorder of lipid metabolism is characterized by increasing cholesterol synthesis precursors due to hepatic overproduction of cholesterol. The bile acids synthesis pathway has not been previously studied in FCHL.
Lucía, Baila-Rueda, Rocío, Mateo-Gallego, Estibaliz, Jarauta, Isabel, de Castro-Orós, Ana M, Bea, Ana, Cenarro, Fernando, Civeira   +6 more
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25-Hydroxycholesterols in innate and adaptive immunity

Nature Reviews Immunology, 2014
Cholesterol and components of the cholesterol biosynthetic pathway have fundamental roles in all mammalian cells. Hydroxylated forms of cholesterol are now emerging as important regulators of immune function. This involves effects on the cholesterol biosynthetic pathway and cell membrane properties, which can have antiviral and anti-inflammatory ...
Jason G, Cyster, Eric V, Dang, Andrea, Reboldi, Tangsheng, Yi   +3 more
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Breast cancer and (25R)-26-hydroxycholesterol

Steroids, 2015
(25R)-26-Hydroxycholesterol (27-hydroxycholesterol) has been found to accumulate in breast tissue and to stimulate tumor growth via the estrogen receptor. Although most tissues express CYP27A1, the highest levels are in macrophages and most attention had been given to the production of 27-hydroxycholesterol in sub-endothelial macrophages as part of ...
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Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice

The AAPS Journal, 2018
Cytochrome P450 3A (CYP3A) enzymes metabolize approximately half of all drugs on the market. Since the endogenous compounds 4β-hydroxycholesterol (4β-HC) and 25-hydroxycholesterol (25-HC) are generated from cholesterol via CYP3A enzymes, we examined whether the plasma levels of 4β-HC and 25-HC reflect hepatic CYP3A4 activity by using a CYP3A-humanized ...
Shin-Ichiro, Nitta, Mari, Hashimoto, Yasuhiro, Kazuki, Shoko, Takehara, Hiraku, Suzuki, Mitsuo, Oshimura, Hidetaka, Akita, Kan, Chiba, Kaoru, Kobayashi   +8 more
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27‐Hydroxycholesterol Exacerbates the Pathogenesis of Asthma

Immunology
ABSTRACT 27‐Hydroxycholesterol (27‐HC) is an oxidative metabolite of cholesterol and an oxysterol catalysed by the mitochondrial cytochrome P450 enzyme, sterol 27‐hydroxylase (CYP27A1). In addition to inducing the release of eosinophil chemotactic factors such as RANTES and Eotaxin, 27‐HC enhances the differentiation of lung ...
Ya Li, Xingyue Liu, Feifei Shang, Minzhu Niu, Jiaqi Yan, Minyu Xie, Xiangnan Tao, Han Huang, Wenwen Wu, Shu Dong, Yingzi Chen, Fan Wu, Shujun Guo, Yulin Du, Mengqing Hua, Chuanwang Song   +15 more
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