Results 141 to 150 of about 4,983 (216)

Global warming and obesity: External heat exposure as a modulator of energy balance

FASEB BioAdvances, Volume 7, Issue 4, April 2025.
Core body temperature regulation can significantly influence metabolic processes to maintain energy balance. For example, geographic and environmental factors (global warming) can affect obesity rates and can be tracked along latitudinal boundaries.
Imani Muhammad, Francene Steinberg, Jennifer Larsen, Robert B. Rucker   +3 more
wiley   +1 more source

Association of Lifestyle‐Induced Weight Loss With Gene Expression in Subcutaneous Adipose Tissue in Metabolic Syndrome

Journal of Diabetes, Volume 17, Issue 4, April 2025.
ABSTRACT Aims Lifestyle‐induced weight loss (LIWL) is considered an effective therapy for the treatment of metabolic syndrome (MetS). The role of differentially expressed genes (DEGs) in adipose tissue function and in the success of LIWL in MetS is still unclear.
Silke Zimmermann, Kirsten Roomp, Hans‐Jonas Meyer, Akash Mathew, Manuel Florian Struck, Matthias Blüher, Hugo N. G. Martin, Maria Keller, Kathrin Landgraf, Antje Körner, Anne Hoffmann, Yvonne Böttcher, Kathleen Biemann, Adhideb Ghosh, Christian Wolfrum, Falko Noé, Berend Isermann, Jochen G. Schneider, Ronald Biemann   +18 more
wiley   +1 more source

Primary versus secondary recurrent pregnancy losses: Clinical findings and live birth rate after comprehensive work‐up and personalized management

Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 4, Page 697-706, April 2025.
Recurrent pregnancy loss (RPL) is a heterogeneous multifactorial syndrome. A customized management can lead to a good pregnancy outcome in more than a half of cases. Age <40 and AMH >1 ng/mL are the major positive predictors of live birth rate in RPL women.
Chiara Tersigni, Marianna Onori, Giuliana Beneduce, Fabio Sannino, Rita Franco, Andrea Busnelli, Chiara Granieri, Domenico Milardi, Alfredo Pontecorvi, Antonio Lanzone, Giovanni Scambia, Nicoletta Di Simone   +11 more
wiley   +1 more source

Inhibition of the upregulated phosphodiesterase 4D isoforms improves SERCA2a function in diabetic cardiomyopathy

British Journal of Pharmacology, Volume 182, Issue 7, Page 1487-1507, April 2025.
Abstract Background and Purpose Sarcoplasmic reticulum Ca2+‐ATPase (SERCA2a) is impaired in heart failure. Phosphodiesterases (PDEs) are implicated in the modulation of local cAMP signals and protein kinase A (PKA) activity essential for cardiac function.
Zhenduo Zhu, Qiuyun Guan, Bing Xu, Sherif Bahriz, Ao Shen, Toni M. West, Yu Zhang, Bingqing Deng, Wei Wei, Yongsheng Han, Qingtong Wang, Yang K. Xiang   +11 more
wiley   +1 more source

How ‘miracle’ weight‐loss semaglutide promises to change medicine but can we afford the expense?

British Journal of Pharmacology, Volume 182, Issue 8, Page 1651-1670, April 2025.
Obesity is a complex and growing global concern, affecting one in eight individuals and compromising health, quality of life and life expectancy. It carries significant metabolic, cardiovascular, oncological, hepatorenal, skeletal and psychiatric risks, imposing substantial costs on health‐care systems.
Ralf Weiskirchen, Amedeo Lonardo
wiley   +1 more source

Biological Effects of Dietary Restriction on Alzheimer's Disease: Experimental and Clinical Investigations

CNS Neuroscience &Therapeutics, Volume 31, Issue 4, April 2025.
This review explores the role of dietary restriction as a non‐pharmacological strategy in the prevention and treatment of Alzheimer's disease, focusing on its potential mechanisms and its association with AD pathologies. ABSTRACT Backgrounds Dementia can impose a heavy economic burden on both society and families.
Zijiao Liu, Jun Zhang, Fei Jiang, Cong Liu, Yaping Shao, Weidong Le   +5 more
wiley   +1 more source

Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man. [PDF]

, 1996
Asle Aarsland, David L. Chinkes, Robert R. Wolfe   +2 more
openalex   +1 more source

Impact of TCF7L2 rs7903146 on clinical presentation and risk of complications in patients with type 2 diabetes

Diabetes, Obesity and Metabolism, Volume 27, Issue 4, Page 2002-2011, April 2025.
Abstract Aims TCF7L2 rs7903146 is the most impactful single genetic risk variant for type 2 diabetes. However, its role on disease progression, complications and mortality among people with type 2 diabetes at diagnosis remains unclear. Materials and Methods We assessed the per allele impact of the rs7903146 T‐allele on clinical characteristics and ...
Aleksander L. Hansen, Mette K. Andersen, Leonie M. Engelhard, Charlotte Brøns, Torben Hansen, Jens S. Nielsen, Peter Vestergaard, Kurt Højlund, Niels Jessen, Michael H. Olsen, Reimar W. Thomsen, Allan Vaag   +11 more
wiley   +1 more source

Sympathetic Nerve Hyperactivity Precedes Hyperinsulinemia and Blood Pressure Elevation in a Young, Nonobese Japanese Population [PDF]

, 1997
Kazuko Masuo
openalex   +1 more source

Oral TIX100 protects against obesity‐associated glucose intolerance and diet‐induced adiposity

Diabetes, Obesity and Metabolism, Volume 27, Issue 4, Page 2223-2231, April 2025.
Abstract Aims Glucagon‐like peptide 1 receptor agonists and dual agonists have changed the treatment landscape of obesity and type 2 diabetes (T2D), but significant limitations have emerged due to their gastrointestinal side effects, loss of lean mass, and necessity for ongoing subcutaneous injections.
SeongHo Jo, Gu Jing, Junqin Chen, Guanlan Xu, Anath Shalev   +4 more
wiley   +1 more source