Results 71 to 80 of about 3,251 (194)

Proteome‐Wide Mendelian Randomization Identifies Candidate Causal Proteins for Cardiovascular Diseases

Advanced Genetics, EarlyView.
Here, causal relations are examined between 2940 plasma proteins and 19 cardiovascular diseases (CVD) using a human genetics‐based method. 218 proteins are found whose blood levels influence CVD risks, with about half being new discoveries and largely confirmed in an independent cohort.
Chen Li, Nicolas De Jay, Shan‐Shan Zhang, Xin Fang, Supriya Sharma, Katrina A. Catalano, Venkatesh Sridharan, Zhaoqing Wang, Lei Zhao, Joseph D. Szustakowski, Ching‐Pin Chang, Joseph C. Maranville, Emily R. Holzinger, Erika M. Kvikstad   +13 more
wiley   +1 more source

Biology of portal hypertension [PDF]

Hepatology International, 2017
Portal hypertension develops as a result of increased intrahepatic vascular resistance often caused by chronic liver disease that leads to structural distortion by fibrosis, microvascular thrombosis, dysfunction of liver sinusoidal endothelial cells (LSECs), and hepatic stellate cell (HSC) activation.
Matthew McConnell, Yasuko Iwakiri
openaire   +3 more sources

Involvement of serum apolipoprotein AI and B100 and lecithin cholesterol acyl transferase in alcoholic cirrhotics

Annals of Hepatology, 2007
Lipoproteins are synthesized by the liver and secreted to plasma. Chronic alcoholic intoxication produces frequently cirrhosis and concomitantly alterations in liver metabolism.
Abraham Lemberg, Laura Schreier, Salvador Romay, Maria Alejandra Fernández, Diego Rosello, Soledad Gonzales, Juan Carlos Perazzo, Ester Julia Filinger, Maria Lujan Tomaro   +8 more
doaj  

Portal hypertension is associated with modulation of regulatory T cells

European Journal of Inflammation, 2016
Background: Portal hypertension is a complication of liver cirrhosis. The portal vein drains the spleen and the intestines, which are both rich in inflammatory mediators.
Tomer Adar, Yair Edden, Shimon Shteingart, Ami Ben Ya’acov, Mahmud Mahamid, Ellen Broide, Shimrit Shmorak, Ariella Bar-Gil Shitrit, Constantin Reinus, Eran Goldin   +9 more
doaj   +1 more source

Burden of pulmonary hypertension in patients with portal hypertension in the United States: a retrospective database study

Pulmonary Circulation, 2020
Patients with portal hypertension may develop pulmonary hypertension. The economic implications of these comorbidities have not been systematically assessed. We compared healthcare resource utilization and costs in the United States between patients with
Sandeep Sahay, Yuen Tsang, Megan Flynn, Peter Agron, Robert Dufour   +4 more
doaj   +1 more source

Prediction of survival and analysis of prognostic factors for patients with AFP negative hepatocellular carcinoma: a population-based study

BMC Gastroenterology
Purpose Hepatocellular carcinoma (HCC) has a poor prognosis, and alpha-fetoprotein (AFP) is widely used to evaluate HCC. However, the proportion of AFP-negative individuals cannot be disregarded.
Chengyu Liu, Zikang Li, Zhilei Zhang, Jinlong Li, Congxi Xu, Yuming Jia, Chong Zhang, Wuhan Yang, Wenchuan Wang, Xiaojuan Wang, Kuopeng Liang, Li Peng, Jitao Wang   +12 more
doaj   +1 more source

Percutaneous transhepatic portal vein stenting in a patient with benign non-transplant postoperative portal vein stenosis: A case report

Indian Journal of Radiology and Imaging, 2013
Extrahepatic portal vein stenosis is caused by a variety of benign and malignant diseases and results in development of symptoms due to portal hypertension.
KS Madhusudhan, Nikhil Agrawal, Deep N Srivastava, Sujoy Pal, Arun K Gupta   +4 more
doaj   +1 more source

Imaging-guided interventions modulating portal venous flow: Evidence and controversiesKey points

JHEP Reports, 2022
Summary: Portal hypertension is defined by an increase in the portosystemic venous gradient. In most cases, increased resistance to portal blood flow is the initial cause of elevated portal pressure.
Roberto Cannella, Lambros Tselikas, Fréderic Douane, François Cauchy, Pierre-Emmanuel Rautou, Rafael Duran, Maxime Ronot   +6 more
doaj  

Hyperammonemia of unknown origin

Clinical Management Issues, 2015
Idiopathic portal hypertension is a benign long-standing non-cirrhotic portal hypertension with no typical laboratory findings and absence of stigmata of chronic liver disease.
Francesca Molino
doaj   +1 more source

Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapyKey points

JHEP Reports, 2021
Summary: Portal hypertension, defined as increased pressure in the portal vein, develops as a consequence of increased intrahepatic vascular resistance due to the dysregulation of liver sinusoidal endothelial cells (LSECs) and hepatic stellate cells ...
Yasuko Iwakiri, Jonel Trebicka
doaj