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The emergence of ‘hypervirulence’ in Clostridium difficile
International Journal of Medical Microbiology, 2010 The impact of Clostridium difficile-associated disease (CDAD) in healthcare settings throughout the developed world is considerable in terms of mortality, morbidity, and disease management. The incidence of CDAD has risen dramatically since the turn of this century, concomitant with the emergence of so-called hypervirulent strains which are thought to ...
Stephen T Cartman +2 more
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Evolution of hypervirulence in Klebsiella [PDF]
Nature Reviews Microbiology, 2015 Naomi Attar, Attar Naomi
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Hypervirulent Klebsiella pneumoniae
New England Journal of Medicine, 2021Hypervirulent Klebsiella pneumoniae A 45-year-old man presented with eye pain and fever. Imaging showed multiple organ abscesses.
Qiong, Zou, Yang, Li
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Klebsiella species: Taxonomy, hypervirulence and multidrug resistance
EBioMedicine, 2022 Members of the genus Klebsiella have rapidly evolved within the past decade, generating organisms that simultaneously exhibit both multidrug resistance and hypervirulence (MDR-hv) phenotypes; such organisms are associated with severe hospital- and community-acquired infections.
Ning Dong +2 more
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Hypervirulence and pathogen fitness
Trends in Microbiology, 2003Historically, pathogenesis research has focused on the identification and characterization of virulence factors. More recently, 'anti-virulence' genes have been discovered. Mutations in these loci result in a hypervirulent phenotype, as measured by a lower lethal dose, a colonization advantage, reduced clearance or decreased survival time of the host ...
Amy K, Foreman-Wykert, Jeff F, Miller
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Hypervirulent Klebsiella pneumoniae detection methods: a minireview
Archives of Microbiology, 2023Hypervirulent Klebsiella pneumoniae (hvKp), characterized by high virulence and epidemic potential, has become a global public health challenge. Therefore, improving the identification of hvKp and enabling earlier and faster detection in the community to support subsequent effective treatment and prevention of hvKp are an urgent issue. To address these
Qi-Bin, Zhang +6 more
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Biodiversity and hypervirulence of Listeria monocytogenes
Nature Genetics, 2016The integration of large, well-sampled collections of bacterial isolates with genomics and experimental methods provides opportunities for 'top-down' discovery of the genetic basis of phenotypes of interest. In a new report, the authors apply this approach to investigate the heterogeneity in manifestations of disease caused by Listeria monocytogenes ...
Yonatan H Grad, Sarah M Fortune
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Hypervirulent Klebsiella Pneumoniae Osteomyelitis in a Child
Pediatric Infectious Disease JournalAn 18-month-old boy presented with septic arthritis and osteomyelitis caused by Hypervirulent Klebsiella pneumoniae harboring cardinal virulence genes. The condition necessitated several surgical interventions, and a prolonged course of antibiotic therapy to effectively manage the severe infection and prevent complications, highlighting the challenges ...
Ryoichi Yamaki +6 more
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Indian Journal of Medical Microbiology
An emerging pathotype of Klebsiella pneumoniae, initially identified in Southeast Asian countries, has now spread to multiple countries, including India. These convergent strains, carrying both resistance and virulence determinants, are classified as multidrug-resistant Hypervirulent Klebsiella pneumoniae (MDR-HvKp).
Sanika Mahesh Kulkarni +7 more
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An emerging pathotype of Klebsiella pneumoniae, initially identified in Southeast Asian countries, has now spread to multiple countries, including India. These convergent strains, carrying both resistance and virulence determinants, are classified as multidrug-resistant Hypervirulent Klebsiella pneumoniae (MDR-HvKp).
Sanika Mahesh Kulkarni +7 more
openaire +2 more sources