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Hypermethylation in gastric cancer
Clinica Chimica Acta, 2015Although gastric cancer (GC) is highly prevalent in China and is a leading cause of cancer-related death, major advances in early diagnostic and effective therapeutic strategies have not been made. GC patients are usually diagnosed at an advanced stage and the prognosis is still poor.
Yujun, Li, Junrong, Liang, Peng, Hou
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Hypermethylation and Carcinogenesis
Science, 2002In cancer cells, abnormal methylation patterns of DNA sequences are often present. By examining the role of the PML-RAR fusion gene, a well-studied translocation in leukemia, Di Croce et al . demonstrate that transcriptional silencing in cancer cells can occur through the ...
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Hypermethylation of E-cadherin in leukemia
Blood, 2000E-cadherin gene is often termed a “metastasis suppressor” gene because the E-cadherin protein can suppress tumor cell invasion and metastasis. Inactivation of the E-cadherin gene occurs in undifferentiated solid tumors by both genetic and epigenetic mechanisms; however, the role of E-cadherin in hematologic malignancies is only now being recognized.
J R, Melki +3 more
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Clustering of hypermethylated genes in neuroblastoma
Genes, Chromosomes and Cancer, 2003AbstractCpG‐island hypermethylation of gene promoters is a frequent mechanism for gene inactivation in tumors. Many neuroblastomas have hypermethylation and down‐regulation of CASP8, leading to resistance to tumor necrosis factor–related apoptosis‐inducing ligand (TRAIL). We recently found hypermethylation of the four TRAIL receptors in 9 neuroblastoma
van Noesel, Max M. +5 more
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DNA hypermethylation in gastric cancer
Alimentary Pharmacology & Therapeutics, 2004SummaryBackground : Transcriptional silencing of tumour suppressor genes by DNA hypermethylation plays a crucial role in the progression of gastric cancer. Many genes involved in the regulation of cell cycle, tissue invasion, DNA repair and apoptosis have been shown to be inactivated by this type of epigenetic mechanism.Results : Recent studies have ...
T Y, Kim +5 more
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Role of Hypermethylation on Carcinogenesis in the Pancreas
Surgery Today, 2004Pancreatic cancer is a disease with a dismal outcome and a 5-year survival rate of under 5%. Recent studies have shown that pancreatic cancer consists of an accumulation of genetic and epigenetic alterations during tumor development as in other human cancers.
Tamotsu, Kuroki +2 more
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The Hypermethylated Regions in Avian Chromosomes
Cytogenetic and Genome Research, 2017Chromosomal locations and amounts of 5-methylcytosine-rich chromosome regions were detected in the karyotypes of 13 bird species by indirect immunofluorescence using a monoclonal anti-5-methylcytosine antibody. These species belong to 7 orders and 10 families of modern (Neognathae) and primitive (Palaeognathae) birds and are characterized by macro- and
Michael, Schmid, Claus, Steinlein
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Hypermethylation of the RASSF1A gene in gliomas
Clinica Chimica Acta, 2004Promoter methylation is an important pathway in transcriptional silencing of tumor suppressor genes (TSGs) in brain tumors. The identified 3p21.3 tumor suppressor gene RAS association domain family protein 1A (RASSF1A) is highly methylated in primary lung, breast and other tumors.
Yunxia, Gao +5 more
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DNA hypermethylation as a chemotherapy target
Cellular Signalling, 2011Epigenetics refers to partially reversible, somatically inheritable, but DNA sequence-independent traits that modulate gene expression, chromatin structure, and cell functions such as cell cycle and apoptosis. DNA methylation is an example of a crucial epigenetic event; aberrant DNA methylation patterns are frequently found in human malignancies.
Juan, Ren +9 more
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