Results 71 to 80 of about 2,864 (178)
No clinically relevant CYP3A induction after St. John’s wort with low hyperforin content in healthy volunteers [PDF]
, 2009 Objective Induction of CYP3A by St. John’s wort (SJW) products with high hyperforin content is well described. Since CYP3A induction is mediated by hyperforin in a concentration-dependent manner, and SJW preparations differ significantly in hyperforin ...
Frank, B +10 more
core +1 more source
St. John\'s wort (Hypericum perforatum L.): A Review
Journal of Medicinal Plants, 2005 Hypericum perforatum L., also known St. John's wort, is a herbaceous perennial belonging to Hypericaceae family that is a native of Western Europe, North Africa, and Asia. The importance of this plant as a phytopharmaceutical, especially for treatment of
H Naghdi Badi +3 more
doaj
Cosmetics, 2015 Organisms produce free radicals which are essential for various metabolic processes (enzymatic oxidation, cellular respiration, signaling). Antioxidants are important chemical compounds that specifically prevent the oxidation of substances by scavenging ...
Silke Barbara Lohan +13 more
doaj +1 more source
Hyperforin promotes mitochondrial function and development of oligodendrocytes [PDF]
, 2009 Major depressive disorder is a common severe psychiatric disorder with unknown etiology. Recent studies show that the loss and malfunction of oligodendrocytes are closely related to the neuropathological changes in depression, which can be reversed by ...
Wang, Yanlin
core
, 2018 ObjectiveThe aim of this study was to review herb–drug interaction studies with St John's wort (Hypericum perforatum L.) with a focus on the hyperforin content of the extracts used in these studies.MethodsPUBMED was systematically searched to identify ...
Julia Vlachojannis +5 more
core +1 more source
Enantioselective Total Synthesis of Hyperforin
, 2016 A modular, 18-step total synthesis of hyperforin is described. The natural product was quickly accessed using latent symmetry elements, whereby a group-selective, Lewis acid-catalyzed epoxide-opening cascade cyclization was used to furnish the bicyclo[3 ...
David C. Moebius (1667218) +2 more
core +1 more source
Secondary Metabolites of and their Possible Chemotaxonomic Significance
Natural Product Communications, 2010 The phloroglucinol derivative hyperforin, the naphthodianthrones hypericin and pseudohypericin, the phenylpropane chlorogenic acid, and the flavonoids rutin, hyperoside, apigenin-7- O -glucoside, kaempferol, quercitrin, quercetin and amentoflavone were ...
Cüneyt Çırak +3 more
doaj +1 more source
, 2010 International audienceCortical neurons embryos (E13) from murine brain have a wide diversity of plasma membrane Ca(2+)-conducting channels. For instance, they express several types of transient receptor potential channels of C-type (TRPC) and hyperforin,
Gibon, Julien +5 more
core +1 more source
Hyperforin analogues from St. John's wort (Hypericum perforatum)
, 2000 Three oxygenated analogues of the prenylated phloroglucinol hyperforin (3-5) were isolated from the aerial parts of Hypericum perforatum and their structures elucidated by spectroscopic ...
VEROTTA L. +7 more
core +1 more source
Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.
, 2009 We previously showed that, in vitro, hyperforin from St. John’s wort (Hypericum perforatum ) inhibits 5-lipoxygenase (5-LO), the key enzyme in leukotriene biosynthesis.
O. WERZ +14 more
core +1 more source