Results 51 to 60 of about 20,640 (292)
A Multicenter Experience with Long-Acting Somatostatin Analogues in Patients with Congenital Hyperinsulinism [PDF]
, 2017 Background/Aims: Congenital hyperinsulinism (CHI) is a rare disease characterized by recurrent severe hypoglycemia. In the diffuse form of CHI, pharmacotherapy is the preferred choice of treatment.
Banerjee, Indraneel +10 more
core +3 more sources
Neonatal Hyperinsulinism [PDF]
Trends in Endocrinology & Metabolism, 1999 Hypoglycemia as a result of hyperinsulinism in the newborn (HI) is a clinically heterogeneous entity that presents a diagnostic and therapeutic challenge to the treating physician. Recent discoveries have shown that mutations in four different beta-cell genes cause HI.
, Glaser, , Landau, , Permutt
openaire +4 more sources
Frontiers in Endocrinology, 2021 IntroductionDespite improvements in diagnosis and therapeutic advances in treatment, congenital hyperinsulinism (CHI) remains a severe disease with high patient impairment.
Kaja Kristensen +2 more
doaj +1 more source
Human Mutation, 2020 The most common genetic cause of neonatal diabetes and hyperinsulinism is pathogenic variants in ABCC8 and KCNJ11. These genes encode the subunits of the β‐cell ATP‐sensitive potassium channel, a key component of the glucose‐stimulated insulin secretion ...
E. De Franco +19 more
semanticscholar +1 more source
Tissue Sodium Content and Arterial Hypertension in Obese Adolescents [PDF]
, 2019 Early-onset obesity is known to culminate in type 2 diabetes, arterial hypertension and subsequent cardiovascular disease. The role of sodium (Na+) homeostasis in this process is incompletely understood, yet correlations between Na+ accumulation and ...
Berger, Felix +12 more
core +3 more sources
Orphanet Journal of Rare Diseases, 2021 Congenital hyperinsulinism (CHI), a major cause of persistent and recurrent hypoglycemia in infancy and childhood. Numerous pathogenic genes have been associated with 14 known genetic subtypes of CHI.
Wei Zhang, Yan-Mei Sang
doaj +1 more source
Management and appropriate use of diazoxide in infants and children with hyperinsulinism.
Journal of Clinical Endocrinology and Metabolism, 2020 BACKGROUND The diagnosis of hypoglycemia and the use of diazoxide have risen in the last decade. Diazoxide is the only FDA-approved pharmacologic treatment for neonatal hypoglycemia caused by hyperinsulinism (HI).
P. Brar +11 more
semanticscholar +1 more source
Hyperinsulinemic Hypoglycemia and Growth Hormone Deficiency Secondary to 20p11 Deletion
Case Reports in Endocrinology, 2023 Hypoglycemia is concerning for neurological complications in infants and children. Determining the cause of hypoglycemia is essential in providing appropriate treatment.
Erica Wee +5 more
doaj +1 more source
Transient hyperinsulinism in neonates
Problems of Endocrinology, 2020 Congenital hyperinsulinusm is rare disease characterized high secretion of insulin by pancreatic beta cells leading to the development of hypoglycemia. Persistent and transient forms of hyperinsulinism are distinguished. Transient hyperinsulinism are the most common cause of severe hypoglycemia in newborns.
Anna V. Bolmasova +7 more
openaire +4 more sources
Clinical and molecular data from 61 Brazilian cases of Congenital Hyperinsulinemic Hypoglycemia [PDF]
, 2015 Objective: To study the clinical and molecular characteristics of a sample of Brazilian patients with Congenital Hyperinsulinemic Hypoglycemia (CHH).Methods: Electronic message was sent to members from Endocrinology Department-Brazilian Society of ...
Della Manna, Thais +5 more
core +3 more sources