Results 21 to 30 of about 6,933 (234)
Synthesis and biological characterization of organoruthenium complexes with 8-hydroxyquinolines [PDF]
, 2018 In this study we report the synthesis, characterization and a thorough biological evaluation of twelve organoruthenium–8-hydroxyquinolinato (Ru-hq) complexes. The chosen hqH ligands bear various halogen atoms in different positions which enables to study
Bai, Yang +7 more
core +6 more sources
Two-Metal Ion-Dependent Enzymes as Potential Antiviral Targets in Human Herpesviruses
mBio, 2022 The majority of drug discovery efforts against herpesviruses have focused on nucleoside analogs that target viral DNA polymerases, agents that are associated with dose-limiting toxicity and/or a narrow spectrum of activity.
Katherine A. DiScipio +6 more
doaj +1 more source
Dihydropyrimidine-thiones and clioquinol synergize to target beta-amyloid cellular pathologies through a metal-dependent mechanism [PDF]
, 2017 The lack of therapies for neurodegenerative diseases arises from our incomplete understanding of their underlying cellular toxicities and the limited number of predictive model systems.
Barrasa, M. Inmaculada +9 more
core +1 more source
Tạp chí Khoa học Đại học Huế: Khoa học Tự nhiên, 2020 In this work, a theoretical study for platinum(II)-8-hydroxyquinoline-tetrylene complexes [{PtCl–C9H6NO}–NHEPh] (Pt–EPh) is carried out for the first time by using the density functional theory (DFT).
Huynh Thi Phuong Loan +2 more
doaj +1 more source
Molecules, 2021 Despite the common use of salens and hydroxyquinolines as therapeutic and bioactive agents, their metal complexes are still under development. Here, we report the synthesis of novel mixed-ligand metal complexes (MSQ) comprising salen (S), derived from (2,
Badriah Saad Al-Farhan +7 more
doaj +1 more source
, 2014 Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust +15 more
core +2 more sources
High-throughput screening with the Eimeria tenella CDC2-related kinase2/cyclin complex EtCRK2/EtCYC3a [PDF]
, 2012 The poultry disease coccidiosis, caused by infection with Eimeria spp. apicomplexan parasites, is responsible for enormous economic losses to the global poultry industry.
Aziz +12 more
core +1 more source
Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals [PDF]
, 2018 The lack of information regarding the mechanisms of action (MoA) or specific molecular targets of phenotypically active compounds can prove a barrier to their development as chemotherapeutic agents.
Fairlamb, Alan +10 more
core +2 more sources
Syntheses, transformations and applications of aminonaphthol derivatives prepared via modified Mannich reactions [PDF]
, 2013 A special alteration is the three-component modi fi ed Mannich reaction (mMR), in which formaldehyde is replaced by an aromatic aldehyde, the secondary amine by ammonia, and the C e H acid by an electron-rich aromatic compound such as 1- or 2 ...
Fülöp, Ferenc, Szatmári, István
core +1 more source
Synthesis of 4-Alkoxy-8-hydroxyquinolines [PDF]
The Journal of Organic Chemistry, 2007 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Juha P, Heiskanen +5 more
openaire +2 more sources