Results 41 to 50 of about 47,507 (194)

Mechanism of the mitogenic influence of hyperinsulinemia [PDF]

Diabetology & Metabolic Syndrome, 2011
Either endogenous or exogenous hyperinsulinemia in the setting of insulin resistance promotes phosphorylation and activation of farnesyltransferase, a ubiquitous enzyme that farnesylates Ras protein. Increased availability of farnesylated Ras at the plasma membrane enhances mitogenic responsiveness of cells to various growth factors, thus contributing ...
openaire   +3 more sources

Hyperinsulinemia and Hyperfiltration in Renal Transplantation

Transplantation, 2009
Insulin-resistance hyperinsulinemia is a novel risk factor for renal disease in the general population. Glomerular hyperfiltration has been proposed as an early consequence of hyperinsulinemia.In this multicenter cohort study, we analyzed 202 patients without diabetes before or after renal transplantation during the first posttransplant year.
Patricia Delgado, Manuel Arias, Ricardo Lauzurica, Armando Torres, Irene Silva, Esteban Porrini, Meritxell Ibernon, Beatriz Bayés, Juan Manuel Moreno, Juan Manuel Diaz, Rocio Benitez, Ildefonso Lampreabe, Rosa Domínguez, Francisco Moreso, Antonio Osuna   +14 more
openaire   +5 more sources

Insulin resistance/hyperinsulinemia: an important cardiovascular risk factor that has long been underestimated

Frontiers in Cardiovascular Medicine
Cardiovascular mortality is still excessively high, despite the considerable progress made in the prevention and treatment of cardiovascular diseases.
Serafino Fazio, Valentina Mercurio, Loredana Tibullo, Valeria Fazio, Flora Affuso   +4 more
doaj   +1 more source

The role of hyperinsulinemia and insulin resistance in the pathogenesis of nephropathies in obesity (literature review)

Лечащий Врач, 2021
5.5% of children living in rural areas and 8.5% in urban areas in Russian Federation have obesity. Obesity leads to metabolic disorders that damaged kidneys.
L. V. Kutsenko, I. V. Zorin, A. A. Vyalkova, S. M. Konnova   +3 more
doaj   +1 more source

Insulin resistance and hyperinsulinemia

Journal of obstetrics and women's diseases, 2016
Resent data concerning the role of insulin resistance, hyperinsulinemia and ovarian aromatase deficiency in pathogenesis of polycystic ovary syndrome are presented.
Elena V. Misharina, Valetina L Borodina, Olga B. Glavnova, Marina A. Tarasova, Igor P Nicolaencov, Vladimir Vsevolodovich Potin   +5 more
openaire   +2 more sources

Phthalate and gallstones: the mediation of insulin

Frontiers in Public Health
BackgroundExposure to a mixture of environmental chemicals may cause gallstone, but the evidence remains equivocal. The current study aims to investigate the association between phthalate metabolites and gallstones, and to explore their mediators ...
Haoxian Tang, Haoxian Tang, Xuan Zhang, Xuan Zhang, Jingtao Huang, Jingtao Huang, Nan Luo, Nan Luo, Hongyu Chen, Hongyu Chen, Qinglong Yang, Qinglong Yang, Hanyuan Lin, Hanyuan Lin, Hao Hua   +14 more
doaj   +1 more source

METABOLIC SYNDROME X - PANDEMIC OF THE XXI CENTURY [PDF]

Саратовский научно-медицинский журнал, 2008
A survey of data found in scientific articles including the main points, structure, spreading and social importance of metabolic syndrome X as a real predictor of mortality level are presented.
Т.D. Kolopkova, V.V. Blinova, Yu.l. Skvortsov, V.G. Subbotina   +3 more
doaj  

Analysis of beta-cell maturity and mitochondrial morphology in juvenile non-human primates exposed to maternal Western-style diet during development

Frontiers in Endocrinology
IntroductionUsing a non-human primate (NHP) model of maternal Western-style diet (mWSD) feeding during pregnancy and lactation, we previously reported altered offspring beta:alpha cell ratio in vivo and insulin hyper-secretion ex vivo.
Darian T. Carroll, Allie Miller, Jennifer Fuhr, Jennifer Fuhr, Joseph M. Elsakr, Valerie Ricciardi, Alexa N. Del Bene, Stedman Stephens, Evan Krystofiak, Sarah R. Lindsley, Melissa Kirigiti, Diana L. Takahashi, Tyler A. Dean, Stephanie R. Wesolowski, Carrie E. McCurdy, Jacob E. Friedman, Kjersti M. Aagaard, Paul Kievit, Maureen Gannon, Maureen Gannon, Maureen Gannon, Maureen Gannon   +21 more
doaj   +1 more source

Androgens impair β-cell function in a mouse model of polycystic ovary syndrome by activating endoplasmic reticulum stress

Endocrine Connections, 2021
Background: Androgens excess results in endoplasmic reticulum (ER) stress, which is an important cause of β cells dysfunction. Here, we investigated the molecular regulation of androgens excess, ER stress, and β-cell function in polycystic ovary syndrome
Bo Zhu, Yumei Chen, Fang Xu, Xiaolu Shen, Xuanyu Chen, Jieqiang Lv, Songying Zhang   +6 more
doaj   +1 more source

Aging Reduces Insulin Clearance in Mice

Frontiers in Endocrinology, 2021
Hyperinsulinemia is frequently associated with aging and may cause insulin resistance in elderly. Since insulin secretion and clearance decline with age, hyperinsulinemia seems to be maintained, primarily, due to a decrease in the insulin clearance.
Carine Marmentini, Gabriela M. Soares, Gabriela A. Bronczek, Silvano Piovan, Cecília E. Mareze-Costa, Everardo M. Carneiro, Antonio C. Boschero, Mirian A. Kurauti, Mirian A. Kurauti   +8 more
doaj   +1 more source