Results 71 to 80 of about 4,983 (216)

Phthalate and gallstones: the mediation of insulin

Frontiers in Public Health
BackgroundExposure to a mixture of environmental chemicals may cause gallstone, but the evidence remains equivocal. The current study aims to investigate the association between phthalate metabolites and gallstones, and to explore their mediators ...
Haoxian Tang, Haoxian Tang, Xuan Zhang, Xuan Zhang, Jingtao Huang, Jingtao Huang, Nan Luo, Nan Luo, Hongyu Chen, Hongyu Chen, Qinglong Yang, Qinglong Yang, Hanyuan Lin, Hanyuan Lin, Hao Hua   +14 more
doaj   +1 more source

Androgens impair β-cell function in a mouse model of polycystic ovary syndrome by activating endoplasmic reticulum stress

Endocrine Connections, 2021
Background: Androgens excess results in endoplasmic reticulum (ER) stress, which is an important cause of β cells dysfunction. Here, we investigated the molecular regulation of androgens excess, ER stress, and β-cell function in polycystic ovary syndrome
Bo Zhu, Yumei Chen, Fang Xu, Xiaolu Shen, Xuanyu Chen, Jieqiang Lv, Songying Zhang   +6 more
doaj   +1 more source

Preoperative Glycosylated Hemoglobin A1C Impacts Long‐Term Outcomes Following Curative‐Intent Resection of Nonfunctional Gastroenteropancreatic Neuroendocrine Tumors

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background To investigate the impact of preoperative glycosylated hemoglobin A1C (HbA1c) among patients following curative‐intent resection of nonfunctional gastroentropancreatic neuroendocrine tumors (GEP‐NETs). Methods Patients who underwent curative‐intent resection for GEP‐NETs from 2000 to 2020 were identified from the US Neuroendocrine ...
Mu‐Xing Li, Alexandra G. Lopez‐Aguiar, George Poultsides, Flavio Rocha, Sharon Weber, Ryan Fields, Kamran Idrees, Cliff Cho, Shishir K. Maithel, Xu‐Feng Zhang, Timothy M. Pawlik   +10 more
wiley   +1 more source

Aging Reduces Insulin Clearance in Mice

Frontiers in Endocrinology, 2021
Hyperinsulinemia is frequently associated with aging and may cause insulin resistance in elderly. Since insulin secretion and clearance decline with age, hyperinsulinemia seems to be maintained, primarily, due to a decrease in the insulin clearance.
Carine Marmentini, Gabriela M. Soares, Gabriela A. Bronczek, Silvano Piovan, Cecília E. Mareze-Costa, Everardo M. Carneiro, Antonio C. Boschero, Mirian A. Kurauti, Mirian A. Kurauti   +8 more
doaj   +1 more source

GCKR Polymorphisms Increase the Risks of Low Bone Mineral Density in Young and Non‐Obese Patients With MASLD and Hyperuricemia

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic‐associated steatotic liver disease (MASLD) encompasses common comorbidities including low bone mineral density (BMD) and hyperuricemia (HU), yet relevant genetic analyses are limited. This study aimed to investigate the genetic effects of risk single nucleotide polymorphisms (SNPs) on the occurrence of low BMD in patients with MASLD ...
Tzu‐Hao Li, Yu‐Shin Huang, Chia‐Chen Ma, Shin‐Yu Tsai, Hung‐Cheng Tsai, Hsiao‐Yun Yeh, Hsiao‐Chin Shen, Shiao‐Ya Hong, Chien‐Wei Su, Hwai‐I Yang, Ying‐Ying Yang, Ming‐Chih Hou   +11 more
wiley   +1 more source

METABOLIC SYNDROME X - PANDEMIC OF THE XXI CENTURY [PDF]

Саратовский научно-медицинский журнал, 2008
A survey of data found in scientific articles including the main points, structure, spreading and social importance of metabolic syndrome X as a real predictor of mortality level are presented.
Т.D. Kolopkova, V.V. Blinova, Yu.l. Skvortsov, V.G. Subbotina   +3 more
doaj  

A multi-center study on glucometabolic response to bariatric surgery for different subtypes of obesity

Frontiers in Endocrinology, 2022
ObjectivesTo assess the benefit of a bariatric surgery in four artificial intelligence-identified metabolic (AIM) subtypes of obesity with respect to the improvement of glucometabolism and the remission of diabetes and hyperinsulinemia.MethodsThis ...
Yao Liu, Chunjun Sheng, Wenhuan Feng, Fang Sun, Jingjing Zhang, Jingjing Zhang, Ying Chen, Lili Su, Jia Liu, Lei Du, Xuyang Jia, Hui You, Xiu Huang, Shandong Wu, Shandong Wu, Shandong Wu, Ziwei Lin, Shen Qu   +17 more
doaj   +1 more source

Dihydromyricetin Promotes Glucagon‐Like Peptide‐1 Secretion and Improves Insulin Resistance by Modulation of the Gut Microbiota‐CDCA Pathway

Molecular Nutrition &Food Research, EarlyView.
Dihydromyricetin (DHM) administration improved insulin resistance in HFD‐induced mice through the increased serum GLP‐1 level. This benefits was mediated by the decreased degradation of GLP‐1 associated with the reduced proportion of TCRαβ+ CD8αβ+ IELs and decreased expression of CD26/DPP‐4 in IELs, as well as the increased GLP‐1 secretion by ...
Pengfei Li, Yong Zhang, Hedong Lang, Pengfei Hou, Yu Yao, Ruiliang Zhang, Xiaolan Wang, Qianyong Zhang, Mantian Mi, Long Yi   +9 more
wiley   +1 more source

Analysis of beta-cell maturity and mitochondrial morphology in juvenile non-human primates exposed to maternal Western-style diet during development

Frontiers in Endocrinology
IntroductionUsing a non-human primate (NHP) model of maternal Western-style diet (mWSD) feeding during pregnancy and lactation, we previously reported altered offspring beta:alpha cell ratio in vivo and insulin hyper-secretion ex vivo.
Darian T. Carroll, Allie Miller, Jennifer Fuhr, Jennifer Fuhr, Joseph M. Elsakr, Valerie Ricciardi, Alexa N. Del Bene, Stedman Stephens, Evan Krystofiak, Sarah R. Lindsley, Melissa Kirigiti, Diana L. Takahashi, Tyler A. Dean, Stephanie R. Wesolowski, Carrie E. McCurdy, Jacob E. Friedman, Kjersti M. Aagaard, Paul Kievit, Maureen Gannon, Maureen Gannon, Maureen Gannon, Maureen Gannon   +21 more
doaj   +1 more source

Excess Fructose Intake Activates Hyperinsulinemia and Mitogenic MAPK Pathways in Association With Cellular Stress, Inflammation, and Apoptosis in the Pancreas of Rats

Molecular Nutrition &Food Research, EarlyView.
This study highlights the possible mechanisms underlying the detrimental effects of high‐fructose consumption on pancreatic function. Our findings revealed that dietary high‐fructose in the pancreas causes hyperinsulinemia due to the upregulation of glucose transporter 2 (GLUT2) together with cellular stress and inflammatory markers, thereby stimulates
Ceren Guney, Mehmet Eray Alcigir, Fatma Akar   +2 more
wiley   +1 more source