Results 171 to 180 of about 29,698,539 (199)

Undetectable CSF hypocretin-1 in “Hashimoto’s encephalopathy” associated with coma

Neurology, 2004
Hypersomnolence has been reported in 40% of patients with steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT),1,2⇓ sometimes termed “Hashimoto’s encephalopathy.”3,4⇓ We present a patient with SREAT and hypersomnolence and then coma who while symptomatic had undetectable levels of hypocretin-1 in the CSF.
Pablo R, Castillo, Emmanuel, Mignot, Bryan K, Woodruff, Bradley F, Boeve   +3 more
openaire   +2 more sources

Low CSF hypocretin-1 levels in an adult patient with hypothalamic hamartoma

Neurology, 2020
Patients with hypothalamic hamartomas (HHs) located at the level of the mammillary bodies may present with a peculiar epileptic syndrome characterized by gelastic seizures and, commonly, falls.1–4 Associated symptoms can include developmental delay, cognitive deterioration, psychiatric disorders, central precocious puberty, and sleep disturbances.1,4–6
Muccioli, L, Bisulli, F, Licchetta, L, Pizza, F, Moresco, M, Martinoni, M, Zucchelli, M, Plazzi, G, Tinuper, P   +8 more
openaire   +3 more sources

Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients

Neurology, 2001
Deficient orexin signaling has been shown to cause narcolepsy-like conditions in animals. In human narcolepsy, CSF levels of orexin A (hypocretin-1) were reported to be low in most cases. The authors measured CSF and plasma orexin A levels in patients with narcolepsy and in controls.
Dalal, M., Schuld, A., Haack, M., Uhr, M., Geisler, P., Eisensehr, I., Noachtar, S., Pollmächer, T.   +7 more
openaire   +3 more sources

Cerebrospinal fluid hypocretin‐1 levels in multiple system atrophy

Movement Disorders, 2007
AbstractHypocretin (orexin) cerebrospinal fluid (CSF) levels have been previously found normal or decreased in Dementia with Lewy bodies and Parkinson disease, two synucleinopathies commonly associated with excessive daytime sleepiness (EDS). We evaluated CSF hypocretin‐1 levels in 15 patients with moderately severe multiple system atrophy (MSA ...
Jose Enrique, Martinez-Rodriguez, Klaus, Seppi, Adriana, Cardozo, Alex, Iranzo, Michaela, Stampfer-Kountchev, Gregor, Wenning, Eduardo, Tolosa, Birgit, Högl, Joan, Santamaria, Werner, Poewe   +9 more
openaire   +2 more sources

Normalization of hypocretin-1 in narcolepsy after intravenous immunoglobulin treatment

Neurology, 2009
In May 2006, a 28-year-old woman abruptly experienced excessive daytime sleepiness (EDS) and 2 to 3 short, refreshing but irresistible naps per day. She also reported increased nighttime sleep duration of more than 3 hours. Her Epworth Sleepiness Scale score was 22, indicating severe sleepiness.
Y, Dauvilliers, B, Abril, E, Mas, F, Michel, M, Tafti   +4 more
openaire   +2 more sources

CSF hypocretin-1 levels in schizophrenics and controls: relationship to sleep architecture

Psychiatry Research, 2002
Hypocretins/orexins are newly identified peptides of hypothalamic origin. Hypocretin deficiency is involved in the sleep disorder narcolepsy, suggesting the importance of hypocretin neurotransmission for the regulation of sleep. Hypocretin is known to excite midbrain dopaminergic neurons and to induce hyperactivity and stereotypy in animals.
Seiji, Nishino, Beth, Ripley, Emmanuel, Mignot, Kathleen L, Benson, Vincent P, Zarcone   +4 more
openaire   +2 more sources

Functional opioid pathways are necessary for hypocretin-1 (orexin-A)-induced feeding

Peptides, 2004
We investigated the interaction of the orexigenic neuropeptide, hypocretin-1 (Hcrt-1, also known as orexin-A), with endogenous opioids (also orexigenic neuropeptides). Rats were injected with naltrexone (NTX, nonspecific opioid antagonist) i.p., i.c.v., in the lateral hypothalamus (LH), and in the accumbens shell (AcbSh), and naloxone methiodide ...
Donald C, Sweet, Allen S, Levine, Catherine M, Kotz   +2 more
openaire   +2 more sources

CSF hypocretin-1 (orexin-A) levels in childhood narcolepsy and neurologic disorders

Neurology, 2004
Hypersomnia and cataplexy expression in childhood narcolepsy are often different from adult cases, making diagnosis difficult.1 The Multiple Sleep Latency Test (MSLT) for demonstrating hypersomnia and sleep-onset REM periods has not been standardized for children under age 82 and has limited value in pediatrics.
J, Arii, T, Kanbayashi, Y, Tanabe, Y, Sawaishi, S, Kimura, A, Watanabe, K, Mishima, Y, Hishikawa, T, Shimizu, S, Nishino   +9 more
openaire   +2 more sources

CSF orexin-A/hypocretin-1 concentrations in patients with intracerebral hemorrhage (ICH)

Regulatory Peptides, 2008
Orexins/hypocretins are neuropeptides that have various physiological effects, including the regulation of both the feeding behavior neuroendocrine functions and sleep-wakefulness cycle. Recent studies have suggested that the orexin system may also be involved in neuronal damage in the clinical setting and animal experiments.
Kenji, Dohi, Beth, Ripley, Nobuhiro, Fujiki, Hirokazu, Ohtaki, Takefumi, Yamamoto, Yoko, Goto, Tomoya, Nakamachi, Seiji, Shioda, Tohru, Aruga, Seiji, Nishino   +9 more
openaire   +2 more sources

CSF hypocretin-1/orexin-A concentrations in patients with subarachnoid hemorrhage (SAH)

Peptides, 2005
The aim of this study was to examine the role of the hypothalamic hypocretin/orexin system in complications of delayed ischemic neuronal deficit (DIND) resulting from symptomatic vasospasm in patients with aneurysmal subarachnoid hemorrhage (SAH). CSF hypocretin-1/orexin-A levels were measured in 15 SAH patients.
K, Dohi, B, Ripley, N, Fujiki, H, Ohtaki, S, Shioda, T, Aruga, S, Nishino   +6 more
openaire   +2 more sources