Results 41 to 50 of about 105,064 (356)

The rs12617336 and rs17574 Dipeptidyl Peptidase-4 Polymorphisms Are Associated With Hypoalphalipoproteinemia and Dipeptidyl Peptidase-4 Serum Levels: A Case-Control Study of the Genetics of Atherosclerotic Disease (GEA) Cohort

Frontiers in Genetics, 2021
Dipeptidyl peptidase-4 (DPP4) can influence lipid homeostasis and atherosclerosis progression. We aimed to assess the association of DPP4 gene polymorphisms with hypoalphalipoproteinemia and DPP4 serum levels, in a cohort of Mexican individuals.
Gilberto Vargas-Alarcón, María del Carmen González-Salazar, Christian Vázquez-Vázquez, Adrián Hernández-Díaz Couder, Fausto Sánchez-Muñoz, Juan Reyes-Barrera, Sergio A. Criales-Vera, Marco Sánchez-Guerra, Citlalli Osorio-Yáñez, Rosalinda Posadas-Sánchez   +9 more
doaj   +1 more source

A multi-center study on glucometabolic response to bariatric surgery for different subtypes of obesity

Frontiers in Endocrinology, 2022
ObjectivesTo assess the benefit of a bariatric surgery in four artificial intelligence-identified metabolic (AIM) subtypes of obesity with respect to the improvement of glucometabolism and the remission of diabetes and hyperinsulinemia.MethodsThis ...
Yao Liu, Chunjun Sheng, Wenhuan Feng, Fang Sun, Jingjing Zhang, Jingjing Zhang, Ying Chen, Lili Su, Jia Liu, Lei Du, Xuyang Jia, Hui You, Xiu Huang, Shandong Wu, Shandong Wu, Shandong Wu, Ziwei Lin, Shen Qu   +17 more
doaj   +1 more source

MicroRNAs as Indicators of Malignancy in Pancreatic Ductal Adenocarcinoma (PDAC) and Cystic Pancreatic Lesions

Cells, 2022
The dysregulation of microRNAs has recently been associated with cancer development and progression in pancreatic ductal adenocarcinoma (PDAC) and cystic pancreatic lesions.
Christian Prinz, Leonard Fehring, Robin Frese   +2 more
doaj   +1 more source

Hyperprolactinemia induced by hCG leads to metabolic disturbances in female mice [PDF]

, 2016
The metabolic syndrome is a growing epidemic; it increases the risk for diabetes, cardiovascular disease, fatty liver, and several cancers. Several reports have indicated a link between hormonal imbalances and insulin resistance or obesity.
Bonaventura, Maria Marta, Calandra, Ricardo Saul, Huhtaniemi, Ilpo T., Lux, Victoria Adela R., Poutanen, Matti, Ratner, Laura Daniela, Rulli, Susana Beatriz, Stevens, Guillermina   +7 more
core   +1 more source

Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies [PDF]

, 2009
Introduction Chronic low-grade inflammation is a significant factor in the development of obesity associated diabetes. This is supported by recent studies suggesting endotoxin, derived from gut flora, may be key to the development of inflammation by ...
Al-Attas, Omar S, Alison L Harte, Khalid Al-Rubeaan, Nancy F da Silva, Nasser M Al-Daghri, Omar S Al-Attas, Philip G McTernan, Shaun L Sabico, Sudhesh Kumar   +8 more
core   +3 more sources

New prospects in the management of functional reproductive disorders associated with polycystic ovary syndrome

Медицинский совет, 2015
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age associated with hyperandrogenism, anovulatory infertility and metabolic disorders.
G. E. Chernukha, E. K. Kaprina, A. A. Naidukova   +2 more
doaj   +1 more source

Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus

MedComm, 2021
Diet‐induced obesity, the metabolic syndrome, type 2 diabetes (DIO/MetS/T2DM), and their adverse sequelae have reached pandemic levels. In mice, DIO/MetS/T2DM initiation involves diet‐dependent increases in lipids that activate hepatic atypical PKC (aPKC)
Mini P. Sajan, Barbara C. Hansen, Mildred Acevedo‐Duncan, Mark S. Kindy, Denise R. Cooper, Robert V. Farese   +5 more
doaj   +1 more source

Hypertriglyceridemia in equines with refractory hyperinsulinemia treated with SGLT2 inhibitors

Open Veterinary Journal, 2023
Background: Sodium-Glucose CoTransporter-2 [SGLT2] inhibitors, the -flozin group of drugs, which block glucose reuptake in the renal proximal tubule, are being increasingly used off-label to treat horses with refractory hyperinsulinemia. After two years
Eleanor M. Kellon, Kathleen M. Gustafson
doaj   +1 more source

Aldosterone status associates with insulin resistance in patients with heart failure-data from the ALOFT study [PDF]

, 2009
<b>Background</b>: Aldosterone plays a key role in the pathophysiology of heart failure. In around 50% of such patients, aldosterone 'escapes' from inhibition by drugs that interrupt the renin-angiotensin axis; such patients have a worse ...
Connell, J.M.C., Freel, E.M., Latini, R., Lewsey, J.D., Maggioni, A.P., McMurray, J.J.V., Pitt, B., Solomon, S., Tsorlalis, I.K.   +8 more
core   +1 more source

High Prevalence of Insulin Resistance in Asymptomatic Patients with Acute Intermittent Porphyria and Liver-Targeted Insulin as a Novel Therapeutic Approach

Biomedicines, 2021
Acute porphyria attacks are associated with the strong up-regulation of hepatic heme synthesis and over-production of neurotoxic heme precursors. First-line therapy is based on carbohydrate loading.
Isabel Solares, Laura Izquierdo-Sánchez, Montserrat Morales-Conejo, Daniel Jericó, Francisco Javier Castelbón, Karol Marcela Córdoba, Ana Sampedro, Carlos Lumbreras, María Jesús Moreno-Aliaga, Rafael Enríquez de Salamanca, Pedro Berraondo, Antonio Fontanellas   +11 more
doaj   +1 more source