Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia. [PDF]
, 2013 Repeated water avoidance stress (WAS) induces sustained visceral hyperalgesia (VH) in rats measured as enhanced visceromotor response to colorectal distension (CRD).
Bota, Mihail +6 more
core +14 more sources
An improved model of heat-induced hyperalgesia--repetitive phasic heat pain causing primary hyperalgesia to heat and secondary hyperalgesia to pinprick and light touch. [PDF]
PLoS ONE, 2014 This study tested a modified experimental model of heat-induced hyperalgesia, which improves the efficacy to induce primary and secondary hyperalgesia and the efficacy-to-safety ratio reducing the risk of tissue damage seen in other heat pain models ...
Tim P Jürgens +4 more
doaj +1 more source
International Journal of Oral Science, 2021 Orthodontic tooth movement elicits alveolar bone remodeling and orofacial pain that is manifested by tooth mechanical hyperalgesia. Nerve growth factor (NGF) is upregulated in periodontium and may modulate tooth mechanical hyperalgesia.
Meiya Gao +11 more
doaj +1 more source
Acidosis Mediates the Switching of Gs-PKA and Gi-PKCε Dependence in Prolonged Hyperalgesia Induced by Inflammation. [PDF]
PLoS ONE, 2015 Chronic inflammatory pain, when not effectively treated, is a costly health problem and has a harmful effect on all aspects of health-related quality of life.
Wei-Yu Huang +3 more
doaj +1 more source
The connection of monocytes and reactive oxygen species in pain. [PDF]
PLoS ONE, 2013 The interplay of specific leukocyte subpopulations, resident cells and proalgesic mediators results in pain in inflammation. Proalgesic mediators like reactive oxygen species (ROS) and downstream products elicit pain by stimulation of transient receptor ...
Dagmar Hackel +8 more
doaj +1 more source
Does naloxone reinstate secondary hyperalgesia in humans after resolution of a burn injury? A placebo-controlled, double-blind, randomized, cross-over study. [PDF]
PLoS ONE, 2013 Development of secondary hyperalgesia following a cutaneous injury is a centrally mediated, robust phenomenon. The pathophysiological role of endogenous opioid signalling to the development of hyperalgesia is unclear.
Manuel P Pereira +5 more
doaj +1 more source
Inhibition of DAGLβ as a therapeutic target for pain in sickle cell disease
Haematologica, 2022 Sickle cell disease (SCD) is the most common inherited disease. Pain is a key morbidity of SCD and opioids are the main treatment but their side effects emphasize the need for new analgesic approaches.
Iryna A. Khasabova +10 more
doaj +1 more source
Sex Difference in Oxytocin-Induced Anti-Hyperalgesia at the Spinal Level in Rats with Intraplantar Carrageenan-Induced Inflammation. [PDF]
PLoS ONE, 2016 Previously, we demonstrated intrathecal administration of oxytocin strongly induced anti-hyperalgesia in male rats. By using an oxytocin-receptor antagonist (atosiban), the descending oxytocinergic pathway was found to regulate inflammatory hyperalgesia ...
Lok-Hi Chow +4 more
doaj +1 more source
Secondary hyperalgesia phenotypes exhibit differences in brain activation during noxious stimulation. [PDF]
PLoS ONE, 2015 Noxious stimulation of the skin with either chemical, electrical or heat stimuli leads to the development of primary hyperalgesia at the site of injury, and to secondary hyperalgesia in normal skin surrounding the injury.
Mohammad Sohail Asghar +5 more
doaj +1 more source
Contribution of Piezo2 to endothelium-dependent pain. [PDF]
, 2015 BackgroundWe evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous mechanical stimulus-induced ...
Bogen, Oliver +3 more
core +2 more sources