Results 51 to 60 of about 105,064 (356)

Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats [PDF]

, 2013
Background: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expression pattern is unclear ...
Csonka, Csaba, Csont, Tamás Bálint, Fekete, Veronika, Ferdinandy, Péter, Gyémánt, Nóra, Kocsis-Fodor, Gabriella, Pipis, Judit, Puskás, László, Szűcs, Gergő, Sárközy, Márta, Zvara, Ágnes   +10 more
core   +3 more sources

Hyperinsulinemia and oxidative stress

Physiological Research, 2002
The aim of the study was to compare the effect of short-term hyperglycemia and short-term hyperinsulinemia on parameters of oxidative stress in Wistar rats. Twenty male rats (aged 3 months, average body weight 325 g) were tested by hyperinsulinemic clamp (100 IU/l) at two different glycemia levels (6 and 12 mmol/l).
P, Kyselová, M, Zourek, Z, Rusavý, L, Trefil, J, Racek   +4 more
openaire   +2 more sources

Androgens impair β-cell function in a mouse model of polycystic ovary syndrome by activating endoplasmic reticulum stress

Endocrine Connections, 2021
Background: Androgens excess results in endoplasmic reticulum (ER) stress, which is an important cause of β cells dysfunction. Here, we investigated the molecular regulation of androgens excess, ER stress, and β-cell function in polycystic ovary syndrome
Bo Zhu, Yumei Chen, Fang Xu, Xiaolu Shen, Xuanyu Chen, Jieqiang Lv, Songying Zhang   +6 more
doaj   +1 more source

Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR–/–and LDLR+/+mice [PDF]

, 2017
© 2017 The Authors. Immunity, Inflammation and Disease Published by John Wiley & Sons Ltd. INTRODUCTION: Fatty liver disease is prevalent in populations with high caloric intake.
Asai, Baldock, Bieghs, Bora, Cani, Chan, Chawla, Del Ben, DeLuca, Dongiovanni, Drewnowski, George, Giugliano, Glaros, Hummasti, Iwaki, Jorde, Jump, Kalra, Karbowska, Kennedy, Kheder, Kitson, Kleiner, Kraakman, Lira, Livak, Lytle, Machado, Madar, Marcotorchino, Merat, Minto, Oh, Okamoto, Parekh, Pham, Roth, Saraswathi, Schwen, Sergeev, Shu, Subramanian, Teramoto, Tintut, Vanlint, Wortsman, Wouters, Yin, Zhang, Zhang   +50 more
core   +1 more source

Increased Insulin Concentrations During Growth Hormone Treatment in Girls With Turner Syndrome Are Ameliorated by Hormone Replacement Therapy

Frontiers in Endocrinology, 2020
ObjectiveTurner syndrome (TS) is characterized by complete or partial loss of one sex chromosome and is commonly associated with short stature, metabolic changes (such as central obesity, abnormal glucose tolerance and high triglycerides) and premature ...
Sabine Elisabeth Segerer, Stephan Georg Segerer, Carl-Joachim Partsch, Wolfgang Becker, Frank Nawroth   +4 more
doaj   +1 more source

Effect of diet-induced obesity on protein expression in insulin signalling pathways of skeletal muscle in male Wistar rats [PDF]

, 2012
BACKGROUND: The prevalence of diet-induced obesity is increasing globally, and posing significant health problems for millions of people worldwide. Diet-induced obesity is a major contributor to the global pandemic of type 2 diabetes mellitus.
Abubakari, Abdul-Razak, Fatani, Sameer, Itua, Imose, Naderali, Ebrahim K., Thomas, Cecil, Wong, Christopher   +5 more
core   +2 more sources

Metformin therapy in a hyperandrogenic anovulatory mutant murine model with polycystic ovarian syndrome characteristics improves oocyte maturity during superovulation

Journal of Ovarian Research, 2011
Background Metformin, an oral biguanide traditionally used for the treatment of type 2 diabetes, is widely used for the management of polycystic ovary syndrome (PCOS)-related anovulation.
Sabatini Mary E, Guo Lankai, Lynch Maureen P, Doyle Joseph O, Lee HoJoon, Rueda Bo R, Styer Aaron K   +6 more
doaj   +1 more source

Insulin clearance and the incidence of type 2 diabetes in Hispanics and African Americans: the IRAS Family Study. [PDF]

, 2013
ObjectiveWe aimed to identify factors that are independently associated with the metabolic clearance rate of insulin (MCRI) and to examine the association of MCRI with incident type 2 diabetes in nondiabetic Hispanics and African Americans.Research ...
Anderson, Andrea M, Bergman, Richard N, Goodarzi, Mark O, Haffner, Steven M, Hanley, Anthony J, Lee, C Christine, Lorenzo, Carlos, Norris, Jill M, Rotter, Jerome I, Stefanovski, Darko, Wagenknecht, Lynne E   +10 more
core   +2 more sources

SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia

Cancer & Metabolism, 2019
Obesity confers an increased risk and accelerates the progression of multiple tumor types in rodents and humans, including both breast and colon cancer.
Ali R. Nasiri, Marcos R Rodrigues, Zongyu Li, Brooks P. Leitner, R. Perry   +4 more
semanticscholar   +1 more source

21 hypoglycemia cases with hyperinsulinemia [PDF]

International Journal of Pediatric Endocrinology, 2013
Congenital hyperinsulinemic hypoglycemia (CHI) is the common cause of severe hypoglycemia in infancy. Profound hypoglycemia requires appropriate diagnosis and aggressive treatment to prevent severe and irreversible brain damage. Here we report 21 Japanese hypoglycemia cases with severe hyperinsulinemia.
Akiko Yamamoto, Satsuki Nishigaki, Yasuhiro Naiki, Reiko Horikawa, Kengo Miyashita, Yusuke Mizuno   +5 more
openaire   +2 more sources