Results 201 to 210 of about 8,767 (247)
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Linking peripheral IL-6, IL-1β and hypocretin-1 with cognitive impairment from major depression.
Journal of Affective Disorders, 2020BACKGROUND Cognitive impairment has long challenged the patients with major depressive disorder (MDD), hypocretins and inflammation have recently been implicated in cognitive function.
K. Jin +7 more
semanticscholar +1 more source
Cell Metabolism, 2018 SUMMARY We investigated relationships among immune, metabolic, and sleep abnormalities in mice with non-metastatic mammary cancer. Tumor-bearing mice displayed IL-6 mediated peripheral inflammation, coincident with altered hepatic glucose processing and ...
Jeremy C Borniger +2 more
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The orexin/hypocretin system in neuropsychiatric disorders: Relation to signs and symptoms.
Handbook of Clinical Neurology, 2021Hypocretin-1 and 2 (or orexin A and B) are neuropeptides exclusively produced by a group of neurons in the lateral and dorsomedial hypothalamus that project throughout the brain.
R. Fronczek +3 more
semanticscholar +1 more source
Journal of Cellular and Molecular Medicine, 2019 Hypocretin 1 and hypocretin 2 (orexin A and B) regulate sleep, wakefulness and emotion. Tumour necrosis factor alpha (TNF‐α) is an important neuroinflammation mediator. Here, we examined the effects of TNF‐α treatment on hypocretin expression in vivo and
Shuqin Zhan, Pulin Che, Xue-Ke Zhao
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Predictors of Hypocretin (Orexin) Deficiency in Narcolepsy Without Cataplexy
Sleep, 2012 Study Objectives: To compare clinical, electrophysiologic, and biologic data in narcolepsy without cataplexy with low (<= 110 pg/ml), intermediate (110-200 pg/ml), and normal (> 200 pg/ml) concentrations of cerebrospinal fluid (CSF) hypocretin-1.
Olivier Andlauer +2 more
exaly +2 more sources
Narcolepsy and the hypocretins
Metabolism, 2006Narcolepsy is a chronic neurologic disease characterized by excessive daytime sleepiness and one or more of three additional symptoms (cataplexy, or sudden loss of muscle tone; vivid hallucinations; and brief periods of total paralysis) related to the occurrence of rapid eye movement (REM) sleep at inappropriate times.
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Brain Research, 2020
Since its discovery in 1998, the hypocretin/orexin system has been identified as a critical modulator of behavior. Through interactions with dopamine neurons of the ventral tegmental area, this system is poised to regulate motivation for drug rewards by ...
Zachary D. Brodnik +5 more
semanticscholar +1 more source
Since its discovery in 1998, the hypocretin/orexin system has been identified as a critical modulator of behavior. Through interactions with dopamine neurons of the ventral tegmental area, this system is poised to regulate motivation for drug rewards by ...
Zachary D. Brodnik +5 more
semanticscholar +1 more source
The Hypocretins and their Role in Narcolepsy
CNS & Neurological Disorders - Drug Targets, 2009A series of discoveries spanning the last decade have uncovered a new neurotransmitter - hypocretin - and its role in energy metabolism, arousal, and addiction. Also, notably, a lack of hypocretin function has been unequivocally associated with the sleep disorder narcolepsy.
Daniel, Kroeger, Luis, de Lecea
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Trends in Endocrinology & Metabolism, 2000
Newly described peptides, produced in neurons in the lateral hypothalamic area, have been shown to stimulate appetite and stereotypic behaviors associated with feeding. Discovered independently by two groups, the hypocretins/orexins stimulate autonomic function and have been shown to be physiological regulators of the arousal state.
W K, Samson, Z T, Resch
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Newly described peptides, produced in neurons in the lateral hypothalamic area, have been shown to stimulate appetite and stereotypic behaviors associated with feeding. Discovered independently by two groups, the hypocretins/orexins stimulate autonomic function and have been shown to be physiological regulators of the arousal state.
W K, Samson, Z T, Resch
openaire +2 more sources
Relationship between CSF hypocretin levels and hypocretin neuronal loss
Experimental Neurology, 2003The sleep disorder narcolepsy may now be considered a neurodegenerative disease, as there is a massive reduction in the number of neurons containing the neuropeptide, hypocretin (HCRT). Most narcoleptic patients have low to negligible levels of HCRT in the cerebrospinal fluid (CSF), and such measurements serve as an important diagnostic tool.
Dmitry, Gerashchenko +7 more
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