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Treatment of Narcolepsy Type 1 With Orexin: A Systematic Review. [PDF]
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Orexin (hypocretin) and addiction
Trends in Neurosciences, 2021Although originally implicated in appetite and sleep/wakefulness, the hypothalamic orexin (hypocretin) system has now been demonstrably linked with motivated behavior. This highly plastic system responds to reward-associated environmental stimuli and becomes pathologically overactive in addicted states. Here, we provide a brief overview of the roles of
Jacqueline B. Mehr +2 more
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Relationship between CSF hypocretin levels and hypocretin neuronal loss
Experimental Neurology, 2003The sleep disorder narcolepsy may now be considered a neurodegenerative disease, as there is a massive reduction in the number of neurons containing the neuropeptide, hypocretin (HCRT). Most narcoleptic patients have low to negligible levels of HCRT in the cerebrospinal fluid (CSF), and such measurements serve as an important diagnostic tool.
Dmitry, Gerashchenko +7 more
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Narcolepsy and the hypocretins
Metabolism, 2006Narcolepsy is a chronic neurologic disease characterized by excessive daytime sleepiness and one or more of three additional symptoms (cataplexy, or sudden loss of muscle tone; vivid hallucinations; and brief periods of total paralysis) related to the occurrence of rapid eye movement (REM) sleep at inappropriate times.
M, Hungs, E, Mignot
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Trends in Endocrinology & Metabolism, 2000
Newly described peptides, produced in neurons in the lateral hypothalamic area, have been shown to stimulate appetite and stereotypic behaviors associated with feeding. Discovered independently by two groups, the hypocretins/orexins stimulate autonomic function and have been shown to be physiological regulators of the arousal state.
W K, Samson, Z T, Resch
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Newly described peptides, produced in neurons in the lateral hypothalamic area, have been shown to stimulate appetite and stereotypic behaviors associated with feeding. Discovered independently by two groups, the hypocretins/orexins stimulate autonomic function and have been shown to be physiological regulators of the arousal state.
W K, Samson, Z T, Resch
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Orexins (Hypocretins) and Adrenal Function
Hormone and Metabolic Research, 2004The recently discovered neuropeptides orexin A and B regulate feeding behavior, neuroendocrine and autonomic functions, and sleep-wakefulness by central mechanisms. The expression of orexins and orexin receptors in various peripheral organs and the presence of orexin A in blood indicate the existence of a peripheral orexin system.
O, Jöhren, N, Brüggemann, P, Dominiak
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Orexins/hypocretins and aminergic systems
Acta Physiologica, 2010AbstractOrexin/hypocretin neurones in the posterior hypothalamus are mutually connected with noradrenergic, serotonergic, dopaminergic, histaminergic, and cholinergic neurone systems. They activate these targets by direct post‐synaptic and indirect pre‐synaptic mechanisms and in turn receive inhibitory feedback and excitatory feed forward control. With
K S, Eriksson +3 more
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Hypocretin/orexin and energy expenditure
Acta Physiologica, 2010AbstractThe hypocretins or orexins are endogenous neuropeptides synthesized in discrete lateral, perifornical and dorsal hypothalamic neurones. These multi‐functional neuropeptides modulate energy homeostasis, arousal, stress, reward, reproduction and cardiovascular function.
J A, Teske, C J, Billington, C M, Kotz
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2015
The main topic of this book stems from the discovery of two neuropeptides derived from the same precursor, conducted in parallel by two different groups (de Lecea et al. in Proc Natl Acad Sci USA 95:322–327, 1998; Sakurai et al. in Cell 92:573–585, 1998).
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The main topic of this book stems from the discovery of two neuropeptides derived from the same precursor, conducted in parallel by two different groups (de Lecea et al. in Proc Natl Acad Sci USA 95:322–327, 1998; Sakurai et al. in Cell 92:573–585, 1998).
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