Results 91 to 100 of about 84,168 (327)

GRK6, a gatekeeper of visceral hyperalgesia

Brain, Behavior, and Immunity, 2009
Brief ...
Murga, Cristina, Mayor Menéndez, Federico   +1 more
openaire   +3 more sources

Intravenous methadone for pain management in cardiac surgery: a randomised controlled trial with plasma concentration analysis*

Anaesthesia, EarlyView.
Summary Introduction Postoperative pain after cardiac surgery remains significant despite the administration of opioids. Methadone may improve pain control and decrease the need for postoperative opioids. Randomised controlled trials, however, are limited and the effects of cardiopulmonary bypass on methadone pharmacokinetics are unclear.
Henry Man Kin Wong, Veronica Ka Wai Lai, Sandra Lok Ching Chiu, Wai Tat Wong, Siu Kwan Wo, Joan Zhong Zuo, Xiaodong Liu, Randolph Hung Leung Wong, Kwok Ming Ho   +8 more
wiley   +1 more source

Neuroinflammation, Mast Cells, and Glia: Dangerous Liaisons [PDF]

, 2017
The perspective of neuroinflammation as an epiphenomenon following neuron damage is being replaced by the awareness of glia and their importance in neural functions and disorders.
Alhouayek M, Amor S, Amor S, Appel SH, Bankston AN, Biber K, Biran V, Borsook D, Brenner T, Brooks TA, Buchanan MM, Bulanova E, Burnstock G, Calcia MA, Castellheim A, Chan-Ling T, Chen YJ, Choudhuri K, Christophi GP, Christy AL, Compston A, Conti P, Corrigan F, Cristino L, Cunningham C, Dirckx M, Donath MY, Done JD, D’Agostino G, Eckenhoff RG, Eggen BJ, Ellis A, Engler H, Ertürk A, Eskander MA, Esposito P, Fonken LK, Forsythe P, Freeman LC, Fullerton JN, Gao YJ, Gaudenzio N, Geppetti P, Grace PM, Grakoui A, Gregory GD, Griffin RS, Guerreiro R, Gunin AG, Hagiyama M, Hains LE, Hanisch UK, Harcha PA, Harvey GK, Hayashi R, Heneka MT, Hickman SE, Hsieh CL, Hu W, Héron A, Iadecola C, Ito A, Jay GW, Jensen TS, Ji RR, Jin Y, Jin Y, Juremalm M, Kajihara Y, Kalesnikoff J, Kalichman MW, Kamm CP, Kerstman E, Kobayashi K, Kolbinger F, Koshinaga M, Kwon C, Lange C, Lapilover EG, Laura Facci, Le Thuc O, Leon A, Levy D, Li M, Li X, Liew FY, Lozada A, Lull ME, Luongo L, Manocha GD, Marchi N, Martini R, Maslinska D, Mate I, Matsuda H, Mattila OS, McGeer PL, Medeiros R, Medic N, Medic N, Michaloudi H, Michaud M, Millan MJ, Miller G, Milligan ED, Monks CR, Morena Zusso, Myers RR, Nakae S, Nakajima A, Nathan C, Nave KA, Nelissen S, Nguyen M, Norden DM, Noriega DB, Old EA, Orr AG, Osipchuk Y, Osterberg A, Park CK, Parvathenani LK, Patti GJ, Peferoen L, Peferoen LA, Pekny M, Pelisch N, Perry VH, Perry VH, Pietro Giusti, Prinz M, Prussin C, Punzo D, Ramlackhansingh AF, Ransohoff RM, Rapp JH, Rawji KS, Riedel B, Rivat C, Rosa AC, Sakamoto A, Sastre M, Sayed BA, Silver R, Silverman AJ, Sivanandam TM, Skaper SD, Skaper SD, Skaper SD, Skaper SD, Skaper SD, Skuljec J, Smith BH, Smith JA, Sospedra M, Stephen D. Skaper, Streit WJ, Suurmond J, Terrando N, Thacker MA, Theoharides TC, Theoharides TC, Theoharides TC, Theoharides TC, Theoharides TC, Ulmann L, van Hecke O, Varma R, von Büdingen HC, Vyas H, Wang M, Wang Y, Wardlaw AJ, Watkins LR, Wohleb ES, Xie F, Young KM, Yuan H, Zarpelon AC, Zeis T, Zhang H, Zhang S, Zhang ZG, Zuo Y   +183 more
core   +1 more source

Postoperative sore throat: a systematic review*

Anaesthesia, EarlyView.
Summary Introduction Postoperative sore throat is a common complaint with an incidence of up to 62%. While anaesthetists often perceive this as a minor and self‐limiting complication, postoperative sore throat is one of the leading causes of postoperative anaesthesia‐related discomfort.
Zachary J. Moulder, Jason Mann, Paul Bramley, Jana Heinz, Matthew D. Wiles   +4 more
wiley   +1 more source

Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat

Cell Reports, 2016
The naked mole-rat is a subterranean rodent lacking several pain behaviors found in humans, rats, and mice. For example, nerve growth factor (NGF), an important mediator of pain sensitization, fails to produce thermal hyperalgesia in naked mole-rats. The
Damir Omerbašić, Ewan St. J. Smith, Mirko Moroni, Johanna Homfeld, Ole Eigenbrod, Nigel C. Bennett, Jane Reznick, Chris G. Faulkes, Matthias Selbach, Gary R. Lewin   +9 more
doaj   +1 more source

Tramadol Induced Paradoxical Hyperalgesia

Pain Physician, 2013
Opioids have been the mainstay analgesics for postoperative, cancerous, and chronic noncancerous pain. Common concerns regarding the use of opioids include the development of physical dependence and addiction. However, as a potential complication of opioid therapy, opioid-induced hyperalgesia (OIH) is often overlooked.
Seong Heon Lee, Woong Mo Kim, Hyung Gon Lee, Myung Ha Yoon, Jeong Il Choi, Soo Young Cho   +5 more
openaire   +3 more sources

Pain Perception: Investigating Links Between Pain Transmission and CCK(+) Neurons, with Regard to the Opioid Crisis [PDF]

, 2017
With dependence on opioids, such as codeine, morphine, and heroin, steadily increasing amongst the American public, the withdrawal symptoms associated with disuse are receiving much more attention.
Panesar, Sumeet, Tepper, Zachary
core   +2 more sources

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

Does Electroacupuncture Have Different Effects on Peripheral and Central Sensitization in Humans: A Randomized Controlled Study

Frontiers in Integrative Neuroscience, 2019
BackgroundAcupuncture is used to reduce chronic musculoskeletal pain. The common mechanism underlying these types of pain are peripheral and/or central sensitization.
Zhen Zheng, Linghan Bai, Meredith O’Loughlan, Chun Guang Li, Charlie C. Xue   +4 more
doaj   +1 more source

Opioid-Induced Hyperalgesia (OIH)

Brazilian Journal of Anesthesiology, 2010
Opioids are commonly used for pain control; however, they can cause hyperalgesia. The reason why this can happen is not known. The objective of this review was to describe the mechanisms, factors implicated, and drug modulation.The factors implicated in the development of opioid-induced hyperalgesia (OIH), such as duration of use, dose, and type of ...
Plinio da Cunha Leal, Jefferson Clivatti, João Batista Santos Garcia, Rioko Kimiko Sakata   +3 more
openaire   +3 more sources