Results 61 to 70 of about 1,024 (191)

Photophysical Process of Hypocrellin-Based Photodynamic Therapy: An Efficient Antimicrobial Strategy for Overcoming Multidrug Resistance

Physics
The emergence of multidrug-resistant (MDR) bacteria and biofilm-associated infections has created a significant hurdle for conventional antibiotics, prompting the exploration of alternative strategies.
Pazhani Durgadevi, Koyeli Girigoswami, Agnishwar Girigoswami   +2 more
doaj   +1 more source

Effects of branched-chain amino acids on Shiraia perylenequinone production in mycelium cultures

Microbial Cell Factories, 2023
Background Perylenequinones from Shiraia fruiting bodies are excellent photosensitizers and widely used for anti-cancer photodynamic therapy (PDT). The lower yield of Shiraia perylenequinones becomes a significant bottleneck for their medical application.
Wen Hao Shen, Rui Peng Cong, Xin Ping Li, Qun Yan Huang, Li Ping Zheng, Jian Wen Wang   +5 more
doaj   +1 more source

Excited-State Intramolecular H Atom Transfer of Hypericin and Hypocrellin A Investigated by Fluorescence Upconversion [PDF]

, 1999
The excited-state intramolecular H atom transfer reaction occurring in hypericin and hypocrellin A is investigated by means of the fluorescence upconversion technique in a variety of solvents. Rising components of ∼10 ps, attributable to intramolecular H
Kraus, George, Smirnov, Andrei, Petrich, Jacob, English, D., Wan, Z., Das, K.   +5 more
core  

MOESM1 of Response mechanism of hypocrellin colorants biosynthesis by Shiraia bambusicola to elicitor PB90

, 2019
Additional file 1.
Jun Wang (5906), Jiangbao Xia (843443), Chunlong Sun (139693), Yanmei Wang (392327), Xuehong Liu (1267446), Baogui Wang (7384685), Wenjun Xie (482792), Wen Du (1857862), Jingkuan Sun (4683184), Bin Dong (147019), Hongguo Wang (7384688), Junhua Liu (1570747)   +11 more
core   +1 more source

The Combination of Active‐Targeted Photodynamic Therapy and Photoactivated Chemotherapy for Enhanced Cancer Treatment

Journal of Biophotonics, Volume 18, Issue 6, June 2025.
Photoactivated chemotherapy (PACT), an oxygen‐independent light‐based therapy, utilizes chemotherapeutic regimens that remain inert until exposed to light, allowing target‐specific activation while minimizing off‐target toxicity. The integration of these techniques has the potential to improve selectivity and yield synergistic cytotoxic effects that ...
Nkune Williams Nkune, Heidi Abrahamse
wiley   +1 more source

Hypocrellin A-based photodynamic action induces apoptosis in A549 cells through ROS-mediated mitochondrial signaling pathway

Acta Pharmaceutica Sinica B, 2019
Over recent decades, many studies have reported that hypocrellin A (HA) can eliminate cancer cells with proper irradiation in several cancer cell lines. However, the precise molecular mechanism underlying its anticancer effect has not been fully defined.
Shanshan Qi, Lingyuan Guo, Shuzhen Yan, Robert J. Lee, Shuqin Yu, Shuanglin Chen   +5 more
doaj   +1 more source

Hypericin, Hypocrellin, and Model Compounds:  Primary Photoprocesses of Light-Induced Antiviral Agents [PDF]

, 1997
The excited-state photophysics of the light-induced antiviral agents hypericin and hypocrellin are compared with those of the hexa- and tetramethoxy analogues of hypericin. The results are consistent with the interpretation of the primary photoprocess in
Kraus, George, Zenner, J., Petrich, Jacob, Larock, R., English, D., Das, K., Zhang, W.   +6 more
core  

Electrospun Nanofiber Platforms for Photodynamic Therapy: Role and Efficacy in Cancer, Antimicrobial, and Wound Healing Applications

Macromolecular Materials and Engineering, Volume 310, Issue 5, May 2025.
Electrospun nanofibers provide a unique platform for photosensitizers, due to their large surface area and biocompatibility, improving both loading efficiency and controlled release. The photosensitizer‐modified nanofibers are activated upon light exposure, and produce reactive oxygen species to treat cancer, pathogen infections, and wounds.
Aslı Eldem, Yamaç Tekintaş, Muhammed Ucuncu, Nesrin Horzum   +3 more
wiley   +1 more source

Design of Aromatic Interaction Networks in a Protein Cage Modulated by Fluorescent Ligand Binding

Advanced Science, Volume 12, Issue 15, April 17, 2025.
The study presents a novel system designed to control protein dynamics by orientational changes of aromatic residues triggered by ligand binding. By creating aromatic pockets within protein cages and binding fluorescent molecules via π–π interactions, the study achieves cooperative conformational change verified through X‐ray crystallography.
Yuki Hishikawa, Taiga Suzuki, Basudev Maity, Hiroki Noya, Michito Yoshizawa, Asuka Asanuma, Yuri Katagiri, Satoshi Abe, Satoru Nagatoishi, Kouhei Tsumoto, Takafumi Ueno   +10 more
wiley   +1 more source

Synergistic effect of hypocrellin B and curcumin on photodynamic inactivation of Staphylococcus aureus

Microbial Biotechnology, 2021
Summary Antimicrobial photodynamic inactivation (aPDI) serves as a new approach to control the growth of foodborne bacteria. It remains elusive if the photodynamic efficacy of hypocrellin B (HB) can be potentiated by joint action with curcumin.
Yali Li, Yi Xu, Qiaoming Liao, Mengmeng Xie, Han Tao, Hui‐Li Wang   +5 more
doaj   +1 more source