Results 61 to 70 of about 20,887 (300)

Birth weight and diazoxide unresponsiveness strongly predict the likelihood of congenital hyperinsulinism due to a mutation in ABCC8 or KCNJ11

European Journal of Endocrinology, 2021
Objective Mutations in the KATP channel genes, ABCC8 and KCNJ11, are the most common cause of congenital hyperinsulinism. The diagnosis of KATP-hyperinsulinism is important for the clinical management of the condition.
Thomas I. Hewat, D. Yau, Joseph C S Jerome, T. Laver, J. Houghton, B. Shields, S. Flanagan, K. Patel   +7 more
semanticscholar   +1 more source

Clinical and molecular data from 61 Brazilian cases of Congenital Hyperinsulinemic Hypoglycemia [PDF]

, 2015
Objective: To study the clinical and molecular characteristics of a sample of Brazilian patients with Congenital Hyperinsulinemic Hypoglycemia (CHH).Methods: Electronic message was sent to members from Endocrinology Department-Brazilian Society of ...
Della Manna, Thais, Guerra, Gil, Liberatore, Raphael Del Roio, Martinelli Junior, Carlos Eduardo, Ramos, Priscila Manzini, Silva, Ivani Novato   +5 more
core   +3 more sources

Pancreatic endocrine and exocrine function in children following near-total pancreatectomy for diffuse congenital hyperinsulinism. [PDF]

, 2016
Published onlineJournal ArticleCONTEXT: Congenital hyperinsulinism (CHI), the commonest cause of persistent hypoglycaemia, has two main histological subtypes: diffuse and focal.
Alam, S, Arya, VB, Demirbilek, H, Ellard, S, Flanagan, SE, Hussain, K, Senniappan, S   +6 more
core   +1 more source

Transient hyperinsulinism in neonates

Problems of Endocrinology, 2020
Congenital hyperinsulinusm is rare disease characterized high secretion of insulin by pancreatic beta cells leading to the development of hypoglycemia. Persistent and transient forms of hyperinsulinism are distinguished. Transient hyperinsulinism are the most common cause of severe hypoglycemia in newborns.
Anna V. Bolmasova, Maria A. Melikyan, Natalya A. Krylova, Oleg V. Ionov, Irina I. Ryumina, Ekaterina L. Bockeria, Natalya A. Pekareva, Anna V. Degtyareva   +7 more
openaire   +4 more sources

Characterization of the zebrafish as a model of ATP-sensitive potassium channel hyperinsulinism

BMJ Open Diabetes Research & Care
Introduction Congenital hyperinsulinism (HI) is the leading cause of persistent hypoglycemia in infants. Current models to study the most common and severe form of HI resulting from inactivating mutations in the ATP-sensitive potassium channel (KATP) are
Diva D De León, Christine A Juliana, Joshua Benjet   +2 more
doaj   +1 more source

Insulin-induced glycosylphosphatidylinositol (GPI) binding to red cell membrane proteins [PDF]

Journal of the Serbian Chemical Society, 2002
In this work GPI binding to membrane proteins from erythrocytes of insulinoma patients for whom prolonged hyperinsulinism and hypoglycemia were characteristic, as well as from normal erythrocytes incubated with supraphysiological concentrations of ...
NENAD TOMASEVIC, VESNA NIKETIC, MILAN NIKOLIC   +2 more
doaj   +3 more sources

Real-world experience with the use of diazoxide among people living with congenital hyperinsulinism and their caregivers

Frontiers in Endocrinology
IntroductionCongenital hyperinsulinism (HI) is a rare disease that causes severe hypoglycemia. Diazoxide is the first-line treatment; however, many individuals using diazoxide continue to experience hypoglycemia. Diazoxide is associated with side effects
Tai L. S. Pasquini, Kristen E. Rohli, Fiona J. Almeida, Indraneel Banerjee, Antonia Dastamani, Diva D. De Leon, Lauren N. Lopez, Paul S. Thornton, Julie Raskin   +8 more
doaj   +1 more source

Health-Related Quality of Life of Children and Adolescents With Congenital Hyperinsulinism – A Scoping Review

Frontiers in Endocrinology, 2021
IntroductionDespite improvements in diagnosis and therapeutic advances in treatment, congenital hyperinsulinism (CHI) remains a severe disease with high patient impairment.
Kaja Kristensen, Julia Quitmann, Stefanie Witt   +2 more
doaj   +1 more source

A combination of nifedipine and octreotide treatment in an hyperinsulinemic hypoglycemic infant. [PDF]

, 2016
PublishedResearch Support, Non-U.S. Gov'tThis is the final version of the article. Available from Galenos Publishing via the DOI in this record.Hyperinsulinemic hypoglycemia (HH) is the commonest cause of persistent hypoglycemia in the neonatal and ...
Akcurin, S, Bircan, I, Durmaz, E, Ellard, S, Flanagan, SE, Parlak, M   +5 more
core   +1 more source

The Genetic and Molecular Mechanisms of Congenital Hyperinsulinism

Frontiers in Endocrinology, 2019
Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic hypoglycaemia.
S. Galcheva, H. Demirbilek, S. Al-Khawaga, K. Hussain   +3 more
semanticscholar   +1 more source