Results 151 to 160 of about 29,698,539 (199)
Hypocretin (orexin) loss in Parkinson's disease [PDF]
Brain, 2007 The hypothalamic hypocretin (orexin) system plays a central role in the regulation of various functions, including sleep/wake regulation and metabolism.
Rolf Fronczek +2 more
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Hypocretin (orexin) loss in Alzheimer's disease [PDF]
Neurobiology of Aging, 2012 Contains fulltext : 108183.pdf (Publisher’s version ) (Closed access)Sleep disturbances in Alzheimer's disease (AD) patients are associated with the severity of dementia and are often the primary reason for institutionalization.
Rolf Fronczek +2 more
exaly +2 more sources
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Hypocretin-1 Deficiency in a Girl With ROHHAD Syndrome
Pediatrics, 2013Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare and complex pediatric syndrome, essentially caused by dysfunction of 3 vital systems regulating endocrine, respiratory, and autonomic nervous system functioning.
Dhondt, K. +4 more
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Hypocretin-1 and secondary signs in Huntington's disease
Parkinsonism & Related Disorders, 2007Huntington's disease is characterised by unwanted movements, psychiatric disturbances and cognitive decline. Less well recognised symptoms and signs are weight loss, autonomic dysfunction and sleep disorders. In this study we focus on hypocretin-1 and hypothalamus functions. We found a reduction by about 30% in hypocretin signalling in patients with HD.
R A C, Roos, N A, Aziz
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Cardiac effects of hypocretin-1 in nucleus ambiguus
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2003Although recent studies have reported hypocretin 1 (hcrt-1)-like-immunoreactivity (ir) within the region of the nucleus ambiguus (Amb) in the caudal brain stem, the function of hcrt-1 in the Amb on cardiovascular function is not known. Three series of experiments were done in male Wistar rats to investigate the effects of microinjections of hcrt-1 ...
John, Ciriello, Cleusa V R, de Oliveira
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Hypocretin-1 levels in Angelman syndrome
Sleep and Biological Rhythms, 2006Angelman syndrome (AS) and Prader-Willi syndrome (PWS) are neurodevelopmental disorders caused by deletion or mutation within maternal or paternal chromosome 15q11–q13, respectively. Patients with AS are poor sleepers and patients with PWS often exhibit excessive daytime sleepiness. Because of reports of low CSF hypocretin-1 levels in PWS patients with
Rie MIYATA +4 more
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Hypocretin/orexin disturbances in neurological disorders [PDF]
Sleep Medicine Reviews, 2009 The hypothalamic hypocretin (orexin) system plays a crucial role in the regulation of sleep and wakefulness. The strongest evidence for this is the fact that the primary sleep disorder narcolepsy is caused by disrupted hypocretin signaling in humans as ...
Rolf Fronczek +2 more
exaly +2 more sources
CSF hypocretin-1 assessment in sleep and neurological disorders
The Lancet Neurology, 2008Concentrations of CSF hypocretin-1 (formerly orexin A) have been measured in many patients with sleep or neurological conditions. Low CSF hypocretin-1 is most predictive of narcolepsy in patients positive for HLA allele DQB1*0602, most of whom have cataplexy. By contrast, the diagnostic significance of low CSF hypocretin-1 is unclear in the presence of
Patrice, Bourgin +2 more
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Predictors of Hypocretin (Orexin) Deficiency in Narcolepsy Without Cataplexy
Sleep, 2012 Study Objectives: To compare clinical, electrophysiologic, and biologic data in narcolepsy without cataplexy with low (<= 110 pg/ml), intermediate (110-200 pg/ml), and normal (> 200 pg/ml) concentrations of cerebrospinal fluid (CSF) hypocretin-1.
Poul Jennum +2 more
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Convergence of circadian and sleep regulatory mechanisms on hypocretin-1
Neuroscience, 2004Hypocretin is a potential regulator of sleep and wakefulness and its levels fluctuate with the day-night cycle with high levels during the animal's activity period. Whether the daily fluctuations are driven endogenously or by external light cycles is unknown.
T, Deboer +6 more
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