Results 191 to 200 of about 8,767 (247)
T cells in patients with narcolepsy target self-antigens of hypocretin neurons
Nature, 2018 Narcolepsy is a chronic sleep disorder caused by the loss of neurons that produce hypocretin. The close association with HLA-DQB1*06:02, evidence for immune dysregulation and increased incidence upon influenza vaccination together suggest that this ...
Daniela Latorre +2 more
exaly +3 more sources
Orexin (hypocretin) and addiction
Trends in Neurosciences, 2021 Although originally implicated in appetite and sleep/wakefulness, the hypothalamic orexin (hypocretin) system has now been demonstrably linked with motivated behavior. This highly plastic system responds to reward-associated environmental stimuli and becomes pathologically overactive in addicted states. Here, we provide a brief overview of the roles of
Jacqueline B. Mehr +2 more
openaire +3 more sources
Hypocretin (orexin) loss in Parkinson's disease
Brain, 2007 The hypothalamic hypocretin (orexin) system plays a central role in the regulation of various functions, including sleep/wake regulation and metabolism.
Rolf Fronczek +2 more
exaly +2 more sources
Hypocretin/orexin disturbances in neurological disorders
Sleep Medicine Reviews, 2009 The hypothalamic hypocretin (orexin) system plays a crucial role in the regulation of sleep and wakefulness. The strongest evidence for this is the fact that the primary sleep disorder narcolepsy is caused by disrupted hypocretin signaling in humans as ...
Rolf Fronczek +2 more
exaly +2 more sources
Changes of Hypocretin (Orexin) System in Schizophrenia: From Plasma to Brain
Schizophrenia Bulletin, 2021 Hypocretin (also called orexin) regulates various functions, such as sleep-wake rhythms, attention, cognition, and energy balance, which show significant changes in schizophrenia (SCZ).
Jing Lu, Rolf Fronczek, Dick F Swaab
exaly +2 more sources
Hypocretin (orexin) loss in Alzheimer's disease
Neurobiology of Aging, 2012 Contains fulltext : 108183.pdf (Publisher’s version ) (Closed access)Sleep disturbances in Alzheimer's disease (AD) patients are associated with the severity of dementia and are often the primary reason for institutionalization.
Rolf Fronczek +2 more
exaly +2 more sources
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Hypocretin (orexin) deficiency in human narcolepsy
Lancet, The, 2000Seiji Nishino +2 more
exaly +2 more sources
The hypocretin (orexin) system: from a neural circuitry perspective.
Neuropharmacology, 2020Hypocretin/orexin neurons are distributed restrictively in the hypothalamus, a brain region known to orchestrate diverse functions including sleep, reward processing, food intake, thermogenesis, and mood.
Shi-bin Li, L. de Lecea
semanticscholar +1 more source