Results 61 to 70 of about 20,640 (292)

Characterization of the zebrafish as a model of ATP-sensitive potassium channel hyperinsulinism

BMJ Open Diabetes Research & Care
Introduction Congenital hyperinsulinism (HI) is the leading cause of persistent hypoglycemia in infants. Current models to study the most common and severe form of HI resulting from inactivating mutations in the ATP-sensitive potassium channel (KATP) are
Diva D De León, Christine A Juliana, Joshua Benjet   +2 more
doaj   +1 more source

Hyperinsulinism May Be Underreported in Hypoglycemic Patients with Phosphomannomutase 2 Deficiency

JCRPE, 2022
INTRODUCTION: Phosphomannomutase 2 deficiency (PMM2-CDG) is a disorder of protein N-glycosylation with a wide clinical spectrum. Hypoglycemia is rarely reported in PMM2-CDG.
Doğuş Vurallı, Yılmaz Yıldız, Alev Ozon, Ali Dursun, Nazlı Gönç, Ayşegül Tokatlı, H. Serap Sivri, Ayfer Alikaşifoğlu   +7 more
doaj   +1 more source

Nifedipine in Congenital Hyperinsulinism - A Case Report. [PDF]

, 2016
PublishedJournal ArticleThis is the final version of the article. Available from Galenos Yayınevi via the DOI in this record.Congenital hyperinsulinism (CHI) is the commonest cause of persistent hypoglycemia in neonates.
Basak, D, Chatterjee, S, Flanagan, SE, Hussain, K, Khawash, P   +4 more
core   +1 more source

The Genetic and Molecular Mechanisms of Congenital Hyperinsulinism

Frontiers in Endocrinology, 2019
Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic hypoglycaemia.
S. Galcheva, H. Demirbilek, S. Al-Khawaga, K. Hussain   +3 more
semanticscholar   +1 more source

Pancreatic endocrine and exocrine function in children following near-total pancreatectomy for diffuse congenital hyperinsulinism. [PDF]

, 2016
Published onlineJournal ArticleCONTEXT: Congenital hyperinsulinism (CHI), the commonest cause of persistent hypoglycaemia, has two main histological subtypes: diffuse and focal.
Alam, S, Arya, VB, Demirbilek, H, Ellard, S, Flanagan, SE, Hussain, K, Senniappan, S   +6 more
core   +1 more source

Arterial Calcium Stimulation with Hepatic Venous Sampling in the Localization Diagnosis of Endogenous Hyperinsulinism

International Journal of Endocrinology, 2016
Objective. The aim of this study was to assess the utility of arterial calcium stimulation with hepatic venous sampling (ASVS) in the localization diagnosis of endogenous hyperinsulinism. Patients and Methods.
Paloma Moreno-Moreno, María Rosa Alhambra-Expósito, Aura Dulcinea Herrera-Martínez, Rafel Palomares-Ortega, Luis Zurera-Tendero, Juan José Espejo Herrero, María Angeles Gálvez-Moreno   +6 more
doaj   +1 more source

Hypoglycemia: varieties of etiopathogenesis and clinic. Observations from practice

Mìžnarodnij Endokrinologìčnij Žurnal, 2022
Hypoglycemic syndrome is often noted in clinical practice in the treatment of patients with diabetes mellitus (DM), especially with insulin. This syndrome is manifested by symptoms caused by neuroglycopenia (insufficient supply of glucose to the brain ...
P.M. Lіashuk, R.P. Lіashuk, Yu.F. Marchuk, N.I. Stankova, M.B. Kudina   +4 more
doaj   +1 more source

Using referral rates for genetic testing to determine the incidence of a rare disease: The minimal incidence of congenital hyperinsulinism in the UK is 1 in 28,389

PLoS ONE, 2020
Congenital hyperinsulinism (CHI) is a significant cause of hypoglycaemia in neonates and infants with the potential for permanent neurologic injury. Accurate calculations of the incidence of rare diseases such as CHI are important as they inform health ...
D. Yau, T. Laver, A. Dastamani, S. Senniappan, J. Houghton, G. Shaikh, T. Cheetham, T. Mushtaq, R. Kapoor, T. Randell, S. Ellard, P. Shah, I. Banerjee, S. Flanagan   +13 more
semanticscholar   +1 more source

Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations [PDF]

, 2011
Dominantly acting loss-of-function mutations in the ABCC8/KCNJ11 genes can cause mild medically responsive hyperinsulinaemic hypoglycaemia (HH). As controversy exists over whether these mutations predispose to diabetes in adulthood we investigated the ...
Ellard, S, Flanagan, SE, Harmer, SC, Hussain, K, James, CT, Kapoor, RR, McKiernan, J, Shield, JP, Thomas, AM, Tinker, A   +9 more
core   +4 more sources

Risk Factors for Adverse Neurodevelopment in Transient or Persistent Congenital Hyperinsulinism

Frontiers in Endocrinology, 2020
Objective Aim was to identify hypotheses why adverse neurodevelopment still occurs in children with transient or persistent hyperinsulinism despite improvements in long-term treatment options during the last decades.
Marcia Roeper, Roschan Salimi Dafsari, Henrike Hoermann, E. Mayatepek, S. Kummer, T. Meissner   +5 more
semanticscholar   +1 more source