Results 51 to 60 of about 103,854 (365)

Metformin Can Attenuate Beta-Cell Hypersecretion—Implications for Treatment of Children with Obesity

Metabolites, 2023
In children with obesity, insulin hypersecretion is proposed to precede insulin resistance. We investigated if metformin could be used to attenuate insulin secretion from palmitate-treated isolated islets and its implication for children with obesity ...
Quan Wen, Rasmus Stenlid, Azazul Islam Chowdhury, Iris Ciba, Banu Aydin, Sara Y. Cerenius, Hannes Manell, Anders Forslund, Peter Bergsten   +8 more
doaj   +1 more source

Insulin clearance and the incidence of type 2 diabetes in Hispanics and African Americans: the IRAS Family Study. [PDF]

, 2013
ObjectiveWe aimed to identify factors that are independently associated with the metabolic clearance rate of insulin (MCRI) and to examine the association of MCRI with incident type 2 diabetes in nondiabetic Hispanics and African Americans.Research ...
Anderson, Andrea M, Bergman, Richard N, Goodarzi, Mark O, Haffner, Steven M, Hanley, Anthony J, Lee, C Christine, Lorenzo, Carlos, Norris, Jill M, Rotter, Jerome I, Stefanovski, Darko, Wagenknecht, Lynne E   +10 more
core   +2 more sources

Metformin therapy in a hyperandrogenic anovulatory mutant murine model with polycystic ovarian syndrome characteristics improves oocyte maturity during superovulation

Journal of Ovarian Research, 2011
Background Metformin, an oral biguanide traditionally used for the treatment of type 2 diabetes, is widely used for the management of polycystic ovary syndrome (PCOS)-related anovulation.
Sabatini Mary E, Guo Lankai, Lynch Maureen P, Doyle Joseph O, Lee HoJoon, Rueda Bo R, Styer Aaron K   +6 more
doaj   +1 more source

Effect of diet-induced obesity on protein expression in insulin signalling pathways of skeletal muscle in male Wistar rats [PDF]

, 2012
BACKGROUND: The prevalence of diet-induced obesity is increasing globally, and posing significant health problems for millions of people worldwide. Diet-induced obesity is a major contributor to the global pandemic of type 2 diabetes mellitus.
Abubakari, Abdul-Razak, Fatani, Sameer, Itua, Imose, Naderali, Ebrahim K., Thomas, Cecil, Wong, Christopher   +5 more
core   +2 more sources

Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2)

Diabetes, 2019
Although insulin resistance consistently occurs with type 1 diabetes, its predominant driver is uncertain. We therefore determined the relative contributions of hyperglycemia and iatrogenic hyperinsulinemia to insulin resistance using hyperinsulinemic ...
J. Gregory, T. Smith, J. Slaughter, H. R. Mason, Curtis C. Hughey, Marta S. Smith, Balamurugan Kandasamy, S. Greeley, L. Philipson, R. Naylor, L. Letourneau, N. Abumrad, A. Cherrington, D. Moore   +13 more
semanticscholar   +1 more source

21 hypoglycemia cases with hyperinsulinemia [PDF]

International Journal of Pediatric Endocrinology, 2013
Congenital hyperinsulinemic hypoglycemia (CHI) is the common cause of severe hypoglycemia in infancy. Profound hypoglycemia requires appropriate diagnosis and aggressive treatment to prevent severe and irreversible brain damage. Here we report 21 Japanese hypoglycemia cases with severe hyperinsulinemia.
Akiko Yamamoto, Satsuki Nishigaki, Yasuhiro Naiki, Reiko Horikawa, Kengo Miyashita, Yusuke Mizuno   +5 more
openaire   +2 more sources

Pathophysiology of Prediabetes Hyperinsulinemia and Insulin Resistance in the Cardiovascular System

Biomedicines
Hyperinsulinemia refers to an elevated level of circulating insulin (80 and 100 µU/mL), often leading to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes (T2D).
Ghassan Bkaily, Ashley Jazzar, Amira Abou-Aichi, Danielle Jacques   +3 more
doaj   +1 more source

Obesity-related cognitive impairment: The role of endothelial dysfunction

Neurobiology of Disease, 2019
Obesity is a global pandemic associated with macro- and microvascular endothelial dysfunction. Microvascular endothelial dysfunction has recently emerged as a significant risk factor for the development of cognitive impairment. In this review, we present
Joy Jones Buie, Luke S. Watson, Crystal J. Smith, Catrina Sims-Robinson   +3 more
doaj   +1 more source

Impact of contraception and IVF hormones on metabolic, endocrine, and inflammatory status [PDF]

, 2020
Assisted reproductive technologies (ART) represent commonly utilized management strategies for infertility with multifactorial causes (including genetically predisposed diseases). Amongst ART, in vitro fertilization (IVF) is the most popular.
Barber, Thomas M., Coussa, Ayla, Hassan, Hayder   +2 more
core   +1 more source

SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia

Cancer & Metabolism, 2019
Obesity confers an increased risk and accelerates the progression of multiple tumor types in rodents and humans, including both breast and colon cancer.
Ali R. Nasiri, Marcos R Rodrigues, Zongyu Li, Brooks P. Leitner, R. Perry   +4 more
semanticscholar   +1 more source