Results 61 to 70 of about 2,864 (178)

Bioactive compounds from Hypericum humifusum and Hypericum perfoliatum: inhibition potential of polyphenols with acetylcholinesterase and key enzymes linked to type-2 diabetes

Pharmaceutical Biology, 2017
Context: Natural products are reported to have a wide spectrum of pharmacological properties such as antimicrobial, anti-inflammatory and anti-cholinesterase.
Afef Béjaoui, Issam Ben Salem, Nesrine Rokbeni, Yassine M’rabet, Mohamed Boussaid, Abdennacer Boulila   +5 more
doaj   +1 more source

Chemical structure of hyperforin and its derivatives.

, 2013
Chemical structure of hyperforin and its derivatives.
Luisella Verotta (366388), Ana R. Quesada (210718), Miguel Ángel Medina (366390), Beatriz Martínez-Poveda (286524), Ezio Bombardelli (366389)   +4 more
core   +1 more source

Tissue Regeneration and Remodeling in Rat Models after Application of Hypericum perforatum L. Extract-Loaded Bigels

Gels
The wound-healing effect of St. John’s Wort (SJW) is mainly attributed to hyperforin (HP), but its low stability restricts its topical administration. This study investigates how “free” HP-rich SJW extract (incorporated into a bigel; B/SJW) and extract ...
Yoana Sotirova, Yoana Kiselova-Kaneva, Deyana Vankova, Oskan Tasinov, Diana Ivanova, Hristo Popov, Minka Hristova, Krastena Nikolova, Velichka Andonova   +8 more
doaj   +1 more source

Improved Bioactivity of the Natural Product 5‑Lipoxygenase Inhibitor Hyperforin by Encapsulation into Polymeric Nanoparticles

, 2020
Hyperforin, a highly hydrophobic prenylated acylphloroglucinol from the medical plant St. John’s Wort, possesses anti-inflammatory properties and suppresses the formation of proinflammatory leukotrienes by inhibiting the key enzyme 5-lipoxygenase (5-LO).
Anja Traeger, Anja Traeger (1797817), Christian Kretzer, Stephanie Schubert, Michael Gottschaldt, Oliver Werz, Michael Gottschaldt (1667701), Ulrich S. Schubert, Susanna Voelker (8423649), Oliver Werz (468489), Ulrich S. Schubert (411267), Blerina Shkodra-Pula (8423652), Stephanie Schubert (354012), Blerina Shkodra-Pula, Susanna Voelker, Christian Kretzer (6061916)   +15 more
core   +1 more source

Acid Sphingomyelinase Impacts Canonical Transient Receptor Potential Channels 6 (TRPC6) Activity in Primary Neuronal Systems

Cells, 2020
The acid sphingomyelinase (ASM)/ceramide system exhibits a crucial role in the pathology of major depressive disorder (MDD). ASM hydrolyzes the abundant membrane lipid sphingomyelin to ceramide that regulates the clustering of membrane proteins via ...
Stefanie Zeitler, Fabian Schumacher, Juliana Monti, Daniela Anni, Debarpan Guhathakurta, Burkhard Kleuser, Kristina Friedland, Anna Fejtová, Johannes Kornhuber, Cosima Rhein   +9 more
doaj   +1 more source

Hyperforin changes the zinc-storage capacities of brain cells.

, 2011
International audienceIn vitro and in vivo experiments were carried out to investigate the consequences on brain cells of a chronic treatment with hyperforin, a plant extract known to dissipate the mitochondrial membrane potential and to release Zn(2 ...
Gibon, Julien, Richaud, Pierre, Bouron, Alexandre, Julien Gibon, Alexandre Bouron, Pierre Richaud   +5 more
core   +1 more source

Secondary Metabolites of Hypericum leptophyllum Hochst., an Endemic Turkish Species

The Scientific World Journal, 2012
In the present study, the presence of the phloroglucinol derivative hyperforin, the naphthodianthrones hypericin and pseudohypericin, the phenylpropane chlorogenic acid and the flavonoids rutin, hyperoside, kaempferol, isoquercetine, quercitrine, and ...
Necdet Camas, Jolita Radusiene, Zydrunas Stanius, Omer Caliskan, Cuneyt Cirak   +4 more
doaj   +1 more source

Avaliação pré-clínica da atividade do tipo antidepressiva de quatro preparações comerciais de Hypericum perforatum e a sua correlação com os teores de hiperforina [PDF]

, 2009
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaPreparações comerciais de Hypericum perforatum (erva-de-São-João; ESJ) são bastante populares, de interesse comercial,
Petzsch, Dirk Gerhard
core  

Exposure of LS-180 Cells to Drugs of Diverse Physicochemical and Therapeutic Properties Up-regulates P-glycoprotein Expression and Activity

Journal of Pharmacy & Pharmaceutical Sciences, 2011
Purpose. Drug transporters are increasingly recognized as important determinants of variability in drug disposition and therapeutic response, both in pre-clinical and clinical stages of drug development process.
Alaa H Abuznait, Shawn G Patrick, Amal Kaddoumi   +2 more
doaj   +1 more source

Hyperforin - a key constituent of St. Johns wort specifically activates TRPC6 channels

, 2007
Hyperforin, a bicyclic polyprenylated acylphloroglucinol derivative, is the main active principle of St. Johns wort extract responsible for its antidepressive profile.
Mueller, M., Gollasch, M., Mueller, W.E., Essin, K., Henke, B., Kazanski, V., Leuner, K., Harteneck, C.   +7 more
core   +1 more source