Results 91 to 100 of about 86,017 (262)

Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski, Mahima Raju, Tracy Fitzsimmons, Ishraq Murshed, Timothy J. Price, Michael Penniment, Sudarsha Selva‐Nayagam, Tarik Sammour   +7 more
wiley   +1 more source

Signalling Pathways Implicated in Obesity Associated Cancers [PDF]

, 2014
Grant support: The Scottish Government's Rural and Environment Science and Analytical Services Division. Declaration of interest: The author declares that there is no conflict of interest.Peer reviewedPublisher ...
Drew, Janice E.
core   +1 more source

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, EarlyView.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Gene-environment interaction modifies the association between hyperinsulinemia and serum urate levels through SLC22A12

The Journal of Clinical Investigation
BACKGROUND Hyperinsulinemia and insulin resistance often accompany elevated serum urate levels (hyperuricemia), a highly heritable condition that triggers gout; however, the underlying mechanisms are unclear.METHODS We evaluated the association between ...
Wataru Fujii, Osamu Yamazaki, Daigoro Hirohama, Ken Kaseda, Emiko Kuribayashi-Okuma, Motonori Tsuji, Makoto Hosoyamada, Yuta Kochi, Shigeru Shibata   +8 more
doaj   +1 more source

Hyperinsulinemia Influences the Short-Term Efficiency of Laparoscopic Sleeve Gastrectomy for Patients with Obesity and Insulin Resistance

Diabetes, Metabolic Syndrome and Obesity, 2023
Zilong Yue,1,* Long Qian,2,* Yan Jin,1,* Yabin Xia,1 Hui Sha,1 Qin Wu,1 Kaifeng Hu1 1Department of Gastrointestinal Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, People’s Republic of China; 2General ...
Yue Z, Qian L, Jin Y, Xia Y, Sha H, Wu Q, Hu K   +6 more
doaj  

Placental pathology in gestational diabetes mellitus: Associations with neonatal outcomes and postpartum dysglycemia

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Gestational diabetes mellitus is associated with increased placental vascular and villous lesions compared with normoglycemic pregnancies. Distal villous immaturity was linked to adverse neonatal outcomes, while chorangiosis predicted postpartum maternal dysglycemia, highlighting the placenta as a marker of both neonatal risk and future maternal ...
Chutima Chavanisakun, Siriwan Tangjitgamol, Chadakarn Phaloprakarn   +2 more
wiley   +1 more source

Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts. [PDF]

, 2014
Insulin and adrenergic stimulation are two divergent regulatory systems that may interact under certain pathophysiological circumstances. Here, we characterized a complex consisting of insulin receptor (IR) and β2-adrenergic receptor (β2AR) in the heart.
Abel, E Dale, Chen, Xiongwen, Clark, Richard B, Fu, Qin, Li, Jing, Li, Ying, Liu, Yongming, Parikh, Dippal, Rawlings, Tenley, Riehle, Christian, Shi, Qian, Xiang, Yang K, Xu, Bing, Zhang, Yuan, Zhu, Yi   +14 more
core   +2 more sources

Association between history of fertility problems and pregnancy and birth complications: A longitudinal population‐based cohort study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
In this large cohort of women in Australia, a history of fertility problems was not independently associated with adverse pregnancy outcomes after adjustment. Observed risks were more likely attributable to shared underlying maternal health and lifestyle factors.
Cathryn A. Tully, Danielle Schoenaker, Leanne Pacella‐Ince, Allison M. Hodge, Jessica A. Grieger   +4 more
wiley   +1 more source

Insulin Regulates Lipolysis and Fat Mass by Upregulating Growth/Differentiation Factor 3 in Adipose Tissue Macrophages [PDF]

, 2019
学位記番号 ...
Bu, Yun, ブ, イュン, 歩, 云
core  

Associations Between Obesity, Diabetes Mellitus, and Pancreatic Cancer in the Japanese Population: A Mendelian Randomization Study

Cancer Science, EarlyView.
Our Mendelian Randomization analysis provides evidence supporting a causal association between genetic predisposition to T2D, independent of BMI, and an increased risk of pancreatic cancer in the Japanese population, corroborating findings from observational studies.
Yingsong Lin, Haruki Sasado, Naoki Sasahira, Makoto Ueno, Hiroshi Ishii, Naoto Egawa, Yasushi Adachi, Masato Ozaka, Satoshi Kobayashi, Yuriko N. Koyanagi, Sayaka Yamamoto, Hidemi Ito, Akira Narita, Mika Sakurai‐Yageta, Takuji Okusaka, Aya Kuchiba, Teruhiko Yoshida, Fumihiko Matsuda, Yoichiro Kamatani, Shiori Nakano, Taiki Yamaji, Norie Sawada, Aya Kadota, Kiyonori Kuriki, Takeshi Watanabe, Nobuo Fuse, Kengo Kinoshita, Naoki Nakaya, Yoichi Sutoh, Yayoi Otsuka‐Yamasaki, Kozo Tanno, Ken Suzuki, Toshimasa Yamauchi, Takashi Kadowaki, BioBank Japan, Motoki Iwasaki, Sho Nakamura, Atsushi Hozawa, Atsushi Shimizu, Shogo Kikuchi, Masahiro Nakatochi, Keitaro Matsuo   +41 more
wiley   +1 more source