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Hyperinsulinemia in Obesity, Inflammation, and Cancer [PDF]
Diabetes & Metabolism Journal, 2021 The relative insufficiency of insulin secretion and/or insulin action causes diabetes. However, obesity and type 2 diabetes mellitus can be associated with an absolute increase in circulating insulin, a state known as hyperinsulinemia.
Anni M.Y. Zhang +3 more
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In Vitro Chronic Hyperinsulinemia Induces Remodelling of Vascular Smooth Muscle Cells from Young Men and Women in a Sex Hormone Independent Manner [PDF]
PathophysiologyElevated circulating insulin levels between 80 and 100 µU/mL characterize hyperinsulinemia, which often leads to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes (T2D).
Ashley Jazzar +3 more
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Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. [PDF]
Journal of Clinical Investigation, 1991 Hyperinsulinemia may contribute to hypertension by increasing sympathetic activity and vascular resistance. We sought to determine if insulin increases central sympathetic neural outflow and vascular resistance in humans.
Erling A. Anderson +4 more
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Dysregulation of Metabolic Peptides in the Gut–Brain Axis Promotes Hyperinsulinemia, Obesity, and Neurodegeneration [PDF]
BiomedicinesMetabolic peptides can influence metabolic processes and contribute to both inflammatory and/or anti-inflammatory responses. Studies have shown that there are thousands of metabolic peptides, made up of short chains of amino acids, that the human body ...
Camille Green +4 more
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Dysregulation of Metabolic Peptides Precedes Hyperinsulinemia and Inflammation Following Exposure to Rotenone in Rats [PDF]
CellsRotenone, a naturally occurring compound derived from the roots of tropical plants, is used as a broad-spectrum insecticide, piscicide, and pesticide.
Vandana Zaman +3 more
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International Journal of Molecular Sciences, 2021 For many years, the dogma has been that insulin resistance precedes the development of hyperinsulinemia. However, recent data suggest a reverse order and place hyperinsulinemia mechanistically upstream of insulin resistance.
J. Janssen
semanticscholar +1 more source
Journal of Clinical Medicine, 2022 Metabolic derangement with poor glycemic control accompanying overweight and obesity is associated with chronic low-grade inflammation and hyperinsulinemia.
G. Püschel, J. Klauder, J. Henkel
semanticscholar +1 more source
Frontiers in Clinical Diabetes and Healthcare, 2023 ObjectiveThis study aimed to investigate the clinical implications of fasting serum insulin (FINS) levels in subjects with type 2 diabetes who were receiving insulin therapy.MethodsA total of 1,553 subjects with type 2 diabetes [774 subjects who had ...
Lingli Zhou +8 more
doaj +1 more source
Use of the SGLT2 inhibitor canagliflozin for control of refractory equine hyperinsulinemia and laminitis [PDF]
Open Veterinary Journal, 2022 Background: Hyperinsulinemia associated with pituitary pars intermedia dysfunction (PPID) and/or equine metabolic syndrome (EMS) is well documented to put horses at high risk of laminitis.
Eleanor M. Kellon, Kathleen M. Gustafson
doaj +1 more source
Nature Communications, 2021 Accumulating evidence indicates that obesity with its associated metabolic dysregulation, including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of cancers including postmenopausal breast cancer.
Manasi Das +10 more
semanticscholar +1 more source