Results 91 to 100 of about 100,236 (366)

Contribution of TRPV1 Receptor–Expressing Fibers to Spinal Ventral Root After-Discharges and Mechanical Hyperalgesia in a Spared Nerve Injury (SNI) Rat Model

Journal of Pharmacological Sciences, 2013
Neuropathic pain induces allodynia and hyperalgesia. In the spared nerve injury (SNI) model, marked mechanical hyperalgesia is manifested as prolongation of the duration of paw withdrawal after pin stimulation.
Shohei Yamamoto, Masahiro Ohsawa, Hideki Ono   +2 more
doaj  

The Role of Peripheral N-Methyl-D-Asparate (NMDA) Receptors in Itch and Pain: A Narrative Review. [PDF]

Eur J Pain
ABSTRACT Background and Objective NMDA receptors, predominantly located in the central nervous system and known for their roles in synaptic plasticity and central sensitisation of pain and itch, are also expressed in peripheral sensory neurons. Emerging evidence suggests that peripheral NMDA receptors contribute to pathological pain and potentially ...
Tanaka R, Lo Vecchio S, Aliotta GE, Arendt-Nielsen L.   +3 more
europepmc   +2 more sources

Low-dose buprenorphine infusion to prevent postoperative hyperalgesia in patients undergoing major lung surgery and remifentanil infusion: a double-blind, randomized, active-controlled trial

British Journal of Anaesthesia, 2017
Background Postoperative secondary hyperalgesia arises from central sensitization due to pain pathways facilitation and/or acute opioid exposure. The latter is also known as opioid-induced hyperalgesia (OIH).
M. Mercieri, S. Palmisani, R. D. De Blasi, A. D’andrilli, A. Naccarato, B. Silvestri, S. Tigano, D. Massullo, M. Rocco, R. Arcioni   +9 more
semanticscholar   +1 more source

Uric Acid‐Lowering and Anti‐Hyperuricemia Effects of Plant‐Based Nutraceuticals and Foods: A Review

Food Chemistry International, EarlyView.
Increased UA production and/or decreased UA secretion cause hyperuricemia. Effects and mechanism of flavonoids in reducing UA are summarized. Terpenoids, saponins, alkaloids, vitamin C, polysaccharides, peptides are effective. Plant‐based foods with UA‐lowering ability are reviewed.
Linwei He, Wenjian Yang, Jianhui Liu
wiley   +1 more source

Gabapentin Prevents Oxaliplatin-Induced Mechanical Hyperalgesia in Mice

Journal of Pharmacological Sciences, 2014
.: Oxaliplatin, a platinum-based chemotherapy drug, frequently causes acute and chronic peripheral neuropathies including mechanical hyperalgesia. These adverse effects hinder anticancer therapy with the drug.
Masahiro Ohsawa, Saki Otake, Tomoyasu Murakami, Shohei Yamamoto, Toshiaki Makino, Hideki Ono   +5 more
doaj  

A literature review on the pharmacological sensitivity of human evoked hyperalgesia pain models.

British Journal of Clinical Pharmacology, 2016
AIMS Human evoked pain models can be used to determine the efficacy of new and existing analgesics and to aid in the identification of new targets.
Guido van Amerongen, Matthijs W de Boer, G. Groeneveld, J. Hay   +3 more
semanticscholar   +1 more source

Hyperalgesia in semantic dementia [PDF]

Arquivos de Neuro-Psiquiatria, 2011
There are very few studies addressing pain mechanisms in frontotemporal lobar degeneration (FTLD), as well as the possible contributions that the study of the neurobiological basis of pain in dementia can confer to the knowledge of general pain physiopathology itself1,2.
Caixeta, Leonardo, Soares, Vânia Lúcia Dias, Soares, Cândida D.   +2 more
openaire   +4 more sources

Genetically‐targeted control of the spinal cord and peripheral nervous system

Journal of Intelligent Medicine, EarlyView.
Application of genetically‐targeted stimulation for treating diseases or injuries outside the brain. Optogenetic and chemogenetic systems have been developed for dysfunction in the cochlea, spinal cord, dorsal root ganglia (DRGs), peripheral nerves, lower urinary tract, and enteric nervous system (ENS). Created with Biorender.com.
Anakaren Romero Lozano, Victoria Koptelova, Zoya Ahmad, Huiliang (Evan) Wang   +3 more
wiley   +1 more source

Heat pain detection threshold is associated with the area of secondary hyperalgesia following brief thermal sensitization: a study of healthy male volunteers

Journal of Pain Research, 2017
Morten Sejer Hansen,1 Jørn Wetterslev,2 Christian Bressen Pipper,3 Mohammad Sohail Asghar,1 Jørgen Berg Dahl4 1Department of Anesthesiology, 4231, Centre of Head and Orthopedics, Rigshospitalet, 2Copenhagen Trial Unit, Centre for Clinical ...
Hansen MS, Wetterslev J, Pipper CB, Asghar MS, Dahl JB   +4 more
doaj  

The Involvement of Endothelin Pathway in Chronic Psychological Stress-Induced Bladder Hyperalgesia Through Capsaicin-Sensitive C-Fiber Afferents

Journal of Inflammation Research, 2022
Chuying Qin,1 Yinhuai Wang,1 Sai Li,2 Yuanyuan Tang,3 Yunliang Gao1 1Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, 410011, People’s Republic of China; 2Acupuncture and Tuina School, Hunan University of Chinese ...
Qin C, Wang Y, Li S, Tang Y, Gao Y
doaj