Does naloxone reinstate secondary hyperalgesia in humans after resolution of a burn injury? A placebo-controlled, double-blind, randomized, cross-over study. [PDF]
PLoS ONE, 2013 Development of secondary hyperalgesia following a cutaneous injury is a centrally mediated, robust phenomenon. The pathophysiological role of endogenous opioid signalling to the development of hyperalgesia is unclear.
Manuel P Pereira +5 more
doaj +3 more sources
Interictal widespread pressure hyperalgesia and aura: associations with vestibular migraine in a cross-sectional study [PDF]
Frontiers in NeurologyBackgroundPatients with vestibular migraine (VM) exhibit higher levels of central sensitization and share similar disorder characteristics with migraine with vestibular symptoms (MwVS), except in terms of disability. These patients experience fluctuating
Toshihide Toriyama +2 more
doaj +2 more sources
Progress in Neurobiology, 2014 The importance of the modulation of pain by emotion is now widely recognised. In particular, stress and anxiety, depending on their nature, duration and intensity, can exert potent, but complex, modulatory influences typified by either a reduction or exacerbation of the pain state. Exposure to either acute or chronic stress can increase pain responding
Bright N Okine +2 more
exaly +4 more sources
Obstructive Sleep Apnea and Postoperative Hyperalgesia in Bariatric Surgery: A Prospective Observational Cohort Study [PDF]
Journal of Pain ResearchZhenyu Zhong,1,* Xian Lu,2,* Qian Zhang,1 Yueying Zhang1 1Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of China; 2Department of Shanghai Key Laboratory of Psychotic
Zhong Z, Lu X, Zhang Q, Zhang Y
doaj +2 more sources
An improved model of heat-induced hyperalgesia--repetitive phasic heat pain causing primary hyperalgesia to heat and secondary hyperalgesia to pinprick and light touch. [PDF]
PLoS ONE, 2014 This study tested a modified experimental model of heat-induced hyperalgesia, which improves the efficacy to induce primary and secondary hyperalgesia and the efficacy-to-safety ratio reducing the risk of tissue damage seen in other heat pain models ...
Tim P Jürgens +4 more
doaj +1 more source
International Journal of Oral Science, 2021 Orthodontic tooth movement elicits alveolar bone remodeling and orofacial pain that is manifested by tooth mechanical hyperalgesia. Nerve growth factor (NGF) is upregulated in periodontium and may modulate tooth mechanical hyperalgesia.
Meiya Gao +11 more
doaj +1 more source
Acidosis Mediates the Switching of Gs-PKA and Gi-PKCε Dependence in Prolonged Hyperalgesia Induced by Inflammation. [PDF]
PLoS ONE, 2015 Chronic inflammatory pain, when not effectively treated, is a costly health problem and has a harmful effect on all aspects of health-related quality of life.
Wei-Yu Huang +3 more
doaj +1 more source
The connection of monocytes and reactive oxygen species in pain. [PDF]
PLoS ONE, 2013 The interplay of specific leukocyte subpopulations, resident cells and proalgesic mediators results in pain in inflammation. Proalgesic mediators like reactive oxygen species (ROS) and downstream products elicit pain by stimulation of transient receptor ...
Dagmar Hackel +8 more
doaj +1 more source
Inhibition of DAGLβ as a therapeutic target for pain in sickle cell disease
Haematologica, 2022 Sickle cell disease (SCD) is the most common inherited disease. Pain is a key morbidity of SCD and opioids are the main treatment but their side effects emphasize the need for new analgesic approaches.
Iryna A. Khasabova +10 more
doaj +1 more source
Sex Difference in Oxytocin-Induced Anti-Hyperalgesia at the Spinal Level in Rats with Intraplantar Carrageenan-Induced Inflammation. [PDF]
PLoS ONE, 2016 Previously, we demonstrated intrathecal administration of oxytocin strongly induced anti-hyperalgesia in male rats. By using an oxytocin-receptor antagonist (atosiban), the descending oxytocinergic pathway was found to regulate inflammatory hyperalgesia ...
Lok-Hi Chow +4 more
doaj +1 more source