Results 31 to 40 of about 95,820 (339)
Changes in insulin and insulin signaling in Alzheimer\u27s disease: Cause or consequence? [PDF]
, 2016 Individuals with type 2 diabetes have an increased risk for developing Alzheimer’s disease (AD), although the causal relationship remains poorly understood. Alterations in insulin signaling (IS) are reported in the AD brain.
Holtzman, David M +2 more
core +2 more sources
QTc Dispersion, Hyperglycemia, and Hyperinsulinemia [PDF]
Circulation, 1999 To the Editor: QTc dispersion is an important predictor of cardiac mortality. In the Rotterdam Study,1 persons in the highest tertile (>60 ms) relative to the lowest tertile (
MARFELLA F +2 more
openaire +4 more sources
Examining the role of insulin in the regulation of cardiovascular health [PDF]
, 2013 A substantial body of evidence has reported that insulin has direct actions on the cardiovascular system independent of its systemic effects on plasma glucose or lipids.
Salt, Ian P.
core +1 more source
The contribution of hyperinsulinemia to the hyperandrogenism of polycystic ovary syndrome
Journal of Metabolic Health, 2019 Background: Polycystic Ovary Syndrome (PCOS) is a very common endocrine disorder of young women. Aim: The proper treatment of PCOS requires a thorough understanding of the underlying cause of disease.
Nadia B. Pateguana, Alvin Janes
doaj +1 more source
Pediatric Reports, 2022 Background: Hyperinsulinemic hypoglycemia (HH) is an important cause of persistent hypoglycemia in newborns and infants. Recently, PMM2 (phosphomannomutase 2) mutation has been associated with HH, especially in conjunction with polycystic kidney disease (
Ratna Acharya, Kiran Upadhyay
doaj +1 more source
Hyperinsulinemia and insulin resistance : What comes first ? [PDF]
, 2010 Background 1) Classical explanation : Classical explanation of diabetic pathophysiology states that obesity induced insulin resistance develops first and is followed by compensatory hyperinsulinnemia.
Milind M. Watve, Pramod P. Patil
core +2 more sources
Regulation of Insulin Clearance by Non-Esterified Fatty Acids
Biomedicines, 2022 Insulin stores lipid in adipocytes and prevents lipolysis and the release of non-esterified fatty acids (NEFA). Excessive release of NEFA during sustained energy supply and increase in abdominal adiposity trigger systemic insulin resistance, including in
Sonia M. Najjar +8 more
doaj +1 more source
Maternal glucose and fatty acid kinetics and infant birth weight in obese women with type 2 diabetes [PDF]
, 2016 The objectives of this study were 1) to describe maternal glucose and lipid kinetics and 2) to examine the relationships with infant birth weight in obese women with pregestational type 2 diabetes during late pregnancy.
Cade, W. Todd +4 more
core +2 more sources
The effects of hyperinsulinemia on cochlear functions
Noise and Health, 2020 Hyperinsulinemia is the most common metabolic change associated with cochleovestibular diseases.We aimed to investigate the auditory functions in hyperinsulinemic individuals.A total of 164 patients were included in this case-control study. While 76 patients with insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR] of ≥2.5 ...
Cuneyd Anil +2 more
openaire +4 more sources
Pediatric Obesity, Volume 18, Issue 1, January 2023., 2023 Summary Objective To examine the association between maternal metabolic parameters in pregnancy and growth trajectories up to 5 years of age. Methods Data from mother–child pairs who participated in the ROLO study, a randomized trial examining the impact of a low glycaemic index diet on the recurrence of macrosomia, were analysed.
Helena C. Bartels +8 more
wiley +1 more source