Results 91 to 100 of about 104,030 (296)

Rare but relevant: Ibogaine and cardiovascular complications—prolonged QT interval and ventricular arrhythmias

Addiction, EarlyView.
Abstract Revived interest in psychedelic‐assisted therapies has also renewed focus on ibogaine, a psychoactive alkaloid, for its notable anti‐addictive potential. Evidence from observational, open‐label, and limited randomized placebo‐controlled trials indicates that ibogaine and its metabolite noribogaine reduce craving and withdrawal symptoms in ...
Tibor Markus Brunt
wiley   +1 more source

Pain Perception: Investigating Links Between Pain Transmission and CCK(+) Neurons, with Regard to the Opioid Crisis [PDF]

, 2017
With dependence on opioids, such as codeine, morphine, and heroin, steadily increasing amongst the American public, the withdrawal symptoms associated with disuse are receiving much more attention.
Panesar, Sumeet, Tepper, Zachary
core   +2 more sources

Quantitative sensory testing in painful hand osteoarthritis demonstrates features of peripheral sensitisation. [PDF]

, 2012
Hand osteoarthritis (HOA) is a prevalent condition for which treatments are based on analgesia and physical therapies. Our primary objective was to evaluate pain perception in participants with HOA by assessing the characteristics of nodal involvement ...
Ejindu, V, Hermansson, M, Heron, C, Kiely, P, Sofat, N, Wajed, J   +5 more
core   +2 more sources

Opioid‐free vs. opioid‐inclusive anaesthesia with or without regional anaesthesia for postoperative pain: a systematic review with network meta‐analysis of randomised controlled trials

Anaesthesia, EarlyView.
Summary Introduction Concerns about opioid‐related adverse effects have increased interest in opioid‐free anaesthesia, but the benefits compared with opioid‐inclusive techniques, especially in the presence of regional anaesthesia, remain uncertain. Methods We undertook a systematic review with a network meta‐analysis of randomised controlled trials ...
Clístenes C. de Carvalho, Kariem El‐Boghdadly, Idrys H. L. Guedes, Maria Vitória M. Dantas, Danusa P. B. Tomé, Isabella B. Ramos, Clarissa S. H. Gomes, Guilherme K. P. A. Alves, Arthur P. Bezerra, Jayme M. Santos Neto, Jaideep J. Pandit, Leandro G. Braz   +11 more
wiley   +1 more source

Maresin 2, a Specialized Pro-Resolution Lipid Mediator, Reduces Pain and Inflammation Induced by Bothrops jararaca Venom in Mice

Toxins
The venom of Bothrops jararaca (BjV) induces intense and prolonged pain, which is not alleviated by antivenom, along with hemorrhage and inflammation.
Kassyo L. S. Dantas, Beatriz H. S. Bianchini, Matheus D. V. da Silva, Maiara Piva, Joice M. da Cunha, Janaina M. Zanoveli, Fernanda C. Cardoso, Fabiana T. M. C. Vicentini, Camila R. Ferraz, Patricia B. Clissa, Rubia Casagrande, Waldiceu A. Verri   +11 more
doaj   +1 more source

Mispositioned Neurokinin-1 Receptor-Expressing Neurons Underlie Heat Hyperalgesia in Disabled-1 Mutant Mice. [PDF]

, 2019
Reelin (Reln) and Disabled-1 (Dab1) participate in the Reln-signaling pathway and when either is deleted, mutant mice have the same spinally mediated behavioral abnormalities, increased sensitivity to noxious heat and a profound loss in mechanical ...
Basbaum, Allan I, Cilluffo, Marianne, Kim, Ashley S, Phelps, Patricia E, Wang, Xidao, Yvone, Griselda M   +5 more
core  

Metabotropic glutamate receptor 2/3 (mGluR2/3) activation suppresses TRPV1 sensitization in mouse, but not human sensory neurons [PDF]

, 2018
The use of human tissue to validate putative analgesic targets identified in rodents is a promising strategy for improving the historically poor translational record of preclinical pain research.
Baranger, David A.A., Gereau, Robert W, McIlvried, Lisa V, Pullen, Melanie Y, Sheahan, Tayler D, Valtcheva, Manouela V   +5 more
core   +2 more sources

Peripheral and central mechanisms of cutaneous hyperalgesia.

Progress in neurobiology, 1992
Hyperalgesia after cutaneous injury can be divided into two phenomena: Primary hyperalgesia occurs at the site of injury and is characterized by hyperalgesia to mechanical and heat stimuli.
R. Treede, R. Meyer, S. Raja, J. Campbell   +3 more
semanticscholar   +1 more source

TrkA abundance is increased in cutaneous nerves in bortezomib‐induced neuropathy

Brain Pathology, EarlyView.
Cutaneous nerves in bortezomib‐induced peripheral neuropathy (BIPN) show reduced nerve fiber density, increased TrkA expression, and enhanced dermal angiogenesis, highlighting a pathological switch in NGF/TrkA signaling that may contribute to nerve damage and pain. Abstract Tropomyosin receptor kinase A (TrkA), a high‐affinity receptor for nerve growth
Yuying Jin, Nadine Cebulla, Daniel Schirmer, Eva Runau, Leon Flamm, Calvin Terhorst, Laura Jähnel, Johanna Güse, Nicola Giordani, Annett Wieser, Julian Brennecke, Annemarie Sodmann, Martin Kortüm, Robert Blum, Claudia Sommer   +14 more
wiley   +1 more source

In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations

Acta Pharmaceutica, 2018
The aim of this study is to evaluate the antihyperalgesic and antinociceptive effects of two formulations containing peat water extracts using a model of carrageenan-induced hyperalgesia, combined with a test with a mechanical stimulus, and a hot plate ...
Zagorchev Plamen Ivanov, Apostolova Elisaveta Georgieva, Pilicheva Bissera Asenova, Draganova-Filipova Milena Nenkova, Kokova Vesela Yulieva, Lukanov Julian Borisov   +5 more
doaj   +1 more source