Results 91 to 100 of about 4,983 (216)

The universal role of adaptive transcription in health and disease

The FEBS Journal, EarlyView.
Adaptive transcription via molecules such as CREB, MEF2, SRF, AP1, Nr4a1, and Egr1 constitutes a universal mechanism for directed cell state transitions in health and disease. These molecules are involved in physiological adaptation processes, pathological maladaptations, curative adaptations, and development of resistance to treatment.
Thomas Lissek
wiley   +1 more source

Stbd1 stimulates AMPK signaling and alleviates insulin resistance in an in vitro hepatocyte model

The FEBS Journal, EarlyView.
Stbd1 is an N‐myristoylated, ER‐resident, glycogen‐binding protein whose loss‐of‐function has been associated with insulin resistance. We report that AML12 hepatocytes overexpressing either N‐myristoylated Stbd1 or a non‐N‐myristoylated variant display enhanced AMPK signaling and improved insulin sensitivity, independently of differences in glycogen ...
Andria Theodoulou, Thilo Speckmann, Louiza Potamiti, Otto Baba, Tsuyoshi Morita, Anthi Drousiotou, Mihalis I. Panayiotidis, Annette Schürmann, Petros P. Petrou   +8 more
wiley   +1 more source

A non‐redundant role of EAAT3 for ATP synthesis mediated by GDH in dopaminergic neuronal cells: a new avenue for glutamate metabolism and protection in Parkinson's disease

The FEBS Journal, EarlyView.
Parkinson's disease (PD) is a severe brain disorder caused by the loss of dopaminergic neurons. This study found that activating the enzyme glutamate dehydrogenase (GDH), by using the GDH activator BCH, protects cells and improves their energy production. It also highlights the previously undescribed role of EAAT3 in GDH‐dependent protection against PD
Alessandra Preziuso, Tiziano Serfilippi, Marwa Toujani, Valentina Terenzi, Salvatore Amoroso, Simona Magi, Vincenzo Lariccia, Silvia Piccirillo   +7 more
wiley   +1 more source

A systematic review of prevention strategies for type 2 diabetes in First Nations children and young people

Pediatric Obesity, EarlyView.
Summary Introduction There is a high prevalence of type 2 diabetes (T2D) in First Nations populations worldwide, increasingly at younger ages. This review aims to identify interventions for the prevention of T2D in First Nations children and young people aged 4–25 years.
Marylin Carino, Jonathan Nguyen, Ru Hui New, Renae Kirkham, Louise Maple‐Brown, Shiree Mack, Diana MacKay, Angela Titmuss   +7 more
wiley   +1 more source

Study of mast cell count in skin tags

Indian Journal of Dermatology, 2007
Background: Skin tags or acrochordons are common tumors of middle-aged and elderly subjects. They consist of loose fibrous tissue and occur mainly on the neck and major flexures as small, soft, pedunculated protrusions.
Zaher Hesham, El Safoury Omar, El Komy Mohamed Hussein, Mahmoud Sara, El Hameed Hanan   +4 more
doaj  

Development of Obesity: The Driver and the Passenger

Diabetes, Metabolic Syndrome and Obesity, 2020
Wolfgang Kopp Diagnostikzentrum Graz, Graz, 8043, AustriaCorrespondence: Wolfgang KoppFormer Head of Diagnostikzentrum (retired), Mariatrosterstraße 41, Graz 8043, AustriaEmail w.kopp@weiz.ccAbstract: Obesity has reached epidemic proportions and is
Kopp W
doaj  

Influence of Continuous Physiologic Hyperinsulinemia on Glucose Kinetics and Counterregulatory Hormones in Normal and Diabetic Humans [PDF]

, 1979
Luigi Saccà, Robert Sherwin, Rosa Hendler, Philip Felig   +3 more
openalex   +1 more source

Individualized Effects of Weight Gain in Adulthood on the Development of MASLD in Japanese Non‐Obese Individuals

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background This study aimed to estimate the individualized effect of weight change since age 20 on the development of metabolic dysfunction–associated steatotic liver disease (MASLD) in Japanese non‐obese individuals. We also assessed the clinical characteristics of high‐risk individuals with weight gain. Method This retrospective cohort study
Kaiji Fukamizo, Yasuhiro Hagiwara, Takeshi Kimura, Yutaka Matsuyama   +3 more
wiley   +1 more source

Accelerated Growth and Abnormal Glucose Tolerance in Young Female Rats Exposed to Fetal Hyperinsulinemia [PDF]

, 1987
M Chung-Ja, Nancy L Gelardi, William Oh
openalex   +1 more source

Neuroendocrine mechanisms responsible for elevated gonadotrophin‐releasing hormone and luteinising hormone pulses in polycystic ovary syndrome

Journal of Neuroendocrinology, EarlyView.
Abstract Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility in premenopausal individuals with ovaries worldwide. Despite the diagnostic features of anovulation, ovarian cysts, and hyperandrogenemia, which indicate that ovary dysfunction is the cause of the syndrome, changes in central neuroendocrine circuits are a ...
Aleisha M. Moore
wiley   +1 more source