Results 51 to 60 of about 20,887 (300)

Congenital Hyperinsulinism

Contemporary endocrinology, 2020
Congenital hyperinsulinism (CHI or HI) is a condition leading to recurrent hypoglycemia due to an inappropriate insulin secretion by the pancreatic islet beta cells.
J. Arnoux, Pascale de Lonlay, Maria Ribeiro, Khalid Hussain, Oliver Blankenstein, Klaus Mohnike, V. Valayannopoulos, Jean-Jacques Robert, J. Rahier, Christine Sempoux, Christine Bellanné, Virginie Verkarre, Yves Aigrain, F. Jaubert, Francis Brunelle, Claire Nihoul-Fékété   +15 more
semanticscholar   +1 more source

Modern therapeutic aspects in two cases of congenital hyperinsulinism [PDF]

Romanian Journal of Pediatrics, 2020
In this article we will present the therapeutic and clinical aspects found in the case of two pediatric patients diagnosed with congenital hyperinsulinism.
Cristian Minulescu, Dana Spirea
doaj   +1 more source

Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells [PDF]

, 2017
ATP-sensitive potassium channels (K(ATP) channels) are critical nutrient sensors in many mammalian tissues. In the pancreas, K(ATP) channels are essential for coupling glucose metabolism to insulin secretion.
Conway, Hannah, Emfinger, Christopher H., Moss, Jennifer B., Moss, Larry G., Nichols, Colin G., Remedi, Maria S., Wang, Yixi, Welscher, Alecia, Yan, Zihan   +8 more
core   +2 more sources

18F-6-Fluoro-l-Dopa PET/CT Imaging of Congenital Hyperinsulinism.

Journal of Nuclear Medicine, 2021
Congenital hyperinsulinism is characterized by persistent hypoglycemia due to inappropriate excess secretion of insulin resulting in hyperinsulinemic hypoglycemia.
L. States, J. C. Davis, Steven M Hamel, Susan A. Becker, H. Zhuang   +4 more
semanticscholar   +1 more source

Tissue Sodium Content and Arterial Hypertension in Obese Adolescents [PDF]

, 2019
Early-onset obesity is known to culminate in type 2 diabetes, arterial hypertension and subsequent cardiovascular disease. The role of sodium (Na+) homeostasis in this process is incompletely understood, yet correlations between Na+ accumulation and ...
Berger, Felix, Birukov, Anna, Ghorbani, Niky, Hennemuth, Anja, Jones, Alexander, Kelm, Marcus, Kuehne, Titus, Kühnen, Peter, Linz, Peter, Markó, Lajos, Müller, Dominik N., Roth, Sophie, Wiegand, Susanna   +12 more
core   +3 more sources

Pasireotide treatment for severe congenital hyperinsulinism due to a homozygous ABCC8 mutation

Annals of Pediatric Endocrinology & Metabolism, 2021
ABCC8 and KCJN11 mutations cause the most severe diazoxide-resistant forms of congenital hyperinsulinism (CHI). Somatostatin analogues are considered as secondline treatment in diazoxide-unresponsive cases.
C. Mooij, C. Tacke, M. V. van Albada, W. Barthlen, H. Bikker, K. Mohnike, M. Oomen, A. S. V. van Trotsenburg, N. Zwaveling-Soonawala   +8 more
semanticscholar   +1 more source

Neonatal Hyperinsulinism [PDF]

Trends in Endocrinology & Metabolism, 1999
Hypoglycemia as a result of hyperinsulinism in the newborn (HI) is a clinically heterogeneous entity that presents a diagnostic and therapeutic challenge to the treating physician. Recent discoveries have shown that mutations in four different beta-cell genes cause HI.
, Glaser, , Landau, , Permutt
openaire   +4 more sources

Update of variants identified in the pancreatic β‐cell KATP channel genes KCNJ11 and ABCC8 in individuals with congenital hyperinsulinism and diabetes

Human Mutation, 2020
The most common genetic cause of neonatal diabetes and hyperinsulinism is pathogenic variants in ABCC8 and KCNJ11. These genes encode the subunits of the β‐cell ATP‐sensitive potassium channel, a key component of the glucose‐stimulated insulin secretion ...
E. De Franco, C. Saint-Martin, K. Brusgaard, Amy E. Knight Johnson, Lydia Aguilar-Bryan, Pamela Bowman, J. Arnoux, Annette Rønholt Larsen, May Sanyoura, S. A. Greeley, Raúl Calzada-León, Bradley Harman, J. Houghton, Elisa Nishimura-Meguro, T. Laver, Sian Ellard, D. del Gaudio, Henrik Thybo Christesen, C. Bellanné-Chantelot, Sarah E Flanagan   +19 more
semanticscholar   +1 more source

Activation of Protein Kinase A (PKA) signaling mitigates congenital hyperinsulinism associated hypoglycemia in the Sur1-/- mouse model.

PLoS ONE, 2020
There is a significant unmet need for a safe and effective therapy for the treatment of children with congenital hyperinsulinism. We hypothesized that amplification of the glucagon signaling pathway could ameliorate hyperinsulinism associated ...
Mangala M Soundarapandian, Christine A Juliana, Jinghua Chai, Patrick A Haslett, Kevin Fitzgerald, Diva D De León   +5 more
doaj   +1 more source

Nifedipine in Congenital Hyperinsulinism - A Case Report. [PDF]

, 2016
PublishedJournal ArticleThis is the final version of the article. Available from Galenos Yayınevi via the DOI in this record.Congenital hyperinsulinism (CHI) is the commonest cause of persistent hypoglycemia in neonates.
Basak, D, Chatterjee, S, Flanagan, SE, Hussain, K, Khawash, P   +4 more
core   +1 more source