Results 41 to 50 of about 89,537 (288)

New prospects in the management of functional reproductive disorders associated with polycystic ovary syndrome

Медицинский совет, 2015
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age associated with hyperandrogenism, anovulatory infertility and metabolic disorders.
G. E. Chernukha, E. K. Kaprina, A. A. Naidukova   +2 more
doaj   +1 more source

Changes in insulin and insulin signaling in Alzheimer\u27s disease: Cause or consequence? [PDF]

, 2016
Individuals with type 2 diabetes have an increased risk for developing Alzheimer’s disease (AD), although the causal relationship remains poorly understood. Alterations in insulin signaling (IS) are reported in the AD brain.
Holtzman, David M, Macauley, Shannon L, Stanley, Molly   +2 more
core   +2 more sources

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Risk Assessment and Determination of Factors That Cause the Development of Hyperinsulinemia in School-Age Adolescents

Medicina, 2021
Background and Objectives: Hyperinsulinemia and insulin resistance are not synonymous; if the risk of developing insulin resistance in adolescents is monitored, they do not necessarily have hyperinsulinemia.
Igor Lukic, Nikola Savic, Maja Simic, Nevena Rankovic, Dragica Rankovic, Ljubomir Lazic   +5 more
doaj   +1 more source

A novel therapeutic strategy for pancreatic neoplasia using a novel RNAi platform targeting PDX-1 [PDF]

, 2011
Bi-functional shRNA (bi-shRNA), a novel RNA interference (RNAi) effector platform targeting PDX-1 utilizing a systemic DOTAP-Cholesterol delivery vehicle, was studied in three mouse models of progressive pancreatic neoplasia.
Charles Brunicardi, David Dawson, Donald Rao, Francesco DeMayo, John Nemunaitis, Kelly Stehling, Marie-Claude Gingras, Michael Norman, Nancy Templeton, Neil Senzer, Richard Gibbs, Shi-He Liu, William Fisher, Zhaohui Wang   +13 more
core   +1 more source

Adiponectin, in contrast to leptin, is not associated with body mass index, waist circumference and HOMA-IR in subjects of a west-African population [PDF]

, 2018
Factors associated with plasma levels of adiponectin and leptin were studied in adult subjects without diabetes from Cotonou in Benin (West‐Africa). Seventy (70) men and 45 women were included in the study.
Adehan, Grace, Adovoekpe, Diane, Amoussou-Guenou, Marcellin, Awede, Bonaventure, Azonbakin, Simon, Djrolo, Francois, Dossou, Emmanuel, MacFarlane, Niall G.   +7 more
core   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Aging Reduces Insulin Clearance in Mice

Frontiers in Endocrinology, 2021
Hyperinsulinemia is frequently associated with aging and may cause insulin resistance in elderly. Since insulin secretion and clearance decline with age, hyperinsulinemia seems to be maintained, primarily, due to a decrease in the insulin clearance.
Carine Marmentini, Gabriela M. Soares, Gabriela A. Bronczek, Silvano Piovan, Cecília E. Mareze-Costa, Everardo M. Carneiro, Antonio C. Boschero, Mirian A. Kurauti, Mirian A. Kurauti   +8 more
doaj   +1 more source

Study of Serum Leptin in Well-differentiated Thyroid Carcinoma: Correlation with Patient and Tumor Characteristics [PDF]

, 2014
Background There is a proven relationship between obesity and several cancers including breast, endometrium, colorectal, and esophagus. With the increasing incidence of both obesity and thyroid cancer, we designed the present study to investigate a ...
Abdel-Aziz, TE, Elwafa, RA, Elwafa, WA, Rehem, RA   +3 more
core   +1 more source

Impact of Body Weight Loss During Preoperative Chemoradiotherapy on Prognosis of Patients With Lower Rectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
The present study aimed to investigate the relationship between changes in body weight and composition during chemoradiotherapy, such as the psoas muscle mass index, visceral fat index, and subcutaneous fat index obtained from computed tomography images, and long‐term outcomes in rectal cancer patients.
Shinya Abe, Hiroaki Nozawa, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Yuichiro Yokoyama, Yuzo Nagai, Yuzo Harada, Takahide Shinagawa, Soichiro Ishihara   +9 more
wiley   +1 more source