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Hyperinsulinemia Associated Depression
Clinical Medicine Insights: Endocrinology and Diabetes, 2022 Hyperinsulinemia promotes fat accumulation, causing obesity. Being an inflammatory state, obesity can induce further inflammation and is a risk factor for HPA (hypothalamic pituitary axis) dysregulation through hypercortisolism-related hyperglycemia.
Haider Sarwar +12 more
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Hyperinsulinemia in Obesity, Inflammation, and Cancer [PDF]
Diabetes & Metabolism Journal, 2021 The relative insufficiency of insulin secretion and/or insulin action causes diabetes. However, obesity and type 2 diabetes mellitus can be associated with an absolute increase in circulating insulin, a state known as hyperinsulinemia.
Anni M.Y. Zhang +3 more
doaj +7 more sources
In Vitro Chronic Hyperinsulinemia Induces Remodelling of Vascular Smooth Muscle Cells from Young Men and Women in a Sex Hormone Independent Manner [PDF]
PathophysiologyElevated circulating insulin levels between 80 and 100 µU/mL characterize hyperinsulinemia, which often leads to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes (T2D).
Ashley Jazzar +3 more
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Valproate-Related Hyperinsulinemia
Pediatric Neurology Briefs, 2006 Changes in insulin metabolism during treatment with valproate (VPA) were investigated in a study of 51 patients receiving monotherapy (31 male and 20 female) and 45 healthy controls at University of Oulu, and Hospital of Children and Adolescents ...
J Gordon Millichap
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Hyperinsulinemia, Insulin Resistance, and Hypertension
Journal of Cardiovascular Pharmacology, 1994 Obesity is the most common reason for insulin resistance with consequent hyperinsulinemia. Other reasons for hyperinsulinemia are type II diabetes mellitus and a genetic predisposition with a family history of hypertension. Hyperinsulinemia is considered to cause blood pressure elevation and is generally accepted as an independent risk factor for ...
Gerd Bönner
openalex +4 more sources
Frontiers in Clinical Diabetes and Healthcare, 2023 ObjectiveThis study aimed to investigate the clinical implications of fasting serum insulin (FINS) levels in subjects with type 2 diabetes who were receiving insulin therapy.MethodsA total of 1,553 subjects with type 2 diabetes [774 subjects who had ...
Lingli Zhou +8 more
doaj +1 more source
Acute effects of euglycemic‐hyperinsulinemia on myocardial contractility in male mice
Physiological Reports, 2022 Type 2 diabetes and obesity are associated with increased risk of cardiovascular disease, including heart failure. A hallmark of these dysmetabolic states is hyperinsulinemia and decreased cardiac reserve.
Satya Murthy Tadinada +4 more
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Aging Reduces Insulin Clearance in Mice
Frontiers in Endocrinology, 2021 Hyperinsulinemia is frequently associated with aging and may cause insulin resistance in elderly. Since insulin secretion and clearance decline with age, hyperinsulinemia seems to be maintained, primarily, due to a decrease in the insulin clearance.
Carine Marmentini +8 more
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Hyperinsulinemia predisposes to NAFLD [PDF]
Indian Journal of Clinical Biochemistry, 2008 Metabolic syndrome contributes to pathogenesis of Type-2 diabetes and CAD. Insulin Resistance is the key factor of metabolic syndrome implicated in development of Non Alcoholic Fatty Liver Disease (NAFLD). In present study we have investigated the prevalence of NAFLD in metabolic syndrome and contribution of metabolic risk factors in causation of NAFLD
Hemant Mishra +4 more
openaire +3 more sources
Frontiers in Genetics, 2021 Dipeptidyl peptidase-4 (DPP4) can influence lipid homeostasis and atherosclerosis progression. We aimed to assess the association of DPP4 gene polymorphisms with hypoalphalipoproteinemia and DPP4 serum levels, in a cohort of Mexican individuals.
Gilberto Vargas-Alarcón +9 more
doaj +1 more source