Results 61 to 70 of about 18,674 (285)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

open access: yesAdvanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong   +5 more
wiley   +1 more source

C-Space Compression for Robots Motion Planning

open access: yesInternational Journal of Advanced Robotic Systems, 2013
Exact motion planning for hyper-redundant robots under complex constraints is computationally intractable. This paper does not deal with the optimization of motion planning algorithms, but rather with the simplification of the configuration space ...
Oded Medina   +3 more
doaj   +1 more source

Design of a Novel Long-Reach Cable-Driven Hyper-Redundant Snake-like Manipulator for Inspection and Maintenance

open access: yesApplied Sciences, 2022
Robotic inspection and maintenance are gaining importance due to the number of different scenarios in which robots can operate. The use of robotic systems to accomplish such tasks has deep implications in terms of safety for human workers and can ...
Carlo Canali   +7 more
doaj   +1 more source

Low power consumption mini rotary actuator with SMA wires [PDF]

open access: yes, 2017
Shape memory alloys (SMAs) are smart materials widely used as actuators for their high power to weight ratio despite their well-known low energy efficiency and limited mechanical bandwidth.
Alfred Cuschieri   +9 more
core   +2 more sources

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

open access: yesAdvanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou   +17 more
wiley   +1 more source

基于量子遗传算法的超冗余度机器人逆解优化

open access: yesJixie chuandong, 2013
Hyper redundant robotis such robotwith degreesof freedom far more than itsminimum number of degrees of freedom needed to complete a task.The inverse solution of the hyper-redundant robot is obtained by using the method of backbone curve and the formula ...
赵爽, 李立, 白瑞松
doaj  

Hyper-Redundant Manipulator Capable of Adjusting Its Non-Uniform Curvature with Discrete Stiffness Distribution

open access: yesApplied Sciences, 2022
Hyper-redundant manipulators are widely used in minimally invasive surgery because they can navigate through narrow passages in passive compliance with the human body. Although their stability and dexterity have been significantly improved over the years,
Seongil Kwon   +3 more
doaj   +1 more source

Closed-form position analysis of variable geometry trusses [PDF]

open access: yes, 2017
© . This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/Variable geometry trusses are composed, in general, of unit cells which can be modeled as bars connected by spherical joints.
Porta Pleite, Josep Maria   +1 more
core   +2 more sources

ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment

open access: yesAdvanced Science, EarlyView.
ETV4 coordinates a dual transcriptional program by upregulating MET and asparagine synthetase (ASNS). The resulting asparagine (Asn) secretion acts as a metabolic signal, reprogramming hepatic stellate cells (HSCs) and primary cancer‐associated fibroblasts (CAFs) toward an inflammatory phenotype. These activated stromal cells release HGF to sustain the
Dujiang Fu   +14 more
wiley   +1 more source

Hyper-redundant robot mechanisms and their applications [PDF]

open access: yesProceedings IROS '91:IEEE/RSJ International Workshop on Intelligent Robots and Systems '91, 2002
Hyper-redundant robots have a large or infinite number of degrees of freedom. Such robots are analogous to snakes or tentacles and are useful for operation in highly constrained environments and novel forms of locomotion. The paper reviews newly developed methods for the kinematic analysis of hyper-redundant manipulators.
Chirikjian, Gregory S., Burdick, Joel W.
openaire   +2 more sources

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