Results 51 to 60 of about 2,534,413 (315)

SNPs Filtered by Allele Frequency Improve the Prediction of Hypertension Subtypes [PDF]

arXiv, 2021
Hypertension is the leading global cause of cardiovascular disease and premature death. Distinct hypertension subtypes may vary in their prognoses and require different treatments. An individual's risk for hypertension is determined by genetic and environmental factors as well as their interactions.
arxiv  

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Human Kidney Tubule-Specific Gene Expression Based Dissection of Chronic Kidney Disease Traits

EBioMedicine, 2017
Chronic kidney disease (CKD) has diverse phenotypic manifestations including structural (such as fibrosis) and functional (such as glomerular filtration rate and albuminuria) alterations.
Pazit Beckerman, Chengxiang Qiu, Jihwan Park, Nora Ledo, Yi-An Ko, Ae-Seo Deok Park, Sang-Youb Han, Peter Choi, Matthew Palmer, Katalin Susztak   +9 more
doaj   +1 more source

Difficulty and importance of diagnosing stenosis of renal branch artery in fibromuscular dysplasia: a case report

Blood Pressure, 2021
A 16-year-old patient presented with abdominal pain and sustained hypertension. Thorough evaluation including renography with and without captopril and renal vein renin sampling were normal.
Andreas Skræddergaard, Jakob Nyvad, Kent Lodberg Christensen, Arne Hørlyck, Hossein Mohit Mafi, Mark Reinhard   +5 more
doaj   +1 more source

2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents [PDF]

, 2016
Increasing prevalence of hypertension (HTN) in children and adolescents has become a significant public health issue driving a considerable amount of research.
Agabiti-Rosei, Enrico, Cruickshank, J. Kennedy, Dominiczak, Anna, Erdine, Serap, Hirth, Asle, Invitti, Cecilia, Litwin, Mieczyslaw, Lurbe, Empar, Mancia, Giuseppe, Pall, Denes, Rascher, Wolfgang, Redon, Josep, Schaefer, Franz, Seeman, Tomas, Sinha, Manish, Stabouli, Stella, Webb, Nicholas J., Wühl, Elke, Zanchetti, Alberto   +18 more
core   +1 more source

The Impact of Diabetes and Metabolic Syndrome Burden on Pain, Neuropathy Severity and Fiber Type

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Determine the association between diabetes and metabolic syndrome (MetS) burden (number of MetS criteria fulfilled) and pain, neuropathy severity, and fiber type involvement in individuals with established polyneuropathy. Methods The Peripheral Neuropathy Research Registry was queried for individuals with type 1 and type 2 diabetes ...
Long Davalos, Brian C. Callaghan, Lavanya Muthukumar, Simone Thomas, Evan L. Reynolds, A. Gordon Smith, J. Robinson Singleton, Ahmet Höke, Senda Ajroud‐Driss, Mazen M. Dimachkie, Stefanie Geisler, David M. Simpson, PNRR Study Group, Amro M. Stino   +13 more
wiley   +1 more source

GPAT4-Generated Saturated LPAs Induce Lipotoxicity through Inhibition of Autophagy by Abnormal Formation of Omegasomes

iScience, 2020
Summary: Excessive levels of saturated fatty acids are toxic to vascular smooth muscle cells (VSMCs). We previously reported that mice lacking VSMC-stearoyl-CoA desaturase (SCD), a major enzyme catalyzing the detoxification of saturated fatty acids ...
Yuji Shiozaki, Shinobu Miyazaki–Anzai, Kayo Okamura, Audrey L. Keenan, Masashi Masuda, Makoto Miyazaki   +5 more
doaj  

A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis

Nature Communications, 2021
Identifying causal variants and genes is an essential step in interpreting GWAS loci. Here, the authors investigate a kidney disease GWAS locus with functional genomics data, CRISPR editing and mouse experiments to identify DPEP1 and CHMP1A as putative ...
Yuting Guan, Xiujie Liang, Ziyuan Ma, Hailong Hu, Hongbo Liu, Zhen Miao, Andreas Linkermann, Jacklyn N. Hellwege, Benjamin F. Voight, Katalin Susztak   +9 more
doaj   +1 more source

La alteración de sistemas natriuréticos renales se asocia con el desarrollo de hipertensión arterial y precede en el tiempo a la aparición de daño renal en un modelo de síndrome metabólico [PDF]

, 2018
Objetivos: El objetivo del trabajo consistió en determinar la existencia de alteraciones en los sistemas natriuréticos del péptido natriurético atrial y dopamina renal en un modelo de síndrome metabólico por sobrecarga de fructosa y asociarlas con ...
Choi, Marcelo Roberto, del Mauro, Julieta Sofía, Fernandez, Belisario Enrique, Gironacci, Mariela Mercedes, Kouyoumdzian, Nicolás Martín, Puyó, Ana María, Rukavina Mikusic, Natalia Lucía, Toblli, Jorge Eduardo   +7 more
core   +1 more source

A Multi-Stage Framework for the 2022 Multi-Structure Segmentation for Renal Cancer Treatment [PDF]

arXiv, 2022
Three-dimensional (3D) kidney parsing on computed tomography angiography (CTA) images is of great clinical significance. Automatic segmentation of kidney, renal tumor, renal vein and renal artery benefits a lot on surgery-based renal cancer treatment. In this paper, we propose a new nnhra-unet network, and use a multi-stage framework which is based on ...
arxiv