Results 1 to 10 of about 1,976 (187)

Broad susceptibility of Candida auris strains to 8-hydroxyquinolines and mechanisms of resistance [PDF]

mBio, 2023
The fungal pathogen Candida auris represents a severe threat to hospitalized patients. Its resistance to multiple classes of antifungal drugs and ability to spread and resist decontamination in healthcare settings make it especially dangerous.
Matthew B. Lohse, Matthew T. Laurie, Sophia Levan, Naomi Ziv, Craig L. Ennis, Clarissa J. Nobile, Joseph DeRisi, Alexander D. Johnson   +7 more
doaj   +2 more sources

Correction: Saadeh et al. Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines. Molecules 2020, 25, 4321 [PDF]

Molecules, 2022
The author wishes to make the following correction to this paper [...]
Haythem A. Saadeh, Kamal A. Sweidan, Mohammad S. Mubarak   +2 more
doaj   +2 more sources

Optimization of Zinc and Aluminum Hydroxyquinolines for Applications as Semiconductors in Molecular Electronics [PDF]

Molecules
This work explores the dispersed heterojunction of tris-(8-hydroxyquinoline) aluminum (AlQ3) and 8-hydroxyquinoline zinc (ZnQ2) with tetracyanoquinodimethane (TCNQ) and 2,6-diaminoanthraquinone (DAAq).
María Elena Sánchez Vergara, Francisco Iñaki Díaz Morales, Bertha Molina, Edgar Alvarez-Zauco, Lourdes Bazán-Díaz, Roberto Salcedo   +5 more
doaj   +2 more sources

A [3+3] Aldol-S_NAr-Dehydration Approach to 2-Naphthol and 7-Hydroxyquinoline Derivatives [PDF]

Molecules
A one-pot [3+3] aldol-SNAr-dehydration annulation sequence was utilized to fuse hindered phenols onto aromatic substrates. The transformation joins doubly activated 1,3-disubstituted acetone derivatives (dinucleophiles) with C5-activated 2 ...
Kwabena Fobi, Ebenezer Ametsetor, Richard A. Bunce   +2 more
doaj   +2 more sources

HIF-Dependent NFATC1 Activation Upregulates ITGA5 and PLAUR in Intestinal Epithelium in Inflammatory Bowel Disease

Frontiers in Genetics, 2021
Intestinal epithelial cells exist in physiological hypoxia, leading to hypoxia-inducible factor (HIF) activation and supporting barrier function and cell metabolism of the intestinal epithelium.
Evgeny Knyazev, Diana Maltseva, Maria Raygorodskaya, Maxim Shkurnikov, Maxim Shkurnikov, Maxim Shkurnikov   +5 more
doaj   +1 more source

Toluene Dioxygenase-Catalyzed cis-Dihydroxylation of Quinolines: A Molecular Docking Study and Chemoenzymatic Synthesis of Quinoline Arene Oxides

Frontiers in Bioengineering and Biotechnology, 2021
Molecular docking studies of quinoline and 2-chloroquinoline substrates at the active site of toluene dioxygenase (TDO), were conducted using Autodock Vina, to identify novel edge-to-face interactions and to rationalize the observed stereoselective cis ...
Derek R. Boyd, Narain D. Sharma, Pui L. Loke, Jonathan G. Carroll, Paul J. Stevenson, Patrick Hoering, Christopher C. R. Allen   +6 more
doaj   +1 more source

Effect of 8-hydroxyquinoline and derivatives on human neuroblastoma SH-SY5Y cells under high glucose [PDF]

PeerJ, 2016
8-Hydroxyquinoline and derivatives exhibit multifunctional properties, including antioxidant, antineurodegenerative, anticancer, anti-inflammatory and antidiabetic activities.
Wilasinee Suwanjang, Supaluk Prachayasittikul, Virapong Prachayasittikul   +2 more
doaj   +2 more sources

Synthesis and Antimicrobial Activity of Novel Substituted Ethyl 2-(Quinolin-4-yl)-propanoates

Molecules, 2013
Substituted 4-hydroxyquinolines were synthesized from anilines and diethyl 2-(ethoxymethylene)malonate by the Gould-Jacobs reaction via cyclization of the intermediate anilinomethylenemalonate followed by hydrolysis and decarboxylation.
Yong Zhou, Kim Drummond Rainsford, Keith Miller, M. Akram Khan   +3 more
doaj   +1 more source

Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines

Molecules, 2020
Compounds containing the 8-hydroxyquinoline (8-HQ) 1 nucleus exhibit a wide range of biological activities, including antimicrobial, anticancer, and antifungal effects.
Haythem A. Saadeh, Kamal A. Sweidan, Mohammad S. Mubarak   +2 more
doaj   +1 more source

Vanadium(IV) Complexes with Methyl-Substituted 8-Hydroxyquinolines: Catalytic Potential in the Oxidation of Hydrocarbons and Alcohols with Peroxides and Biological Activity

Molecules, 2021
Methyl-substituted 8-hydroxyquinolines (Hquin) were successfully used to synthetize five-coordinated oxovanadium(IV) complexes: [VO(2,6-(Me)2-quin)2] (1), [VO(2,5-(Me)2-quin)2] (2) and [VO(2-Me-quin)2] (3).
Joanna Palion-Gazda, André Luz, Luis R. Raposo, Katarzyna Choroba, Jacek E. Nycz, Alina Bieńko, Agnieszka Lewińska, Karol Erfurt, Pedro V. Baptista, Barbara Machura, Alexandra R. Fernandes, Lidia S. Shul’pina, Nikolay S. Ikonnikov, Georgiy B. Shul’pin   +13 more
doaj   +1 more source