Results 31 to 40 of about 103,854 (365)

Central Obesity and BMI Associated with Different Phenotypes of Polycystic Ovary Syndrome in Adolescent [PDF]

, 2017
Adipose tissue distribution is effective in metabolic complications resulting from obesity. Fat accumulation in the body, particularly increase in visceral fat, is a major risk factor of diabetes and cardiovascular diseases.
Akbaezadeh, M. (Marzieh), Behbahani, B. M. (Bahar)   +1 more
core   +3 more sources

A multi-center study on glucometabolic response to bariatric surgery for different subtypes of obesity

Frontiers in Endocrinology, 2022
ObjectivesTo assess the benefit of a bariatric surgery in four artificial intelligence-identified metabolic (AIM) subtypes of obesity with respect to the improvement of glucometabolism and the remission of diabetes and hyperinsulinemia.MethodsThis ...
Yao Liu, Chunjun Sheng, Wenhuan Feng, Fang Sun, Jingjing Zhang, Jingjing Zhang, Ying Chen, Lili Su, Jia Liu, Lei Du, Xuyang Jia, Hui You, Xiu Huang, Shandong Wu, Shandong Wu, Shandong Wu, Ziwei Lin, Shen Qu   +17 more
doaj   +1 more source

QTc Dispersion, Hyperglycemia, and Hyperinsulinemia [PDF]

Circulation, 1999
To the Editor: QTc dispersion is an important predictor of cardiac mortality. In the Rotterdam Study,1 persons in the highest tertile (>60 ms) relative to the lowest tertile (
MARFELLA F, ROSSI, Francesco, GIUGLIANO, Dario   +2 more
openaire   +4 more sources

MicroRNAs as Indicators of Malignancy in Pancreatic Ductal Adenocarcinoma (PDAC) and Cystic Pancreatic Lesions

Cells, 2022
The dysregulation of microRNAs has recently been associated with cancer development and progression in pancreatic ductal adenocarcinoma (PDAC) and cystic pancreatic lesions.
Christian Prinz, Leonard Fehring, Robin Frese   +2 more
doaj   +1 more source

The contribution of hyperinsulinemia to the hyperandrogenism of polycystic ovary syndrome

Journal of Metabolic Health, 2019
Background: Polycystic Ovary Syndrome (PCOS) is a very common endocrine disorder of young women. Aim: The proper treatment of PCOS requires a thorough understanding of the underlying cause of disease.
Nadia B. Pateguana, Alvin Janes
doaj   +1 more source

In vitro characterization of the effects of chronic insulin stimulation in mouse 3T3-L1 and human SGBS adipocytes

Adipocyte, 2020
Hyperinsulinemia is the hallmark of the development of insulin resistance and precedes the diagnosis of type 2 diabetes. Here we evaluated the effects of prolonged exposure (≥4 days) to high insulin doses (150 nM) in vitro in two adipose cell types ...
A. Rossi, M. Eid, J. Dodgson, G. Davies, B. Musial, M. Wabitsch, C. Church, D.C. Hornigold   +7 more
doaj   +1 more source

The effects of hyperinsulinemia on cochlear functions

Noise and Health, 2020
Hyperinsulinemia is the most common metabolic change associated with cochleovestibular diseases.We aimed to investigate the auditory functions in hyperinsulinemic individuals.A total of 164 patients were included in this case-control study. While 76 patients with insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR] of ≥2.5 ...
Cuneyd Anil, Arzu Or Koca, Hüseyin Samet Koca   +2 more
openaire   +4 more sources

Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus

MedComm, 2021
Diet‐induced obesity, the metabolic syndrome, type 2 diabetes (DIO/MetS/T2DM), and their adverse sequelae have reached pandemic levels. In mice, DIO/MetS/T2DM initiation involves diet‐dependent increases in lipids that activate hepatic atypical PKC (aPKC)
Mini P. Sajan, Barbara C. Hansen, Mildred Acevedo‐Duncan, Mark S. Kindy, Denise R. Cooper, Robert V. Farese   +5 more
doaj   +1 more source

Hypertriglyceridemia in equines with refractory hyperinsulinemia treated with SGLT2 inhibitors

Open Veterinary Journal, 2023
Background: Sodium-Glucose CoTransporter-2 [SGLT2] inhibitors, the -flozin group of drugs, which block glucose reuptake in the renal proximal tubule, are being increasingly used off-label to treat horses with refractory hyperinsulinemia. After two years
Eleanor M. Kellon, Kathleen M. Gustafson
doaj   +1 more source

High Prevalence of Insulin Resistance in Asymptomatic Patients with Acute Intermittent Porphyria and Liver-Targeted Insulin as a Novel Therapeutic Approach

Biomedicines, 2021
Acute porphyria attacks are associated with the strong up-regulation of hepatic heme synthesis and over-production of neurotoxic heme precursors. First-line therapy is based on carbohydrate loading.
Isabel Solares, Laura Izquierdo-Sánchez, Montserrat Morales-Conejo, Daniel Jericó, Francisco Javier Castelbón, Karol Marcela Córdoba, Ana Sampedro, Carlos Lumbreras, María Jesús Moreno-Aliaga, Rafael Enríquez de Salamanca, Pedro Berraondo, Antonio Fontanellas   +11 more
doaj   +1 more source