Phylogenetic Position of Shiraia-Like Endophytes on Bamboos and the Diverse Biosynthesis of Hypocrellin and Hypocrellin Derivatives [PDF]
Journal of Fungi, 2021 The main active ingredients of the fruiting bodies of Shiraia bambusicola and Rubroshiraia bambusae are Hypocrellins, belonging perylenequinones with potential photodynamic activity against cancer and microbial diseases.
Xin Tong +4 more
doaj +2 more sources
Antifungal activity of hypocrellin compounds and their synergistic effects with antimicrobial agents against Candida albicans [PDF]
Microbial Biotechnology, 2021 Summary Candida albicans is a common human fungal pathogen. The previous study revealed that quinone compounds showed antimicrobial activity against C. albicans by inhibiting cell growth.
Shihao Song +5 more
doaj +2 more sources
Volatiles of Shiraia fruiting body-associated Pseudomonas putida No.24 stimulate fungal hypocrellin production [PDF]
Synthetic and Systems Biotechnology, 2023 Hypocrellins are major bioactive perylenequinones from Shiraia fruiting bodies and have been developed as efficient photosensitizers for photodynamic therapy.
Rui Xu +5 more
doaj +2 more sources
Production of fungal hypocrellin photosensitizers: Exploiting bambusicolous fungi and elicitation strategies in mycelium cultures [PDF]
MycologyHypocrellins, a group of naturally occurring perylenequinone pigments produced by Shiraia bambusicola, are notable for their potential use in photodynamic therapy (PDT) for treating cancers and viruses.
Xin Ping Li +3 more
doaj +2 more sources
Rapid Degradation of Rhodamine B through Visible-Photocatalytic Advanced Oxidation Using Self-Degradable Natural Perylene Quinone Derivatives—Hypocrellins [PDF]
Bioengineering, 2022 Hypocrellins (HYPs) are natural perylene quinone derivatives from Ascomycota fungi. Based on the excellent photosensitization properties of HYPs, this work proposed a photocatalytic advanced oxidation process (PAOP) that uses HYPs to degrade rhodamine B (
Zhixian Huang +6 more
doaj +2 more sources
Nitric oxide donor sodium nitroprusside-induced transcriptional changes and hypocrellin biosynthesis of Shiraia sp. S9 [PDF]
Microbial Cell Factories, 2021 Background Nitric oxide (NO) is a ubiquitous signaling mediator in various physiological processes. However, there are less reports concerning the effects of NO on fungal secondary metabolites.
Yan Jun Ma +3 more
doaj +2 more sources
Optimisation of hypocrellin production in Shiraia-like fungi via genetic modification involving a transcription factor gene and a putative monooxygenase gene [PDF]
MycologyShiraia-like fungi, which are rare parasitic fungi found around bamboo, play an important role in traditional medicine. Their main active component, hypocrellin, is widely used in medicine, food, and cosmetics.
Zi-Min Lu +6 more
doaj +2 more sources
Enhancement of Perylenequinonoid Compounds Production from Strain of Pseudoshiraia conidialis by UV-Induced Mutagenesis [PDF]
MicroorganismsPerylenequinonoid compounds, represented by photosensitive therapeutic agents such as hypocrellins and elsinochromes, demonstrate extensive potential across biomedical, agricultural, and food industrial applications.
Xin Tong +3 more
doaj +2 more sources
Scaling up the production of fungal perylenequinones and investigating their biosynthesis through stable isotope labeling [PDF]
Microbial Cell FactoriesBackground Perylenequinones, such as hypocrellins and hypomycins, are fungal secondary metabolites with potential for pharmaceutical and industrial applications due to both their physical and biological properties. This study focused on their sustainable
Reema A. Al-Qiam +7 more
doaj +2 more sources
Effects of branched-chain amino acids on Shiraia perylenequinone production in mycelium cultures [PDF]
Microbial Cell Factories, 2023 Background Perylenequinones from Shiraia fruiting bodies are excellent photosensitizers and widely used for anti-cancer photodynamic therapy (PDT). The lower yield of Shiraia perylenequinones becomes a significant bottleneck for their medical application.
Wen Hao Shen +5 more
doaj +2 more sources