Results 71 to 80 of about 4,383 (214)

In Vitro, In Vivo, and Clinical Trial Approaches to Investigate the Effects of Medicinal Plants on Burn Wound Healing: A Systematic Review

International Wound Journal, Volume 22, Issue 11, November 2025.
ABSTRACT Use of synthetic drugs for the treatment of burn wounds has decreased due to adverse effects, and they are gradually being replaced by compounds obtained from natural products, especially medicinal plants. This review focused on pre‐clinical and clinical studies examining the efficacy of medicinal plants in promoting burn wound healing.
Mahdi Bagheri, Seyed Mohammad Zarei, Mostafa Soodmand, Hossein Mardani Nafchi, Mir Hossein Hashemi Poor   +4 more
wiley   +1 more source

TRPC6-mediated ERK1/2 Activation Regulates Neuronal Excitability via Subcellular Kv4.3 Localization in the Rat Hippocampus

Frontiers in Cellular Neuroscience, 2017
Recently, we have reported that transient receptor potential channel-6 (TRPC6) plays an important role in the regulation of neuronal excitability and synchronization of spiking activity in the dentate granule cells (DGC).
Ji-Eun Kim, Jin-Young Park, Tae-Cheon Kang   +2 more
doaj   +1 more source

Hyperforin promotes mitochondrial function and development of oligodendrocytes [PDF]

Journal of Neurochemistry, 2011
J. Neurochem.(2011)119, 555–568.AbstractSt. John’s wort has been found to be an effective and safe herbal treatment for depression in several clinical trials. However, the underlying mechanism of its therapeutic effects is unclear. Recent studies show that the loss and malfunction of oligodendrocytes are closely related to the neuropathological changes
Yanlin, Wang, Yanbo, Zhang, Jue, He, Handi, Zhang, Lan, Xiao, Adil, Nazarali, Zhijun, Zhang, Dai, Zhang, Qingrong, Tan, Jiming, Kong, Xin-Min, Li   +10 more
openaire   +2 more sources

Fabrication of Multifunctional Nanofiber Mats by Emulsion Electrospinning of TPU/Fish Skin Gelatin Incorporating Plant Extract‐Based Therapeutic Oil for Wound Dressing Applications

Macromolecular Materials and Engineering, Volume 310, Issue 10, October 2025.
This study not only combines TPU with fish skin gelatin (FSG) and H. perforatum oil (HPO) through emulsion electrospinning for the first time, but also reduces the TPU fiber diameter, which is crucial for enhancing wound healing. Overall results indicate that this combination can enhance wound healing and antimicrobial efficancy, making the resulting ...
Rüya Keskinkaya, Arzu Yıldırım, Şeyma Çağlayan, Eray Sarper Erdoğan, Yurdanur Türker, Dilara Nur Dikmetaş, Funda Karbancıoğlu ‐ Güler, Saime Batirel, Fatma Seniha Güner, Melek Erol‐Taygun   +9 more
wiley   +1 more source

Improvement of Hypericin and Hyperforin Production Using Zinc and Iron Nano-oxides as Elicitors in Cell‏ Suspension Culture of St John's wort (Hypericum perforatum L.) [PDF]

Journal of Medicinal Plants and By-products, 2013
Zinc and iron nano-oxides (100 ppb) were promoted the hypericin and hyperforin production in Hypericum perforatum cell suspension culture. High performance liquid chromatography method was used for detectection and identification of hypericin and ...
doaj  

An Unusual Michael-Induced Skeletal Rearrangement of a Bicyclo[3.3.1]nonane Framework of Phloroglucinols to a Novel Bioactive Bicyclo[3.3.0]octane [PDF]

, 2013
A novel skeletal rearrangement of bicyclo[3.3.1]nonane-2,4,9-trione (16) to an unprecedented highly functionalized bicyclo[3.3.0]octane system (17), induced by an intramolecular Michael addition, is presented.
Christou, Yiota A., Couladouros, Elias A., Dakanali, Marianna, Demadis, Konstantinos D., Mitsopoulou, Kornilia P., Odysseos, Andreani D., Vidali, Veroniki P.   +6 more
core   +1 more source

New Insights into Secondary Metabolite Potential in Hypericum Perforatum, UPLC‐ESI‐MS/MS to Novel Phytochemical Discovery with Bioactivity Assessment

ChemistrySelect, Volume 10, Issue 40, October 27, 2025.
Investigation of bioactive components in Hypericum Perforatum. Abstract Different anatomical components of Hypericum perforatum (H. perforatum) have been utilized by humans for generations as a natural remedy with pharmacological attributes. This work aimed to investigate the secondary metabolite potential of H.
Labza Roumaissa, Hamida Saida Cherif, Larbi Derbak, Petras Rimantas Venskutonis, Ibrahim Demirtas, Alzahrani Mohammed M, Fehmi Boufahja, Hamdi Bendif, Stefania Garzoli   +8 more
wiley   +1 more source

Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes

Frontiers in Physiology, 2018
Background and Purpose: Store-operated calcium entry (SOCE) is an important physiological phenomenon that extensively mediates intracellular calcium ion (Ca2+) load. It has been previously found in myocytes isolated from neonatal or diseased hearts.
Hairuo Wen, Hairuo Wen, Zhenghang Zhao, Nadezhda Fefelova, Lai-Hua Xie   +4 more
doaj   +1 more source

The antidepressant effect of hypericum perforatum extract Ze 117 is associated with reduced possibilities of drug interactions than hypericum perforatum extract LI 160. [PDF]

, 2013
Hypericum perforatum (HP) is the most extensively investigated medicinal herbs with antidepressant effect. Differences showed by HP extracts in their antidepressant effect and their clinical consequence of HP-drug interactions have been related with HP ...
Bellido, M Victoria, Bellido-Estevez, Inmaculada, Blanco-Reina, Encarnacion, Cabello-Porras, Maria Rosario, Gómez-Luque, A., Marquez, Elisa Isabel   +5 more
core  

Myrtucommulone from Myrtus communis: metabolism, permeability, and systemic exposure in rats [PDF]

, 2012
Nonsteroidal anti-inflammatory drug intake is associated with a high prevalence of gastrointestinal side effects, and severe cardiovascular adverse reactions challenged the initial enthusiasm in cyclooxygenase-2 inhibitors.
Abdel-Tawab M, Barrett JS, Gerbeth K, Hüsch J, Meins J, Rossi A, Sautebin L, Schubert-Zsilavecz M, Skarke C, Werz O, Wiechmann K   +10 more
core   +1 more source