Results 171 to 180 of about 86,101 (292)

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei, Mingyue Liuyuan, Zhixin Ye, Xueying Wang, Xueli Zhou, Yifan Shan, Cheng He, Chunting Zhu, Chicheng Zhou, Jingyin Bao, Yonghui Zhang, Gang Chen   +11 more
wiley   +1 more source

Visceral Hyperalgesia Induced by Forebrain-Specific Suppression of Native Kv7/KCNQ/M-Current in Mice

, 2011
Yuxiao Bi, Hui Chen, Jun Su, Xu Cao, Xiling Bian, KeWei Wang   +5 more
openalex   +1 more source

Response to High‐Dose Topical Capsaicin in Neuropathic Pain: Absence of Deep Pain as a Predictor of Analgesic Effect

European Journal of Pain, Volume 30, Issue 1, January 2026.
ABSTRACT Background Topical high‐dose capsaicin treatment is a recommended therapy for localised neuropathic pain with good tolerability and no identified drug interactions. However, it is not effective for every patient. So far, few parameters in patient history have been identified as predictors for response to capsaicin treatment.
Manon Sendel, Lena Ehmke, Andreas Dunst, Jan Vollert, Henrike Bruckmüller, Sandra Brügge, Stefanie Rehm, Janne Gierthmühlen, Dilara Kersebaum, Ingolf Cascorbi, Ralf Baron, Julia Forstenpointner   +11 more
wiley   +1 more source

Effects of esketamine on postoperative pain, anxiety, depression, sleep, and inflammation in pregnancies undergoing cesarean section: A randomized controlled trial. [PDF]

PLoS One
Wang Y, Lin X, Zou X, Zhang R, Xing J, Zhang L, Shen J, Zhang X, Zhou D, Zhang J.   +9 more
europepmc   +1 more source

Patient‐Reported Symptom and Symptom Clusters During Immune Checkpoint Inhibitor Therapy for Cancer Patients: A Cross‐Sectional Survey

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims Cancer treatment management necessitates comprehensive symptom burden assessment, particularly with therapies like immune checkpoint inhibitors (ICIs), known for unique toxicities. While ICIs show promising outcomes, they also induce immune‐related adverse events (irAEs), posing challenges due to their varied onset ...
Simeng Ren, Jingqi Yang, Hongkun Xu, Jiayue Jin, Shuo Wang, Baojin Han, Wenzheng Zhang, Yutong Lv, Jie Liu   +8 more
wiley   +1 more source

Antinociceptive and anti-inflammatory effects of a formulation based on <i>Alpinia zerumbet</i> essential oil: an <i>in vivo</i> and <i>in vitro</i> approach. [PDF]

J Oral Facial Pain Headache
Hummig W, Zortea JM, Dos Santos VAB, Ferreira LEN, Chichorro JG.   +4 more
europepmc   +1 more source

Diagnostic and Therapeutic Potential of Substance P/NK1 Receptor in Primary Dysmenorrhea: A Pilot Study

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims Primary dysmenorrhea is a prevalent condition that causes significant menstrual pain and discomfort, impacting many women′s daily activities. The Substance P/NK1 receptor (SP/NK1R) pathway has been linked to the pain mechanisms underlying dysmenorrhea, yet its potential as a therapeutic target remains inadequately explored.
Riffat Mehboob, Imran Shahid, Abdullah R. Alzahrani, Shimaa Mohammad Yousof, Hafsa Adnan, Samar N. Ekram, Ahmad Alwazzan, Hisham Nasief, Khalid A. Khadawardi   +8 more
wiley   +1 more source

Hydrogen-Rich Water Potentiates Cannabinoid- and Gabapentinoid-Induced Analgesia in Neuropathic Pain. [PDF]

Int J Mol Sci
Tort NA, Negrini-Ferrari SE, Pol O.
europepmc   +1 more source

Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome

Zhengyang Li, Yuqing Mao, Qian Hua, Yonghong Sun, Haiyan Wang, Xuan-Guang Ye, Jing-Xian Hu, Yajie Wang, Miao Jiang   +8 more
openalex   +1 more source

Characterization of nociceptin-induced allodynia and hyperalgesia

, 1998
Toshiaki Minami, Emiko Okuda‐Ashitaka, Hidemaro Mori, Kenji Sakimura, Masayoshi Mishina, Seiji Ito   +5 more
openalex   +1 more source