Results 81 to 90 of about 89,537 (288)

Intersection between metabolic dysfunction, high fat diet consumption, and brain aging [PDF]

, 2010
Deleterious neurochemical, structural, and behavioral alterations are a seemingly unavoidable aspect of brain aging. However, the basis for these alterations, as well as the basis for the tremendous variability in regards to the degree to which these ...
Adami, Adams, Adelman, Aguero-Torres, Ahima, Ahren, Akomolafe, Antuna-Puente, Arribas, Arvanitakis, Arvanitakis, Astrup, Bannon, Baran, Barber, Bartus, Barzilai, Baumbach, Baumbach, Baumbach, Behrendt, Bellinger, Berlett, Bertoni-Freddari, Bertoni-Freddari, Bertoni-Freddari, Bertoni-Freddari, Bjorntorp, Blander, Boden, Bolton, Bordone, Bordone, Brandes, Braun, Bravo, Broughton, Bruce-Keller, Buettner, Bugalho, Bullo, Cai, Calabrese, Calabrese, Calabrese, Calabrese, Calabrese, Carlsson, Carr, Cecarini, Cefalu, Cefalu, Chen, Chen, Chen, Clark, Clayton, Clayton, Comfort, Coon, Coyle, Coyle, Craft, Craft, Curb, Damjanovic, De Feo, de la Torre, Dechenes, DeFronzo, DeFronzo, DeKosky, Desai, Ding, Diniz, Droge, Dunn, d’Alessio, Eckles-Smith, Elahi, Elias, Elias, Elias, Fagot-Campagna, Fantuzzi, Farr, Fassbender, Ferrannini, Ferrannini, Ferrannini, Festa, Finch, Finkel, Franceschi, Freund, Fridlyand, Friedman, Frohman, Frolich, Fruhbeck, Fujimoto, Furukawa, Gabbita, Gabriely, Gazzaley, Gemma, Gibson, Gibson, Giunta, Gold, Gonzalez, Good, Granholm, Gray, Greenwood, Griffin, Gunning-Dixon, Gupta, Guttmann, Haan, Handschin, Harvey, Haslam, Heistad, Heitner, Ho, Hosokawa, Howard, Hoyer, Hsu, Hu, Hultsch, Hynd, Iqbal, Itateyama, Iyo, Izumi, James, Jankowsky, Janson, Jia, Joseph, Juhan-Vague, Kaasinen, Kanoski, Kennedy, Kirwan, Kissebah, Kitani, Klann, Klann, Knapp, Koenig, Kuk, Kumar, Kumari, Kuo, Kuriyama, Kuriyama, Laakso, Lamarche, Langan, Lau, Launer, Lee, Leibson, Leone, Lesser, Li, Lippa, Luchsinger, MacKnight, Magnusson, Maier, Manev, Mantena, Massaad, Matia, Matsuzawa-Nagata, Mattson, Mattson, Mattson, Mattson, McClearn, McNay, McNay, Medawar, Mendall, Meng, Messier, Michikawa, Miller, Miller, Milne, Moller, Moreira, Morin, Morrison, Muckle, Nag, Nagai, Navarro, Newton, Nielsen, Nisoli, Nunomura, Nyberg, Oakes, Ogawa, Oomura, Osmond, Ott, O’Shaughnessy, Pacini, Paolisso, Park, Partridge, Pasinetti, Pasinetti, Patterson, Pedigo, Peila, Peiris, Perlmuter, Perry, Perry, Petrovitch, Pfluger, Picard, Pinteaux, Pistell, Qiu, Qu, Rasouli, Razay, Rinne, Rizza, Rizza, Robertson-Tchabo, Roher, Roman, Rosamond, Rowe, Sattler, Sayre, Scacchi, Scheff, Schmitt-Schillig, Shen, Shi, Shimokata, Smith, Smith, Smith, Sohal, Sonntag, Souza, Spulber, Stadtman, Stadtman, Steemburgo, Steen, Strauss, Svedberg, Tanner, Tariot, Taylor, Terao, Terao, Terry, Tha, Thiels, Thiels, Tohgi, Tschop, Urakawa, Uz, van der Heide, van Exel, Vannucchi, Volkow, Wahrenberg, Wang, Wang, Wang, Ward, Wenk, White, Wieringa, Williams, Winocur, Wong, Woods, Wu, Wu, Xiao, Yaffe, Yasui, Ye, Yudkin, Zhang, Zhao, Zlokovic   +302 more
core   +1 more source

