Results 51 to 60 of about 1,148,359 (296)
Advanced Science, EarlyView.This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang +12 more
wiley +1 more source
Hyper-Kamiokande physics opportunities
, 2013 We propose the Hyper-Kamiokande (Hyper-K) detector as a next generation un- derground water Cherenkov detector. It will serve as a far detector of a long base- line neutrino oscillation experiment envisioned for the upgraded J-PARC beam, and as a ...
Group, the Hyper-Kamiokande Working +1 more
core +1 more source
Dynamic Active Constraints for Hyper-Redundant Flexible Robots [PDF]
, 2009 In robot-assisted procedures, the surgeon's ability can be enhanced by navigation guidance through the use of virtual fixtures or active constraints. This paper presents a real-time modeling scheme for dynamic active constraints with fast and simple mesh adaptation under cardiac deformation and changes in anatomic structure. A smooth tubular pathway is
Ka-Wai Kwok +7 more
openaire +4 more sources
Advanced Science, EarlyView.ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang +9 more
wiley +1 more source
C-Space Compression for Robots Motion Planning
International Journal of Advanced Robotic Systems, 2013 Exact motion planning for hyper-redundant robots under complex constraints is computationally intractable. This paper does not deal with the optimization of motion planning algorithms, but rather with the simplification of the configuration space ...
Oded Medina +3 more
doaj +1 more source
Applied Sciences, 2022 Robotic inspection and maintenance are gaining importance due to the number of different scenarios in which robots can operate. The use of robotic systems to accomplish such tasks has deep implications in terms of safety for human workers and can ...
Carlo Canali +7 more
doaj +1 more source
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
Jixie chuandong, 2013 Hyper redundant robotis such robotwith degreesof freedom far more than itsminimum number of degrees of freedom needed to complete a task.The inverse solution of the hyper-redundant robot is obtained by using the method of backbone curve and the formula ...
赵爽, 李立, 白瑞松
doaj
Applied Sciences, 2022 Hyper-redundant manipulators are widely used in minimally invasive surgery because they can navigate through narrow passages in passive compliance with the human body. Although their stability and dexterity have been significantly improved over the years,
Seongil Kwon +3 more
doaj +1 more source
Advanced Science, EarlyView.Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji +13 more
wiley +1 more source