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Hypocretin (orexin) loss in Alzheimer's disease [PDF]
Neurobiology of Aging, 2012 Contains fulltext : 108183.pdf (Publisher’s version ) (Closed access)Sleep disturbances in Alzheimer's disease (AD) patients are associated with the severity of dementia and are often the primary reason for institutionalization.
Rolf Fronczek +2 more
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Hypocretin/orexin disturbances in neurological disorders [PDF]
Sleep Medicine Reviews, 2009 The hypothalamic hypocretin (orexin) system plays a crucial role in the regulation of sleep and wakefulness. The strongest evidence for this is the fact that the primary sleep disorder narcolepsy is caused by disrupted hypocretin signaling in humans as ...
Rolf Fronczek +2 more
exaly +2 more sources
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The hypocretin (orexin) system: from a neural circuitry perspective.
Neuropharmacology, 2020Hypocretin/orexin neurons are distributed restrictively in the hypothalamus, a brain region known to orchestrate diverse functions including sleep, reward processing, food intake, thermogenesis, and mood.
Shi-bin Li, L. de Lecea
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Linking peripheral IL-6, IL-1β and hypocretin-1 with cognitive impairment from major depression.
Journal of Affective Disorders, 2020BACKGROUND Cognitive impairment has long challenged the patients with major depressive disorder (MDD), hypocretins and inflammation have recently been implicated in cognitive function.
Kang-Yu Jin +7 more
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The orexin/hypocretin system in neuropsychiatric disorders: Relation to signs and symptoms.
Handbook of Clinical Neurology, 2021Hypocretin-1 and 2 (or orexin A and B) are neuropeptides exclusively produced by a group of neurons in the lateral and dorsomedial hypothalamus that project throughout the brain.
R. Fronczek +3 more
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Biomedicines
The orexin/hypocretin neuropeptide family has emerged as a focal point of neuroscientific research following the discovery that this family plays a crucial role in a variety of physiological and behavioral processes. These neuropeptides serve as powerful
M. Jászberényi +4 more
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The orexin/hypocretin neuropeptide family has emerged as a focal point of neuroscientific research following the discovery that this family plays a crucial role in a variety of physiological and behavioral processes. These neuropeptides serve as powerful
M. Jászberényi +4 more
semanticscholar +1 more source
Narcolepsy and the hypocretins
Metabolism, 2006Narcolepsy is a chronic neurologic disease characterized by excessive daytime sleepiness and one or more of three additional symptoms (cataplexy, or sudden loss of muscle tone; vivid hallucinations; and brief periods of total paralysis) related to the occurrence of rapid eye movement (REM) sleep at inappropriate times.
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Brain Research, 2020
Since its discovery in 1998, the hypocretin/orexin system has been identified as a critical modulator of behavior. Through interactions with dopamine neurons of the ventral tegmental area, this system is poised to regulate motivation for drug rewards by ...
Zachary D. Brodnik +5 more
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Since its discovery in 1998, the hypocretin/orexin system has been identified as a critical modulator of behavior. Through interactions with dopamine neurons of the ventral tegmental area, this system is poised to regulate motivation for drug rewards by ...
Zachary D. Brodnik +5 more
semanticscholar +1 more source
Relationship between CSF hypocretin levels and hypocretin neuronal loss
Experimental Neurology, 2003The sleep disorder narcolepsy may now be considered a neurodegenerative disease, as there is a massive reduction in the number of neurons containing the neuropeptide, hypocretin (HCRT). Most narcoleptic patients have low to negligible levels of HCRT in the cerebrospinal fluid (CSF), and such measurements serve as an important diagnostic tool.
Priyattam Shiromani +2 more
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Trends in Endocrinology & Metabolism, 2000
Newly described peptides, produced in neurons in the lateral hypothalamic area, have been shown to stimulate appetite and stereotypic behaviors associated with feeding. Discovered independently by two groups, the hypocretins/orexins stimulate autonomic function and have been shown to be physiological regulators of the arousal state.
W K, Samson, Z T, Resch
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Newly described peptides, produced in neurons in the lateral hypothalamic area, have been shown to stimulate appetite and stereotypic behaviors associated with feeding. Discovered independently by two groups, the hypocretins/orexins stimulate autonomic function and have been shown to be physiological regulators of the arousal state.
W K, Samson, Z T, Resch
openaire +2 more sources