Results 1 to 10 of about 44,393 (194)

Ketamine and remote hyperalgesia [PDF]

open access: yesMinerva Anestesiologica, 2018
Porter, Steven B., Schwenk, Eric S.
core   +5 more sources

An improved model of heat-induced hyperalgesia--repetitive phasic heat pain causing primary hyperalgesia to heat and secondary hyperalgesia to pinprick and light touch. [PDF]

open access: yesPLoS ONE, 2014
This study tested a modified experimental model of heat-induced hyperalgesia, which improves the efficacy to induce primary and secondary hyperalgesia and the efficacy-to-safety ratio reducing the risk of tissue damage seen in other heat pain models ...
Tim P Jürgens   +4 more
doaj   +1 more source

Retrograde nerve growth factor signaling modulates tooth mechanical hyperalgesia induced by orthodontic tooth movement via acid-sensing ion channel 3

open access: yesInternational Journal of Oral Science, 2021
Orthodontic tooth movement elicits alveolar bone remodeling and orofacial pain that is manifested by tooth mechanical hyperalgesia. Nerve growth factor (NGF) is upregulated in periodontium and may modulate tooth mechanical hyperalgesia.
Meiya Gao   +11 more
doaj   +1 more source

Neurotrophins and hyperalgesia [PDF]

open access: yesProceedings of the National Academy of Sciences, 1999
Nerve growth factor (NGF), a member of the neurotrophin family, is crucial for survival of nociceptive neurons during development. Recently, it has been shown to play an important role in nociceptive function in adults. NGF is up-regulated after inflammatory injury of the skin.
Lorne M. Mendell, X.-Q. Shu
openaire   +3 more sources

Acidosis Mediates the Switching of Gs-PKA and Gi-PKCε Dependence in Prolonged Hyperalgesia Induced by Inflammation. [PDF]

open access: yesPLoS ONE, 2015
Chronic inflammatory pain, when not effectively treated, is a costly health problem and has a harmful effect on all aspects of health-related quality of life.
Wei-Yu Huang   +3 more
doaj   +1 more source

The connection of monocytes and reactive oxygen species in pain. [PDF]

open access: yesPLoS ONE, 2013
The interplay of specific leukocyte subpopulations, resident cells and proalgesic mediators results in pain in inflammation. Proalgesic mediators like reactive oxygen species (ROS) and downstream products elicit pain by stimulation of transient receptor ...
Dagmar Hackel   +8 more
doaj   +1 more source

Complex interaction of sensory and motor signs and symptoms in chronic CRPS. [PDF]

open access: yes, 2011
Spontaneous pain, hyperalgesia as well as sensory abnormalities, autonomic, trophic, and motor disturbances are key features of Complex Regional Pain Syndrome (CRPS).
Azad, Shahnaz Christina   +7 more
core   +7 more sources

Pain and Cellular Migration Induced by Bothrops jararaca Venom in Mice Selected for an Acute Inflammatory Response: Involvement of Mast Cells

open access: yesFrontiers in Immunology, 2022
Bothrops jararaca venom (BjV) can induce mast cell degranulation. In order to investigate the role of mast cells and the interference of the host genetic background in the inflammation induced by BjV, we have used mouse strains selected for maximal ...
Fernanda V. Kondo   +10 more
doaj   +1 more source

Does naloxone reinstate secondary hyperalgesia in humans after resolution of a burn injury? A placebo-controlled, double-blind, randomized, cross-over study. [PDF]

open access: yesPLoS ONE, 2013
Development of secondary hyperalgesia following a cutaneous injury is a centrally mediated, robust phenomenon. The pathophysiological role of endogenous opioid signalling to the development of hyperalgesia is unclear.
Manuel P Pereira   +5 more
doaj   +1 more source

Home - About - Disclaimer - Privacy