Results 21 to 30 of about 86,017 (262)

Hyperprolactinemia induced by hCG leads to metabolic disturbances in female mice [PDF]

, 2016
The metabolic syndrome is a growing epidemic; it increases the risk for diabetes, cardiovascular disease, fatty liver, and several cancers. Several reports have indicated a link between hormonal imbalances and insulin resistance or obesity.
Bonaventura, Maria Marta, Calandra, Ricardo Saul, Huhtaniemi, Ilpo T., Lux, Victoria Adela R., Poutanen, Matti, Ratner, Laura Daniela, Rulli, Susana Beatriz, Stevens, Guillermina   +7 more
core   +1 more source

A Potential Role for Endogenous Glucagon in Preventing Post-Bariatric Hypoglycemia

Frontiers in Endocrinology, 2020
Obesity and obesity-related diseases are major public health concerns that have been exponentially growing in the last decades. Bariatric surgery is an effective long-term treatment to achieve weight loss and obesity comorbidity remission. Post-bariatric
Carolina B. Lobato, Carolina B. Lobato, Sofia S. Pereira, Sofia S. Pereira, Sofia S. Pereira, Sofia S. Pereira, Marta Guimarães, Marta Guimarães, Marta Guimarães, Bolette Hartmann, Bolette Hartmann, Nicolai J. Wewer Albrechtsen, Nicolai J. Wewer Albrechtsen, Nicolai J. Wewer Albrechtsen, Linda Hilsted, Jens J. Holst, Jens J. Holst, Mário Nora, Mário Nora, Mariana P. Monteiro, Mariana P. Monteiro   +20 more
doaj   +1 more source

A multi-center study on glucometabolic response to bariatric surgery for different subtypes of obesity

Frontiers in Endocrinology, 2022
ObjectivesTo assess the benefit of a bariatric surgery in four artificial intelligence-identified metabolic (AIM) subtypes of obesity with respect to the improvement of glucometabolism and the remission of diabetes and hyperinsulinemia.MethodsThis ...
Yao Liu, Chunjun Sheng, Wenhuan Feng, Fang Sun, Jingjing Zhang, Jingjing Zhang, Ying Chen, Lili Su, Jia Liu, Lei Du, Xuyang Jia, Hui You, Xiu Huang, Shandong Wu, Shandong Wu, Shandong Wu, Ziwei Lin, Shen Qu   +17 more
doaj   +1 more source

Changes in insulin and insulin signaling in Alzheimer\u27s disease: Cause or consequence? [PDF]

, 2016
Individuals with type 2 diabetes have an increased risk for developing Alzheimer’s disease (AD), although the causal relationship remains poorly understood. Alterations in insulin signaling (IS) are reported in the AD brain.
Holtzman, David M, Macauley, Shannon L, Stanley, Molly   +2 more
core   +2 more sources

Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model. [PDF]

, 2018
Pancreatic ductal adenocarcinoma (PDAC) is a particularly deadly disease. Chronic conditions, including obesity and type-2 diabetes are risk factors, thus making PDAC amenable to preventive strategies.
Chang, Hui-Hua, Chou, Caroline Ei Ne, Dawson, David W, Eibl, Guido, French, Samuel, Hao, Fang, Hines, O Joe, Moro, Aune, Rozengurt, Enrique, Schmidt, Andrea I, Sinnett-Smith, James   +10 more
core   +2 more sources

Valproate Induced Obesity and Polycystic Ovaries

Pediatric Neurology Briefs, 1996
Fourteen (64%) of 22 women receiving valproate monotherapy for epilepsy had polycystic ovaries, hyperandrogenism, or both, in a study at the Departments of Neurology, Obstetrics and Gynecology, and Pediatrics, University of Oulu, Finland.
J Gordon Millichap
doaj   +1 more source

Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study. [PDF]

, 2011
ObjectiveDiabetic and prediabtic states, including insulin resistance, fasting hyperglycemia, and hyperinsulinemia, are associated with metabolic dysregulation.
Au, Rhoda, Beiser, Alexa S, Debette, Stephanie, Decarli, Charles, Fox, Caroline S, Himali, Jayandra J, Seshadri, Sudha, Tan, Zaldy S, Vasan, Ramachandran S, Wolf, Philip A   +9 more
core   +2 more sources

Hyperinsulinemia and oxidative stress

Physiological Research, 2002
The aim of the study was to compare the effect of short-term hyperglycemia and short-term hyperinsulinemia on parameters of oxidative stress in Wistar rats. Twenty male rats (aged 3 months, average body weight 325 g) were tested by hyperinsulinemic clamp (100 IU/l) at two different glycemia levels (6 and 12 mmol/l).
P, Kyselová, M, Zourek, Z, Rusavý, L, Trefil, J, Racek   +4 more
openaire   +2 more sources

Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats [PDF]

, 2013
Background: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expression pattern is unclear ...
Csonka, Csaba, Csont, Tamás Bálint, Fekete, Veronika, Ferdinandy, Péter, Gyémánt, Nóra, Kocsis-Fodor, Gabriella, Pipis, Judit, Puskás, László, Szűcs, Gergő, Sárközy, Márta, Zvara, Ágnes   +10 more
core   +3 more sources

Aldosterone status associates with insulin resistance in patients with heart failure-data from the ALOFT study [PDF]

, 2009
<b>Background</b>: Aldosterone plays a key role in the pathophysiology of heart failure. In around 50% of such patients, aldosterone 'escapes' from inhibition by drugs that interrupt the renin-angiotensin axis; such patients have a worse ...
Connell, J.M.C., Freel, E.M., Latini, R., Lewsey, J.D., Maggioni, A.P., McMurray, J.J.V., Pitt, B., Solomon, S., Tsorlalis, I.K.   +8 more
core   +1 more source