Results 111 to 120 of about 103,854 (365)

Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance*

Journal of Biological Chemistry, 2015
Background: Enhanced hepatic expression of the fatty acid transporter Cd36 correlates with liver fat accumulation, hepatosteatosis, insulin resistance, and hyperinsulinemia.
Pär Steneberg, A. Sykaras, Fredrik Backlund, Jurate Straseviçiene, I. Söderström, H. Edlund   +5 more
semanticscholar   +1 more source

Effects of Sofosbuvir/Velpatasvir Therapy on Extrahepatic Manifestations in Patients With Type 2 Diabetes and Chronic Hepatitis C: Insights From a Nationwide Hepatitis C Virus Registry in Taiwan

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study examines the impact of hepatitis C virus (HCV) eradication through sofosbuvir/velpatasvir (SOF/VEL) treatment on glycated hemoglobin (HbA1c) levels in patients with chronic hepatitis C and type 2 diabetes mellitus (T2DM). Utilizing data from the Taiwan HCV Registry, a retrospective analysis was conducted on 2180 patients who met the
Szu‐Jen Wang, Te‐Sheng Chang, Ching‐Chu Lo, Chao‐Hung Hung, Chien‐Wei Huang, Lee‐Won Chong, Pin‐Nan Cheng, Ming‐Jong Bair, Ming‐Lun Yeh, Cheng‐Yuan Peng, Chien‐Yu Cheng, Jee‐Fu Huang, Chih‐Lang Lin, Chi‐Chieh Yang, Hsing‐Tao Kuo, Tsai‐Yuan Hsieh, Tzong‐Hsi Lee, Pei‐Lun Lee, Wen‐Chih Wu, Chih‐Lin Lin, Wei‐Wen Su, Sheng‐Shun Yang, Chia‐Chi Wang, Jui‐Ting Hu, Lein‐Ray Mo, Chun‐Ting Chen, Yi‐Hsiang Huang, Chun‐Chao Chang, Chia‐Sheng Huang, Guei‐Ying Chen, Chien‐Neng Kao, Chi‐Ming Tai, Chun‐Jen Liu, Mei‐Hsuan Lee, Pei‐Chien Tsai, Shu‐Chi Wang, Chia‐Yen Dai, Jia‐Horng Kao, Han‐Chieh Lin, Wang‐Long Chuang, Kuo‐Chih Tseng, Chi‐Yi Chen, Chung‐Feng Huang, Ming‐Lung Yu   +43 more
wiley   +1 more source

High‐Fat Diet–Wheat Gluten Interactions in HLA‐DQ8 Transgenic Mice

Molecular Nutrition &Food Research, EarlyView.
This study shows how eating a high‐fat diet (HFD) and gluten together influences inflammation, energy balance, and immune responses in HLA‐DQ8 transgenic (DQ8 tg) mice. These findings may provide new insights into how specific dietary components interact to impact metabolic and immune‐related disorders.
Yuri Haneishi, Lucia Treppiccione, Vera Rotondi Aufiero, Francesco Maurano, Saya Watanabe, Diomira Luongo, Giuseppe Mazzarella, Junki Miyamoto, Mauro Rossi   +8 more
wiley   +1 more source

Effects of balloon injury on neointimal hyperplasia in steptozotocin-induced diabetes and in hyperinsulinemic nondiabetic pancreatic islet-transplanted rats. [PDF]

, 2001
BACKGROUND: The mechanisms of increased neointimal hyperplasia after coronary interventions in diabetic patients are still unknown. METHODS AND RESULTS: Glucose and insulin effects on in vitro vascular smooth muscle cell (VSMC) proliferation and ...
Carriero M.V., Cavuto L., Chiariello M., Chieffo A., Coppola C., Davalli A.M., Di Lorenzo E., ESPOSITO, GIOVANNI, Indolfi C., Pardo F., PERRINO, CINZIA, RAPACCIUOLO, ANTONIO, STABILE, EUGENIO, Torella D.   +13 more
core  

Hyperinsulinemia and insulin resistance : What comes first ? [PDF]

, 2010
Background 1) Classical explanation : Classical explanation of diabetic pathophysiology states that obesity induced insulin resistance develops first and is followed by compensatory hyperinsulinnemia.
Milind M. Watve, Pramod P. Patil
core   +2 more sources

The use of octreotide in pediatric patients: Practical applications for gastrointestinal disorders and beyond: A narrative review

Nutrition in Clinical Practice, EarlyView.
Abstract Somatostatin is a naturally occurring polypeptide hormone that exerts its effect on the gastrointestinal tract by reducing exocrine and endocrine secretion, resulting in decreased motility, gastric emptying, splanchnic blood flow, fat absorption, lymphatic flow, and gallbladder contraction.
Bailey Dunn, Megan Foxe, Kathy Hunter Sprott, Jessica E. Hook, Candi Jump   +4 more
wiley   +1 more source

Choice of method of diagnosis hypogonadism in obesity and metabolic syndrome in men

Андрология и генитальная хирургия, 2015
Nowadays, obesity and metabolic syndrome are considered as symptoms of male hypogonadism, which underlines the need for hormonal screening in these patients. However, remain unsolved some questions of laboratory diagnostics testosterone deficiency.
E. A. Kuznetsova, A. S. Adamchik, N. P. Goncharov, G. V. Katsiya   +3 more
doaj   +1 more source

Two variants on T2DM susceptible gene HHEX are associated with CRC risk in a Chinese population [PDF]

, 2016
Increasing amounts of evidence has demonstrated that T2DM (Type 2 Diabetes Mellitus) patients have increased susceptibility to CRC (colorectal cancer).
Feng, Jue-Ping, Gao, Chang, Jiang, An-Li, Li, Min, Lin, Mei, Liu, Jian-Ping, Su, Yan-Wei, Sun, Rui, Wang, Ya-Ping, Xie, Yan, Xiong, Ling-Fan, Xiong, Ying-Ying   +11 more
core   +3 more sources

The effects of acute hyperinsulinemia on bone metabolism

Endocrine Connections, 2015
Insulin signaling in bone-forming osteoblasts stimulates bone formation and promotes the release of osteocalcin (OC) in mice. Only a few studies have assessed the direct effect of insulin on bone metabolism in humans.
K. Ivaska, M. K. Heliövaara, P. Ebeling, M. Bucci, V. Huovinen, H. Väänänen, P. Nuutila, H. Koistinen   +7 more
semanticscholar   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source