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Hyperinsulinemia in Obesity, Inflammation, and Cancer [PDF]
Diabetes & Metabolism Journal, 2021 The relative insufficiency of insulin secretion and/or insulin action causes diabetes. However, obesity and type 2 diabetes mellitus can be associated with an absolute increase in circulating insulin, a state known as hyperinsulinemia.
Anni M.Y. Zhang +3 more
doaj +8 more sources
International Journal of Molecular Sciences, 2021 For many years, the dogma has been that insulin resistance precedes the development of hyperinsulinemia. However, recent data suggest a reverse order and place hyperinsulinemia mechanistically upstream of insulin resistance.
J. Janssen
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Nature Communications, 2021 Accumulating evidence indicates that obesity with its associated metabolic dysregulation, including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of cancers including postmenopausal breast cancer.
Lesley G Ellies +2 more
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Pathophysiology of Prediabetes Hyperinsulinemia and Insulin Resistance in the Cardiovascular System [PDF]
BiomedicinesHyperinsulinemia refers to an elevated level of circulating insulin (80 and 100 µU/mL), often leading to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes (T2D).
Ghassan Bkaily +3 more
doaj +2 more sources
In Vitro Chronic Hyperinsulinemia Induces Remodelling of Vascular Smooth Muscle Cells from Young Men and Women in a Sex Hormone Independent Manner [PDF]
PathophysiologyElevated circulating insulin levels between 80 and 100 µU/mL characterize hyperinsulinemia, which often leads to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes (T2D).
Ashley Jazzar +3 more
doaj +2 more sources
Hyperinsulinemia: An Early Indicator of Metabolic Dysfunction
Journal of the Endocrine Society, 2019 Hyperinsulinemia is strongly associated with type 2 diabetes. Racial and ethnic minority populations are disproportionately affected by diabetes and obesity-related complications.
Dylan Thomas +2 more
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Nature Communications, 2018 M2a-subtype macrophage activation is known to be impaired in obesity, although the underlying mechanisms remain poorly understood. Herein, we demonstrate that, the IL-4/Irs2/Akt pathway is selectively impaired, along with decreased macrophage Irs2 ...
Tetsuya Kubota +2 more
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International Journal of Cancer, 2017 Obesity, metabolic syndrome and type 2 diabetes are associated with cancer‐related mortality. We assessed whether hyperinsulinemia is a risk factor for cancer death in nonobese people without diabetes.
Tetsuro Tsujimoto
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Gene-environment interaction modifies the association between hyperinsulinemia and serum urate levels through SLC22A12 [PDF]
The Journal of Clinical InvestigationBACKGROUND Hyperinsulinemia and insulin resistance often accompany elevated serum urate levels (hyperuricemia), a highly heritable condition that triggers gout; however, the underlying mechanisms are unclear.METHODS We evaluated the association between ...
Wataru Fujii +8 more
doaj +2 more sources
Role of Hyperinsulinemia and Insulin Resistance in Hypertension: Metabolic Syndrome Revisited
Canadian Journal of Cardiology, 2020 Alexandre A Da Silva +2 more
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