Results 121 to 130 of about 85,056 (307)

Evaluation of behavior in transgenic mouse models to understand human congenital pain conditions [PDF]

, 2018
BACKGROUND: Containing a brain for signal processing and decision making, and a peripheral component for sensation and response, the nervous system provides higher organisms a powerful method of interacting with their environment.
Bullock, Daniel
core  

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

Application of the augmented competing stimulus assessment to identify and establish competing self‐restraint items

Journal of Applied Behavior Analysis, Volume 59, Issue 1, Winter 2026.
Abstract Automatically maintained self‐injurious behavior (SIB) sometimes co‐occurs with self‐restraint, a self‐limiting behavior that impedes SIB and can be maladaptive (e.g., hinders functional skills and movement). The presence of self‐restraint suggests SIB produces aversive consequences, which self‐restraint limits.
Michelle A. Frank‐Crawford, Louis P. Hagopian, Jonathan D. Schmidt, Griffin W. Rooker, Drew E. Piersma, Ryan Benson   +5 more
wiley   +1 more source

Dim Light at Night Exposure Induces Cold Hyperalgesia and Mechanical Allodynia in Male Mice

, 2020
Jacob R. Bumgarner, William H. Walker, Jennifer A. Liu, James C. Walton, Randy J. Nelson   +4 more
openalex   +2 more sources

Interictal widespread pressure hyperalgesia and aura: associations with vestibular migraine in a cross-sectional study

Frontiers in Neurology
BackgroundPatients with vestibular migraine (VM) exhibit higher levels of central sensitization and share similar disorder characteristics with migraine with vestibular symptoms (MwVS), except in terms of disability. These patients experience fluctuating
Toshihide Toriyama, Yoshiki Hanaoka, Tetsuyoshi Horiuchi   +2 more
doaj   +1 more source

Use of Continuous Regional Anesthesia Infusion as an Opioid‐Sparing Modality in Mechanically Ventilated Patients With Acute Traumatic Rib Fractures—A Retrospective Study

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 1, January 2026.
ABSTRACT Background Continuous regional anesthesia (CRA) techniques are used for analgesia in patients with acute rib fractures. However, there is a paucity of evidence supporting the initiation of CRA in patients receiving mechanical ventilation (MV). We therefore performed this retrospective study to assess changes in opioid consumption and the rate ...
Howard Meng, Ahtsham U. Niazi, Lan Zhou, Naheed Jivraj, Lavarnan Sivanathan, Stephen Choi   +5 more
wiley   +1 more source

Intrathecal administration of Ca_v3.2 and Ca_v3.3 antisense oligonucleotide reverses tactile allodynia and thermal hyperalgesia in rats following chronic compression of dorsal root of ganglion [PDF]

, 2006
Xianjie Wen, Zhang-jun LI, Zhi‐Xin Chen, Zhiyuan Fang, Yang Chenxiang, Heng Li, Zeng Yin-ming   +6 more
openalex   +1 more source

The Potential Role of Glycogen Synthase Kinase-3β in Neuropathy-Induced Apoptosis in Spinal Cord

Basic and Clinical Neuroscience, 2020
Introduction: Glycogen Synthase Kinase-3β (GSK-3β) participates in several signaling pathways and plays a crucial role in neurodegenerative diseases, inflammation, and neuropathic pain. The ratio of phosphorylated GSK-3β over total GSK-3β (p-GSK-3β/t-GSK-
Mina Rashvand, Samira Danyali, Homa Manaheji   +2 more
doaj  

Opioid Consumption After Laparoscopic Radical Nephrectomy in Early Postoperative Recovery Phase: A Retrospective Cohort Study

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 1, January 2026.
ABSTRACT Background Laparoscopic radical nephrectomy is a relatively common surgical procedure in the treatment of renal cancer and kidney anomalies. Postoperative pain is a major challenge among these patients. Although alternate solutions to conduct analgesia have been researched lately, the pain management of nephrectomy patients still relies on ...
Karla Lilleberg, Merja Vakkala, Vesa Kontinen, Sanna Kakko, Janne Liisanantti, Juho Nurkkala   +5 more
wiley   +1 more source

Evoked Human Oesophageal Hyperalgesia: A Potential Tool for Analgesic Evaluation? [PDF]

, 2009
Anne Estrup Olesen, Camilla Staahl, Christina Brock, Lars Arendt‐Nielsen, Asbjørn Mohr Drewes   +4 more
openalex   +1 more source