Results 91 to 100 of about 4,383 (214)

Antimicrobial, Anti‐Biofilm Activity and Antioxidants of Phenolic Compounds Isolated From Hypericum perforatum on Periodontal Pathogenic Oral Bacteria

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
The study on Hypericum perforatum revealed its leaf fractions possess potent antimicrobial and antioxidant properties against periodontal bacteria, specifically Eikenella corrodens and Morococcus cerebrosus. Fraction I exhibited the highest antimicrobial activity, with significant inhibition zones, and effectively reduced biofilm formation ...
Siba Mouid Al‐haliem, Muthanna Jasim Mohammed, Mohammad Ali Hesarinejad, Tarek Gamal Abedelmaksoud   +3 more
wiley   +1 more source

Acid Sphingomyelinase Impacts Canonical Transient Receptor Potential Channels 6 (TRPC6) Activity in Primary Neuronal Systems

Cells, 2020
The acid sphingomyelinase (ASM)/ceramide system exhibits a crucial role in the pathology of major depressive disorder (MDD). ASM hydrolyzes the abundant membrane lipid sphingomyelin to ceramide that regulates the clustering of membrane proteins via ...
Stefanie Zeitler, Fabian Schumacher, Juliana Monti, Daniela Anni, Debarpan Guhathakurta, Burkhard Kleuser, Kristina Friedland, Anna Fejtová, Johannes Kornhuber, Cosima Rhein   +9 more
doaj   +1 more source

Johanniskraut - von Inhaltsstoffen und anderen Unwägbarkeiten [PDF]

, 2009
Die Depression gehört zu den häufigsten Volkskrankheiten. Derzeit sind rund vier Millionen Deutsche an einer behandlungsbedürftigen Depression erkrankt.
Schubert-Zsilavecz, Manfred (Prof. Dr.), Wurglics, Mario   +1 more
core  

Micropropagation for the production of high quality phytochemicals [PDF]

, 2013
Plants area source of many valuable secondary metabolites that find a broad field of applications, ranging from the agrochemical to the pharmaceutical industries.
Grevenstuk, Tomás, Romano, Anabela
core   +1 more source

Secondary metabolites of medicinal use in Hypericum spp.: a rich history and a promising future

Medicinal Plant Biology
The genus Hypericum, which comprises over 450 species worldwide, has a long history of use in traditional medicine. It is now known for its antidepressant, antiviral, antibacterial, and anticancer properties.
Stefania Poulaki, Konstantinos Vlachonasios   +1 more
doaj   +1 more source

Hypericum perforatum cultures as a tool to study plant defence mechanisms against anthracnose (colletotrichum gloeosporioides) [PDF]

, 2006
To elucidate the defence mechanisms of Hypericum perforatum L. against Colletotrichum gloeosporioides, we utilized cell suspension cultures. When primed with methyl jasmonate, H.
Conceição, Luís F. R., Dias, Alberto Carlos Pires, Franklin, Gregory, Ribeiro, Catarina   +3 more
core  

Hypericum empetrifolium and H. lydium as Health Promoting Nutraceuticals: Assessing Their Role Combining In Vitro In Silico and Chemical Approaches

Food Science &Nutrition, Volume 13, Issue 4, April 2025.
The Hypericum can be considered a good vegetal source for the preparation of nutraceuticals and food supplements useful as health‐promoting products against oxidative stress‐related diseases such as diabetes, cancer, and Alzheimer's disease. ABSTRACT Hypericum species are known for their ability to produce multiple classes of secondary metabolite and ...
Stefania Sut, Stefano Dall'Acqua, Giancarlo Angeles Flores, Gaia Cusumano, İsmail Koyuncu, Ozgur Yuksekdag, Carla Emiliani, Roberto Venanzoni, Paola Angelini, Selami Selvi, Evren Yildiztugay, Adriano Mollica, Eleonora Procino, Gregorio Peron, Lorenza Marinaccio, Gokhan Zengin   +15 more
wiley   +1 more source

BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly [PDF]

, 2016
The pro-inflammatory leukotrienes (LTs) are formed from arachidonic acid (AA) in activated leukocytes, where 5-lipoxygenase (5-LO) translocates to the nuclear envelope to assemble a functional complex with the integral nuclear membrane protein 5-LO ...
Banoglu, Erden, Emini, Besa, Garscha, Ulrike, Gerstmeier, Jana, Liening, Stefanie, PACE, SIMONA, ROSSI, ANTONIETTA, Rummler, Silke, SAUTEBIN, LIDIA, Schubert, Ulrich S, Scriba, Gerhard K. E, Voelker, Susanna, Weinigel, Christina, Werz, Oliver, Çalışkan, Burcu, Çelikoğlu, Erşan   +15 more
core   +1 more source

Nuclear receptors in vascular biology [PDF]

, 2015
Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics.
A Chawla, A McCurley, AA Hamers, AL Bookout, B Fisslthaler, BG Hoebel, C McCarthy, C Zhou, CH Lee, CK Glass, CK Huang, CT Lee, D Bishop-Bailey, D Bishop-Bailey, David Bishop-Bailey, DP Edwards, E Gerlach, F Akbiyik, FA Pereira, FL Wynne, FY Ali, G Pascual, I Dussault, I Spoletini, J He, J Qin, J Sonoda, J Xiang, K Spruiell, KE Swales, L Calza, L Li, L Piqueras, LA Moraes, LA Moraes, LJ Jonk, LR You, M Kaushik, M Matic, N Albermann, N Schafer, N Takamoto, Q Qin, R Zhao, S Asgary, S Chakrabarti, S Marino De, S Stein, SA Kliewer, V Zoete, W El-Sankary, WC Lau, X Wang, Y Ma, Y Sui, Y Sui, YW Hu   +56 more
core   +3 more sources

Tissue Regeneration and Remodeling in Rat Models after Application of Hypericum perforatum L. Extract-Loaded Bigels

Gels
The wound-healing effect of St. John’s Wort (SJW) is mainly attributed to hyperforin (HP), but its low stability restricts its topical administration. This study investigates how “free” HP-rich SJW extract (incorporated into a bigel; B/SJW) and extract ...
Yoana Sotirova, Yoana Kiselova-Kaneva, Deyana Vankova, Oskan Tasinov, Diana Ivanova, Hristo Popov, Minka Hristova, Krastena Nikolova, Velichka Andonova   +8 more
doaj   +1 more source