Progress in Neurobiology, 2014 The importance of the modulation of pain by emotion is now widely recognised. In particular, stress and anxiety, depending on their nature, duration and intensity, can exert potent, but complex, modulatory influences typified by either a reduction or exacerbation of the pain state. Exposure to either acute or chronic stress can increase pain responding
Bright N Okine +2 more
exaly +4 more sources
The effect of psychological manipulations on the development of secondary hyperalgesia: a critical review [PDF]
PAIN Reports. As central sensitization is believed to contribute to persistent pain and psychological factors are increasingly acknowledged to play a role as well, the question arises of whether psychological factors can modulate the development of central ...
Elke Meyers +3 more
doaj +2 more sources
Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors [PDF]
Brazilian Journal of Medical and Biological Research, 2001 The aim of the present study was to determine if phenobarbital affects the nociception threshold. Systemic (1-20 mg/kg) phenobarbital administration dose dependently induced hyperalgesia in the tail-flick, hot-plate and formalin tests in rats and in the ...
C.M. Yokoro +4 more
doaj +2 more sources
Modulating AMPA receptor-dependent synaptic plasticity: Mechanistic interventions against remifentanil-induced hyperalgesia in reoperative rats – A randomised controlled trial [PDF]
Indian Journal of AnaesthesiaBackground and Aims: Intraoperative remifentanil can induce postoperative hyperalgesia. In clinical practice, either unplanned or planned second operations may occur within a short period.
Suqian Guo +4 more
doaj +2 more sources
An improved model of heat-induced hyperalgesia--repetitive phasic heat pain causing primary hyperalgesia to heat and secondary hyperalgesia to pinprick and light touch. [PDF]
PLoS ONE, 2014 This study tested a modified experimental model of heat-induced hyperalgesia, which improves the efficacy to induce primary and secondary hyperalgesia and the efficacy-to-safety ratio reducing the risk of tissue damage seen in other heat pain models ...
Tim P Jürgens +4 more
doaj +1 more source
Neurotrophins and hyperalgesia [PDF]
Proceedings of the National Academy of Sciences, 1999 Nerve growth factor (NGF), a member of the neurotrophin family, is crucial for survival of nociceptive neurons during development. Recently, it has been shown to play an important role in nociceptive function in adults. NGF is up-regulated after inflammatory injury of the skin.
Lorne M. Mendell, X.-Q. Shu
openaire +3 more sources
International Journal of Oral Science, 2021 Orthodontic tooth movement elicits alveolar bone remodeling and orofacial pain that is manifested by tooth mechanical hyperalgesia. Nerve growth factor (NGF) is upregulated in periodontium and may modulate tooth mechanical hyperalgesia.
Meiya Gao +11 more
doaj +1 more source
Evaluation of the Effect of (S)-3,4-Dicarboxyphenylglycine as a Metabotropic Glutamate Receptors Subtype 8 Agonist on Thermal Nociception Following Central Neuropathic Pain [PDF]
Asian Spine Journal, 2021 Study Design In this study, we decided to change the activity of periaqueductal gray (PAG)'s metabotropic glutamate receptors subtype 8 (mGluR8) by means of its specific agonist, (S)-3,4-dicarboxyphenylglycine (DCPG), and by knock downing it with mGluR8 ...
Marjan Hosseini +3 more
doaj +1 more source
Acidosis Mediates the Switching of Gs-PKA and Gi-PKCε Dependence in Prolonged Hyperalgesia Induced by Inflammation. [PDF]
PLoS ONE, 2015 Chronic inflammatory pain, when not effectively treated, is a costly health problem and has a harmful effect on all aspects of health-related quality of life.
Wei-Yu Huang +3 more
doaj +1 more source
The connection of monocytes and reactive oxygen species in pain. [PDF]
PLoS ONE, 2013 The interplay of specific leukocyte subpopulations, resident cells and proalgesic mediators results in pain in inflammation. Proalgesic mediators like reactive oxygen species (ROS) and downstream products elicit pain by stimulation of transient receptor ...
Dagmar Hackel +8 more
doaj +1 more source