Circulating Profiles of the Bile Acid Metabolomics in Patients With Polycystic Ovary Syndrome Treated With Metformin or Canagliflozin

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
ABSTRACT Objective Bile acids are indispensable modulators in the development of polycystic ovary syndrome (PCOS). Our previous study identified that metformin and canagliflozin have similar efficacy in patients with PCOS combined with insulin resistance (IR).
Qi Yan, Meili Cai, Nan Wang, Wenhao Wu, Hua Zhang, Yikun Zhu, Jing Luo, Manna Zhang, Jin Li   +8 more
wiley   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

The Relation of Obesity-Related Hormonal and Cytokine Levels With Multiple Myeloma and Non-Hodgkin Lymphoma

Frontiers in Oncology, 2018
This article presents the first detailed overview of the mechanisms that may underlie the relation of obesity with B-cell non-Hodgkin lymphomas (NHLs) and multiple myeloma (MM).
H. Dean Hosgood, Marc J. Gunter, Neil Murphy, Thomas E. Rohan, Howard D. Strickler   +4 more
doaj   +1 more source

Effects of long-term soluble vs. insoluble dietary fiber intake on high-fat diet-induced obesity in C57BL/6J mice [PDF]

, 2010
Although most of the proposed beneficial effects of fiber consumption have been attributed to viscous and gel-forming properties of soluble fiber, it is mainly insoluble cereal fiber and whole grains that are strongly associated with reduced diabetes ...
Andreas F.H. Pfeiffer, Backhed, Cameron-Smith, Covington, de Munter, Frank Isken, Galisteo, Hong, Howarth, Isken, Jenkins, Jenkins, King, Kumar, Liese, Martin O. Weickert, Martin Osterhoff, McNeil, Owusu-Asiedu, Pereira, Pittler, Ristow, Robertson, Robertson, Schulze, Song, Steneberg, Stewart, Susanne Klaus, Thorburn, Track, Weickert, Weickert, Weickert, Weickert, Wolfrum, Wolfrum   +36 more
core   +1 more source

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source

Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski, Mahima Raju, Tracy Fitzsimmons, Ishraq Murshed, Timothy J. Price, Michael Penniment, Sudarsha Selva‐Nayagam, Tarik Sammour   +7 more
wiley   +1 more source

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice [PDF]

, 2003
Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension.
Aubert, Busetto, Butz, Christopher J. Kenyon, Contreras, Cowley, De la Sieera, Folli, Frederich, Hiroaki Masuzaki, Hiroshi Shinyama, Hiroshi Yamamoto, Janice M. Paterson, Jeffrey S. Flier, Joel K. Elmquist, John J. Mullins, Johnson, Jonathan R. Seckl, Kopelman, Lalouel, Llorens-Cortes, Massiera, Masuzaki, Matthew G.F. Sharp, Miller, Mills, Montani, Morton, Nicholas M. Morton, O’Brien, Pradevand, Pratt, Rotimi, Stepp, Stewart Fleming, Villiquette, Walker, Weinburger, Williams, Yamamoto   +39 more
core   +6 more sources

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, EarlyView.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Gene-environment interaction modifies the association between hyperinsulinemia and serum urate levels through SLC22A12

The Journal of Clinical Investigation
BACKGROUND Hyperinsulinemia and insulin resistance often accompany elevated serum urate levels (hyperuricemia), a highly heritable condition that triggers gout; however, the underlying mechanisms are unclear.METHODS We evaluated the association between ...
Wataru Fujii, Osamu Yamazaki, Daigoro Hirohama, Ken Kaseda, Emiko Kuribayashi-Okuma, Motonori Tsuji, Makoto Hosoyamada, Yuta Kochi, Shigeru Shibata   +8 more
doaj   +1 more source