Results 61 to 70 of about 1,406,587 (292)

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

A worm-inspired new spatial hyper-redundant manipulator

, 2010
SUMMARYIn this work a novel spatial hyper-redundant manipulator inspired in the motions of the worms is introduced. The displacement analysis is presented in a semi-closed form solution, whereas the velocity and acceleration analyses are carried out by ...
Raúl Lesso-Arroyo, Jaime Gallardo-Alvarado, J. Santos García-Miranda   +2 more
core   +1 more source

Patient‐Derived Glioblastoma Organoids for AI‐Guided Prediction of Therapeutic Response

Advanced Science, EarlyView.
Patient‐derived glioblastoma organoids provide clinically relevant models that preserve tumor heterogeneity and enable integrated AI‐driven analysis of imaging, molecular, and treatment‐response data. Their convergence with advanced analytics supports predictive, personalized therapeutic strategies and may accelerate translation from patient‐specific ...
Sandbhor Puja, Arun Bhavyadharshini, John Geofrey, Mudliyar Siddharth, Ghanekar Shubham, Moyiadi Aliasgar, Shetty Prakash, Singh Vikas, Sadwani Nidhisha, Garg Akshohini, Sahay Ayushi, Chatterjee Abhishek, Epari Sridhar, Gupta Tejpal, Dasgupta Archya, Goda Jayant   +15 more
wiley   +1 more source

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O‐GlcNAcylation‐Induced m6A Demethylation of HRAS

Advanced Science, EarlyView.
Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Jia‐Xin Yin, Yan‐Lai Zhang, Qun Liu, Rui Liu, Hai‐Yang Yuan, Sui‐Dan Chen, Ming‐Hua Zheng, Kai Wang, Ni Tang, Ai‐Long Huang   +9 more
wiley   +1 more source

From Artificial to Embodied and Physical Intelligence in Smart Manufacturing

Advanced Science, EarlyView.
Smart manufacturing is reframed through complementary artificial, embodied, and physical intelligence, spanning computational reasoning, perception‐action coupling, and material‐level adaptation. Their integration across design, fabrication, operation, and maintenance reveals how intelligence can be co‐designed across algorithms, embodied agents, and ...
Kang Wang, Xinyu Lu, Tong Liu, Jinjie Fang, Xin Li, Siqian Wu, Liuchao Jin, Wei‐Hsin Liao, Shuyou Zhang, Jianrong Tan   +9 more
wiley   +1 more source

Device Stochasticity Directly Implements Bayesian Sampling in Spiking Neurons

Advanced Science, EarlyView.
Brain‐inspired stochastic spiking turns device noise into Bayesian uncertainty for robust, low‐power neuromorphic computing. ABSTRACT Device stochasticity is considered a non‐ideality in neuromorphic hardware, although stochastic neural activity supports probabilistic computation in biological systems.
Huannan Zheng, Jingli Liu, Kezhou Yang
wiley   +1 more source

模块化混联超冗余度机器人的位置正解研究

Jixie chuandong, 2012
A method for the forward position solution of the modular hybrid hyper-redundant robot is presented.The symbolic solution for the forward position of basic module 3-RPS parallel manipulator is obtained by using the Sylvester resultant elimination method ...
刘银龙, 李立, 王蕴华, 谢进, 陈永   +4 more
doaj  

Distributed position control method for a hyper-redundant modular manipulator

, 2002
According to multi-agent system theory and characteristics of the structural distribution of hyper-redundant modular manipulator, we establish the distributed control system for hyper-redundant modular manipulator.
Tan DL(谈大龙), Liu MY(刘明尧), Jiang, WS   +2 more
core  

Hybrid Two‐Step Inkjet Printing and Dip‐Coating Enable Scalable 30%‐Efficient Perovskite/Silicon Tandem Solar Cells

Advanced Energy Materials, EarlyView.
Adopting a scalable hybrid two‐step deposition process route, textured perovskite/silicon tandem solar cells achieve over 30% power‐conversion efficiency. The process route replaces all non‐scalable spin‐coating steps, including organic precursor deposition, self‐assembled monolayer formation, and passivation layer deposition, with scalable techniques ...
Raphael Pesch, Lena P. Rothbauer, Johannes Schenk, Lingyi Fang, Theresa Kuechle, Julian Petry, Uma K. Dangudubiyyam, Richard Thelen, David B. Ritzer, Ting Pan, Daniel O. Baumann, Mohammad Gholipoor, Tonghan Zhao, Nils W. Rosemann, Jinzhao Li, Ulrich Lemmer, Ulrich W. Paetzold   +16 more
wiley   +1 more source