Results 21 to 30 of about 105,064 (356)
Acute effects of euglycemic‐hyperinsulinemia on myocardial contractility in male mice
Physiological Reports, 2022 Type 2 diabetes and obesity are associated with increased risk of cardiovascular disease, including heart failure. A hallmark of these dysmetabolic states is hyperinsulinemia and decreased cardiac reserve.
Satya Murthy Tadinada +4 more
doaj +1 more source
A causal role for hyperinsulinemia in obesity. [PDF]
Journal of Endocrinology, 2017 Insulin modulates the biochemical pathways controlling lipid uptake, lipolysis and lipogenesis at multiple levels. Elevated insulin levels are associated with obesity, and conversely, dietary and pharmacological manipulations that reduce insulin have occasionally been reported to cause weight loss.
N. Templeman +4 more
semanticscholar +4 more sources
What Regulates Basal Insulin Secretion and Causes Hyperinsulinemia?
Diabetes, 2021 We hypothesize that basal hyperinsulinemia is synergistically mediated by an interplay between increased oxidative stress and excess lipid in the form of reactive oxygen species (ROS) and long-chain acyl-CoA esters (LC-CoA).
B. Corkey, J. Deeney, M. Merrins
semanticscholar +1 more source
Hepatology Communications, EarlyView., 2022 Abstract Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence and severity globally, prompting noninvasive testing, yet limited data exist on noninvasive liver tests (NITs) including transient elastography (TE) in ethnically diverse populations.
Anne‐Marieke van Dijk +6 more
wiley +1 more source
Hyperinsulinemia predisposes to NAFLD [PDF]
Indian Journal of Clinical Biochemistry, 2008 Metabolic syndrome contributes to pathogenesis of Type-2 diabetes and CAD. Insulin Resistance is the key factor of metabolic syndrome implicated in development of Non Alcoholic Fatty Liver Disease (NAFLD). In present study we have investigated the prevalence of NAFLD in metabolic syndrome and contribution of metabolic risk factors in causation of NAFLD
Hemant Mishra +4 more
openaire +3 more sources
Cell Reports, 2021 Summary: Hepatic lipid accumulation in obesity correlates with the severity of hyperinsulinemia and systemic insulin resistance. Obesity-induced hepatocellular lipid accumulation results in hepatocyte depolarization.
Caroline E. Geisler +10 more
doaj +1 more source
A case of acanthosis nigricans in a HIV-infected patient [PDF]
, 2020 Background: To date, very little information is available concerning the relationship between acanthosis nigricans (AN) and infection with human immunodeficiency virus type 1 (HIV-1).
De Vincentiis, Ludovica +5 more
core +1 more source
An Analysis into Metacognition and Family History of Diabetes Mellitus among First Year Medical Students [PDF]
Journal of Clinical and Diagnostic Research, 2017 Introduction: Medical course requires immense effort by the students to deal with vast curriculum and hence, the need to adopt metacognitive skill to cope up. Diabetes mellitus has an impact on cognition. Metacognition, being a component of cognition,
AK Sunitha Priya +3 more
doaj +1 more source
The effects of peripheral and central high insulin on brain insulin signaling and amyloid-β in young and old APP/PS1 mice [PDF]
, 2016 Hyperinsulinemia is a risk factor for late-onset Alzheimer's disease (AD). In vitro experiments describe potential connections between insulin, insulin signaling, and amyloid-β (Aβ), but in vivo experiments are needed to validate these relationships ...
Caesar, Emily E +9 more
core +2 more sources